Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KCC2A_HUMAN
Description:calcium/calmodulin-dependent protein kinase II alpha [Source:HGNC Symbol;Acc:1460]
Location:chr5 q32
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T286MHRQEtVDCLKCaM-KII_alphaphosphoELM
T310TTMLAtRNFSGPhosphoSitePlus
T336SESTNtTIEDEPhosphoSitePlus; HPRD
T286MHRQEtVDCLKCaMK2aRegPhos
Y230IKAGAyDFPSPPkinasePhosphoSitePlus
T305KGAILtTMLATPhosphoSitePlus
T306GAILTtMLATRPhosphoSitePlus
T337ESTNTtIEDEDPhosphoSitePlus; RegPhos
S25GKGAFsVVRRCRegPhos
T286MHRQEtVDCLKPhosphoSitePlus; phosphoELM
S333KESSEsTNTTIPhosphoSitePlus; RegPhos
Y13RFTEEyQLFEEHPRD; RegPhos
T286MHRQEtVDCLKautocatalysis RegPhos
S275WISHRsTVASCRegPhos
S234AYDFPsPEWDTPkinasePhosphoSitePlus
T3TCTRHPRD
T253INKMLtINPSKphosphoELM
T10TCTRFtEEYQLHPRD
T286MHRQEtVDCLKCAMK2AHPRD
T253INKMLtINPSKPkinasePhosphoSitePlus
T334ESSEStNTTIEPhosphoSitePlus; HPRD; RegPhos
S331GVKESsESTNTPhosphoSitePlus
T305KGAILtTMLATCAMK2AHPRD
T305KGAILtTMLATCaMK2aRegPhos

Dephosphorylation site
KCC2A_HUMAN do not have dephosphorylation site.

Mutation site
KCC2A_HUMAN do not have mutation site.

Differential expressed protein
KCC2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KCC2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2A_HUMANDLG1_HUMANkinase -> substrateHPRD
KCC2A_HUMANATF6A_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANSMAD2_HUMANkinase -> substrateHPRD
KCC2A_HUMANNOS1_HUMANkinase -> substrateHPRD
KCC2A_HUMANETS1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANKCC2A_HUMANkinase -> substrateRegPhos
KCC2A_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANTAU_HUMANkinase -> substrateHPRD
KCC2A_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANKCC2A_HUMANkinase -> substrateHPRD
KCC2A_HUMANCEBPB_HUMANkinase -> substrateHPRD
KCC2A_HUMANLRRC7_HUMANkinase -> substrateHPRD
KCC2A_HUMANNMDE1_HUMANkinase -> substrateHPRD
KCC2A_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANKCC2A_HUMANkinase -> substrateRobert H Newman (2013)
GRK5_HUMANKCC2A_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANITBP1_HUMANkinase -> substrateHPRD
KCC2A_HUMANPHOS_HUMANkinase -> substrateHPRD
KCC2A_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)
M3K14_HUMANKCC2A_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANGFAP_HUMANkinase -> substrateHPRD
KCC2A_HUMANK1C18_HUMANkinase -> substrateHPRD
KCC2A_HUMANEGFR_HUMANkinase -> substrateHPRD
KCC2A_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANCLAT_HUMANkinase -> substrateHPRD
KCC2A_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANHSF1_HUMANkinase -> substrateHPRD
KCC2A_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANNMDE2_HUMANkinase -> substrateHPRD
KCC2A_HUMANAT2A2_HUMANkinase -> substrateHPRD
KCC2A_HUMANSRF_HUMANkinase -> substrateHPRD
KCC2A_HUMANSYGP1_HUMANkinase -> substrateHPRD
PLCG1_HUMANKCC2A_HUMANotherKEGG
PLCB1_HUMANKCC2A_HUMANotherKEGG
CALL6_HUMANKCC2A_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04971Gastric acid secretion
hsa04012ErbB signaling pathway
hsa04720Long-term potentiation
hsa04114Oocyte meiosis
hsa05152Tuberculosis
hsa04912GnRH signaling pathway
hsa04740Olfactory transduction
hsa04916Melanogenesis
hsa04722Neurotrophin signaling pathway
hsa04728Dopaminergic synapse
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa04725Cholinergic synapse
hsa05031Amphetamine addiction
hsa05214Glioma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0016301kinase activityIDAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0046928regulation of neurotransmitter secretionIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0048168regulation of neuronal synaptic plasticityIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0035254glutamate receptor bindingIEAmolecular_function
GO:0006816calcium ion transportIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004683calmodulin-dependent protein kinase activityIEAmolecular_function
GO:0042734presynaptic membraneIEAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23