Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WWTR1_HUMAN
Description:WW domain containing transcription regulator 1 [Source:HGNC Symbol;Acc:24042]
Location:chr3 q25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S117HLRQQsYDVTDPhosphoSitePlus; HPRD
S58FKEPDsGSHSRPhosphoSitePlus
S105AGAAGsPAQQHPhosphoSitePlus; HPRD; phosphoELM
T67SRQSStDSSGGPhosphoSitePlus
T98SLQLGtGAGAAHPRD; phosphoELM
S93HSSPAsLQLGTPhosphoSitePlus; HPRD; phosphoELM
S66HSRQSsTDSSGPhosphoSitePlus
S307GGPYHsREQSTPhosphoSitePlus
S87AQHVRsHSSPAPhosphoSitePlus; HPRD; phosphoELM
S89HVRSHsSPASLPhosphoSitePlus; HPRD
S60EPDSGsHSRQSPhosphoSitePlus
S69QSSTDsSGGHPPhosphoSitePlus
S62DSGSHsRQSSTPhosphoSitePlus
T312SREQStDSGLGPhosphoSitePlus
S393SALNKsEPFLTPhosphoSitePlus; HPRD
S65SHSRQsSTDSSPhosphoSitePlus
S70SSTDSsGGHPGPhosphoSitePlus
S90VRSHSsPASLQPhosphoSitePlus; HPRD
S311HSREQsTDSGLPhosphoSitePlus
S314EQSTDsGLGLGPhosphoSitePlus
Y118LRQQSyDVTDEHPRD

Dephosphorylation site
WWTR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353847Q353*COSMICMelanoma21499247
ENSP00000353847F299VCOSMICBreast Cancer20393555

Differential expressed protein
WWTR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WWTR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BTK_HUMANWWTR1_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANWWTR1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANWWTR1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANWWTR1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
WWTR1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0035329hippo signaling cascadeIDAbiological_process
GO:0032835glomerulus developmentIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0001933negative regulation of protein phosphorylationIMPbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0010718positive regulation of epithelial to mesenchymal tIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045599negative regulation of fat cell differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0060271cilium morphogenesisIEAbiological_process
GO:0003713transcription coactivator activityIEAmolecular_function
GO:0035414negative regulation of catenin import into nucleusIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0017145stem cell divisionIDAbiological_process
GO:0060390regulation of SMAD protein import into nucleusIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0006469negative regulation of protein kinase activityIMPbiological_process


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