Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CBP_HUMAN
Description:CREB binding protein [Source:HGNC Symbol;Acc:2348]
Location:chr16 p13.3
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1754LDDEGsSQGEPPhosphoSitePlus
S274ITGNTsPFGQPHPRD
S2364PHSSPsPRIQPPhosphoSitePlus
S2079LKSPSsPQQQQCreb_binding; Npa1PhosphoSitePlus; SysPTM
Y659LAEKIyKIQKEKIXPhosphoSitePlus
S93NVSASsPVQQGPhosphoSitePlus
S2377SPHHVsPQTGSHPRD
S1763EPQSKsPQESRHPRD
S437PLKNAsDKRNQPKCdRegPhos
S78LLRGGsGSSINPhosphoSitePlus
S2063PPRSIsPSALQHPRD; phosphoELM; RegPhos; SysPTM
S2079LKSPSsPQQQQHPRD; phosphoELM; SysPTM
T1874MATMNtRNVPQPhosphoSitePlus
Y1450LRTAVyHEILIKAT11PhosphoSitePlus
S1771ESRRLsIQRCIHPRD
S2372IQPQPsPHHVSHPRD
S302LASKQsMVNSLCaMK4RegPhos
S1578ETTEGsQGDSKKAT11PhosphoSitePlus
T1171LYNRKtSRVYKBromodomainPhosphoSitePlus
S129SQGDSsAPSLPPhosphoSitePlus
S302LASKQsMVNSLCaM-KIVphosphoELM
S1386DSGEMsESFPYKAT11PhosphoSitePlus
S2322QQHMLsGQPQAHPRD
S2394VTMASsIDQGHHPRD
Y1460IGYLEyVKKLGKAT11PhosphoSitePlus
T1569KKEEStAASETKAT11PhosphoSitePlus
Y1973QQQHLyRVNINPhosphoSitePlus
S1568RKKEEsTAASEKAT11PhosphoSitePlus
T1001EMKTEtQAEDTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S437PLKNAsDKRNQPKC_groupphosphoELM; RegPhos
S2425LSSELsLVGDTPhosphoSitePlus
T2390PGLAVtMASSIHPRD
S1755DDEGSsQGEPQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1382SRFVDsGEMSEKAT11PhosphoSitePlus
S1076ASQSTsPSQPRPhosphoSitePlus; HPRD
S2063PPRSIsPSALQCreb_binding; Npa1PhosphoSitePlus; SysPTM
S121SAMGKsPLSQGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S2078TLKSPsSPQQQHPRD; phosphoELM
S2406GNPEQsAMLPQPhosphoSitePlus; HPRD
S2076LRTLKsPSSPQCreb_binding; Npa1PhosphoSitePlus
S2382SPQTGsPHPGLHPRD
S1030DLQGAsQVKEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1391SESFPyRTKALKAT11PhosphoSitePlus
S437PLKNAsDKRNQPhosphoSitePlus
Y1622LSQKLyATMEKKAT11PhosphoSitePlus
S1072SNGTAsQSTSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S2041PRPVIsMQAQACreb_bindingPhosphoSitePlus
S124GKSPLsQGDSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S2065RSISPsALQDLCreb_binding; Npa1PhosphoSitePlus
Y1457EILIGyLEYVKKAT11PhosphoSitePlus
S437PLKNAsDKRNQPRKCDHPRD
S302LASKQsMVNSLCAMK4HPRD
S2076LRTLKsPSSPQHPRD; phosphoELM

Dephosphorylation site
CBP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262367V406LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000262367Q1500PCOSMICLymphoma21390130
ENSP00000262367Y1622CCOSMICLymphoma21390126
ENSP00000262367N984HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000262367Y1503DCOSMICLymphoma21390126
ENSP00000262367R386*COSMICLymphoma21390130
ENSP00000262367R714HCOSMICLymphoma21390130
ENSP00000262367R1341QCOSMICLymphoma21390126
ENSP00000262367Q2208HCOSMICLymphoma21390130
ENSP00000262367I1453TCOSMICOvarian Cancer21720365
ENSP00000262367P2369TCOSMICLymphoma21390130
ENSP00000262367P858SCOSMICLymphoma21390130
ENSP00000262367Q752*COSMICLymphoma21390126
ENSP00000262367Q1079HCOSMICLymphoma21390126
ENSP00000262367Q1579*COSMICOvarian Cancer20668451
ENSP00000262367P1053LCOSMICLymphoma21390126
ENSP00000262367T950MCOSMICHead and Neck Cancer21798893
ENSP00000262367M1625LCOSMICLymphoma21390130
ENSP00000262367F1379VCOSMICOvarian Cancer21720365
ENSP00000262367G1069SCOSMICLymphoma21390130
ENSP00000262367E2440KCOSMICMelanoma21499247
ENSP00000262367A467TCOSMICOvarian Cancer15937088
ENSP00000262367I1483SCOSMICLymphoma21390126
ENSP00000262367L470*COSMICLymphoma21390130
ENSP00000262367A884TCOSMICOvarian Cancer21720365
ENSP00000262367A2281TCOSMICPancreatic Cancer
ENSP00000262367K1320RCOSMICLymphoma21390126
ENSP00000262367A2243TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000262367P937SCOSMICMelanoma
ENSP00000262367Q2140*COSMICLymphoma21390130
ENSP00000262367P2313LCOSMICLymphoma21390130
ENSP00000262367S709FCOSMICMelanoma21499247
ENSP00000262367D1435GCOSMICLymphoma21390126
ENSP00000262367Y1450CCOSMICLymphoma21390126
ENSP00000262367W1502CCOSMICLymphoma21390126
ENSP00000262367Q96*COSMICLymphoma21390126
ENSP00000262367A254TCOSMICLymphoma21390130
ENSP00000262367S893LCOSMICBreast Cancer15937088
ENSP00000262367Q156*COSMICLymphoma21390126
ENSP00000262367L1499PCOSMICLymphoma21390126
ENSP00000262367N563KCOSMICMelanoma21499247
ENSP00000262367I2101MCOSMICLymphoma21390130
ENSP00000262367N83TCOSMICLung Cancer
ENSP00000262367G2229SCOSMICLymphoma21390130
ENSP00000262367L1090*COSMICLymphoma21390130
ENSP00000262367R1563SCOSMICLymphoma21390130
ENSP00000262367C1408YCOSMICLymphoma21390130
ENSP00000262367R75*COSMICLymphoma21390126
ENSP00000262367S1761*COSMICLymphoma21390130
ENSP00000262367Q503*COSMICHead and Neck Cancer21798893
ENSP00000262367S1887*COSMICLymphoma21390130
ENSP00000262367R1446HCOSMICHead and Neck Cancer21798893
ENSP00000262367H253LCOSMICMelanoma21499247
ENSP00000262367P1476RCOSMICLymphoma21390126
ENSP00000262367Q786KCOSMICSkin Cancer21984974
ENSP00000262367N1978DCOSMICBreast Cancer15937088
ENSP00000262367L1689FCOSMICLymphoma21390130
ENSP00000262367C1240RCOSMICLymphoma21390126
ENSP00000262367P688ACOSMICLymphoma21390130
ENSP00000262367S2377LCOSMICLung Cancer20668451
ENSP00000262367Y1482HCOSMICLymphoma21390126
ENSP00000262367Y1125*COSMICLymphoma21390126
ENSP00000262367D1521YCOSMICHead and Neck Cancer21798893
ENSP00000262367L1338SCOSMICOvarian Cancer21720365
ENSP00000262367R1341*COSMICOvarian Cancer21720365
ENSP00000262367P993fs*5COSMICOvarian Cancer21720365
ENSP00000262367H1487YCOSMICLymphoma21390126
ENSP00000262367K1323*COSMICLymphoma21390126
ENSP00000262367L1434PCOSMICLymphoma21390126
ENSP00000262367R1360*COSMICLymphoma21390126
ENSP00000262367Q232*COSMICLymphoma21390126
ENSP00000262367R1173*COSMICLymphoma21390126
ENSP00000262367A1071TCOSMICOvarian Cancer15937088
ENSP00000262367C1237YCOSMICLymphoma21390130
ENSP00000262367A1354VCOSMICOvarian Cancer15937088
ENSP00000262367Y1234*COSMICLymphoma21390126

Differential expressed protein
CBP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CBP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANCBP_HUMANkinase -> substrateHPRD
ZAGL2_HUMANCBP_HUMANkinase -> substrateRegPhos
KCC4_HUMANCBP_HUMANkinase -> substrateHPRD
CBP_HUMANP53_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa05168Herpes simplex infection
hsa04520Adherens junction
hsa05211Renal cell carcinoma
hsa04720Long-term potentiation
hsa05166HTLV-I infection
hsa04310Wnt signaling pathway
hsa04110Cell cycle
hsa05164Influenza A
hsa05203Viral carcinogenesis
hsa05200Pathways in cancer
hsa05152Tuberculosis
hsa05169Epstein-Barr virus infection
hsa04916Melanogenesis
hsa05215Prostate cancer
hsa04330Notch signaling pathway
hsa04350TGF-beta signaling pathway
hsa05016Huntington's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033554cellular response to stressTASbiological_process
GO:0042592homeostatic processNASbiological_process
GO:0016407acetyltransferase activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0045087innate immune responseTASbiological_process
GO:0001078RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0071456cellular response to hypoxiaTASbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0002039p53 bindingIPImolecular_function
GO:0008589regulation of smoothened signaling pathwayTASbiological_process
GO:0030718germ-line stem cell maintenanceIEAbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0016604nuclear bodyIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0001191RNA polymerase II transcription factor binding traIDAmolecular_function
GO:0018076N-terminal peptidyl-lysine acetylationIDAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0061418regulation of transcription from RNA polymerase IITASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0000987core promoter proximal region sequence-specific DNIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0042733embryonic digit morphogenesisTASbiological_process
GO:0001102RNA polymerase II activating transcription factor TASmolecular_function
GO:0001105RNA polymerase II transcription coactivator activiTASmolecular_function
GO:0000123histone acetyltransferase complexIEAcellular_component
GO:0001666response to hypoxiaTASbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0016407acetyltransferase activityIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004871signal transducer activityTASmolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0016573histone acetylationIDAbiological_process
GO:0003712transcription cofactor activityIEAmolecular_function
GO:0000940condensed chromosome outer kinetochoreIEAcellular_component
GO:0043426MRF bindingIDAmolecular_function
GO:0007165signal transductionNASbiological_process
GO:0005634nucleusICcellular_component
GO:0004402histone acetyltransferase activityIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process