Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LIMK2_HUMAN
Description:LIM domain kinase 2 [Source:HGNC Symbol;Acc:6614]
Location:chr22 q12.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T505RKKRYtVVGNPROCK_groupphosphoELM; RegPhos
T526KSYDEtVDIFSCDC42BPAHPRD
S166GRRGFsVSVESThioredoxin; PDZPhosphoSitePlus
T151LPYSVtLISMPThioredoxinPhosphoSitePlus
T179SNYATtVQVKEThioredoxin; PDZPhosphoSitePlus
S168RGFSVsVESACThioredoxin; PDZPhosphoSitePlus
S191NRMHIsPNNRNHPRD; SysPTM
S277SPGPSsPKEPLHPRD
T526KSYDEtVDIFSROCK1HPRD; RegPhos
T505RKKRYtVVGNPMRCKaphosphoELM; RegPhos
T505RKKRYtVVGNPPkinase_TyrPhosphoSitePlus
T505RKKRYtVVGNPphosphoELM; RegPhos
T210LEINGtPVRTLHPRD; SysPTM
S297KSPGPsSPKEPPhosphoSitePlus; HPRD
S293NSISKsPGPSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S170NRMHIsPNNRNHPRD
S287RSLRRsNSISKPhosphoSitePlus; HPRD; phosphoELM
S149EQLPYsVTLISThioredoxinPhosphoSitePlus
T505KSYDEtVDIFSCDC42BPAHPRD
T505KSYDEtVDIFSROCK1HPRD
S298SPGPSsPKEPLPhosphoSitePlus; HPRD; phosphoELM
S289LRRSNsISKSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S318ESLRCsSSYSQPhosphoSitePlus
T210LEINGtPVRTLPDZPhosphoSitePlus; SysPTM
S276KSPGPsSPKEPHPRD
S291RSNSIsKSPGPPhosphoSitePlus; phosphoELM; RegPhos
T278ENLEGtLRRRSPhosphoSitePlus
S283TLRRRsLRRSNPKC_deltaphosphoELM
S283TLRRRsLRRSNPhosphoSitePlus
S283TLRRRsLRRSNPKCd(PKC deltaRegPhos
T189LEINGtPVRTLHPRD
T505RKKRYtVVGNPROCK1RegPhos
T494TTKKRtLRKNDPkinase_TyrPhosphoSitePlus
S266RSLRRsNSISKHPRD
S268LRRSNsISKSPHPRD
S272NSISKsPGPSSHPRD
T526KSYDEtVDIFSMRCKaRegPhos
S191NRMHIsPNNRNPDZPhosphoSitePlus; SysPTM

Dephosphorylation site
LIMK2_HUMAN do not have dephosphorylation site.

Mutation site
LIMK2_HUMAN do not have mutation site.

Differential expressed protein
LIMK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LIMK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LIMK2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
LIMK2_HUMANDD19B_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANLIMK2_HUMANkinase -> substrateRobert H Newman (2013)
LIMK2_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANLIMK2_HUMANkinase -> substrateRegPhos
MRCKA_HUMANLIMK2_HUMANkinase -> substrateHPRD
ROCK1_HUMANLIMK2_HUMANkinase -> substrateRegPhos
LIMK2_HUMANCOF1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LIMK2_HUMANFAK2_HUMANkinase -> substrateRobert H Newman (2013)
LIMK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance
hsa04666Fc gamma R-mediated phagocytosis
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0005801cis-Golgi networkIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005634nucleusTAScellular_component
GO:0007283spermatogenesisIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0042325regulation of phosphorylationIEAbiological_process
GO:0016310phosphorylationTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component


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