Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDKL5_HUMAN
Description:cyclin-dependent kinase-like 5 [Source:HGNC Symbol;Acc:11411]
Location:chrX p22.13
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y188LLGAPyGKSVDPkinasePhosphoSitePlus
Y171ANYTEyVATRWPkinasePhosphoSitePlus
S646SLQLLsPQPGEPhosphoSitePlus; HPRD
Y171ANYTEyVATRWHPRD
S833DLQTQsQPLKSPhosphoSitePlus
T528DLNSPtSPTPTHPRD
T813IHSAStPSSRPPhosphoSitePlus
T831ISDLQtQSQPLPhosphoSitePlus
Y686SEGGVyHDPHSPhosphoSitePlus
Y262SLERRyLGILNPkinasePhosphoSitePlus
T983LQVRGtDAFSCPhosphoSitePlus
S343HHRSNsKDIQNPhosphoSitePlus
S407IPHLLsPKEAKPhosphoSitePlus; HPRD; phosphoELM
S681HTRQKsEGGVYHPRD
S512QIAEPsTSRYFPhosphoSitePlus; HPRD
S375NLAGAsLSPLHHPRD
S529LNSPTsPTPTRPhosphoSitePlus
S446QQNRHsFMESSPhosphoSitePlus
S543TRTLLsPSGRNHPRD
S306RLLDRsPSRSAPhosphoSitePlus; HPRD
S520RYFPSsCLDLNPhosphoSitePlus
S377AGASLsPLHTKPhosphoSitePlus; HPRD
Y704ENRHLyNDPVPPhosphoSitePlus
Y286DPADRyLTEQCPkinasePhosphoSitePlus
T169NNANYtEYVATPkinasePhosphoSitePlus
T533TSPTPtRHSDTPhosphoSitePlus
S341QSHHRsNSKDIPhosphoSitePlus
Y168GNNANyTEYVAPkinasePhosphoSitePlus
S476DTIPQsSRSPSHPRD
S488RTKAKsHGALSPhosphoSitePlus
S761FDPWKsPENISPhosphoSitePlus; HPRD
Y177VATRWyRSPELPkinasePhosphoSitePlus
S726PRPDNsFHENNPhosphoSitePlus; HPRD
S987GTDAFsCPTQQPhosphoSitePlus
Y482SRSPSyRTKAKPhosphoSitePlus
S526CLDLNsPTSPTPhosphoSitePlus; HPRD
S720FYRVPsPRPDNPhosphoSitePlus; HPRD

Dephosphorylation site
CDKL5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369325Y433FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000369332A374TGreenman2007Skin Cancer17344846, 18428421
ENSP00000369325P574QGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000369325D905DTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369325A374TGreenman2007Skin Cancer17344846, 18428421
ENSP00000369332P574QGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000369332N368HSjoblom2006Intestines Cancer16959974
ENSP00000369332N368HHPIColorectal Cancer16959974
ENSP00000369325N368HBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000369332D905DTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369325N368HSjoblom2006Intestines Cancer16959974, 21930507, 21930502

Differential expressed protein
CDKL5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDKL5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDKL5_HUMANCIAO1_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANPLCD4_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANZBED1_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANSRA1_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANDGCR8_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANSSBP4_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANACL6B_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANZN238_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANPBX2_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANRAD51_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANPTBP1_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANGPBL1_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANNOC4L_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANCSTFT_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANDX39A_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANNOL7_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
CDKL5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045773positive regulation of axon extensionISSbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0050775positive regulation of dendrite morphogenesisISSbiological_process
GO:0032839dendrite cytoplasmISScellular_component
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:0050773regulation of dendrite developmentISSbiological_process
GO:0032587ruffle membraneISScellular_component
GO:0044294dendritic growth coneISScellular_component
GO:0048365Rac GTPase bindingISSmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0016301kinase activityIDAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0032855positive regulation of Rac GTPase activityISSbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0001764neuron migrationISSbiological_process
GO:0004672protein kinase activityIDAmolecular_function


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