| UniProt/SwissProt ID: | PI3R4_HUMAN |
| Description: | phosphoinositide-3-kinase, regulatory subunit 4 [Source:HGNC Symbol;Acc:8982] |
| Location: | chr3 q22.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S813 | SHLHDsSQKGV | PhosphoSitePlus; HPRD | |
| S740 | SKDITsLFRHL | PhosphoSitePlus | |
| S1287 | STSSPsVSYYR | HPRD | |
| S1282 | YVVAGsTSSPS | HPRD | |
| S865 | KSMFGsLDPPN | PhosphoSitePlus; HPRD; SysPTM | |
| S1079 | SKLPKsPKIHP | PhosphoSitePlus | |
| Y1291 | PSVSYyRKIIE | PhosphoSitePlus; HPRD | |
| Y1038 | RSILTySRIGG | HPRD | |
| S814 | HLHDSsQKGVI | PhosphoSitePlus; HPRD | |
| T680 | AVGFItVVARQ | PhosphoSitePlus | |
| S926 | IPVLSsTILPS | HPRD | |
| S931 | STILPsTYQIR | HPRD | |
| S853 | HVKQDsNVNEE | PhosphoSitePlus; HPRD; SysPTM | |
| T942 | ITTCKtELQQL | PhosphoSitePlus | |
| S861 | NEEWKsMFGSL | PhosphoSitePlus | |
| T1316 | GPSDDtPRRGP | PhosphoSitePlus; HPRD; SysPTM | |
| S1074 | LGIEAsKLPKS | PhosphoSitePlus | |
| T927 | PVLSStILPST | PhosphoSitePlus; HPRD | |
| Y1272 | FWDLAyPERSY | PhosphoSitePlus | |
| S894 | PPRSEsSAGIC | HPRD | |
| T1283 | VVAGStSSPSV | PhosphoSitePlus; HPRD | |
| Y673 | NLWIRyGAVGF | PhosphoSitePlus; HPRD | |
| S808 | NIVDQsHLHDS | PhosphoSitePlus | |
| S1289 | SSPSVsYYRKI | HPRD | |
| T61 | AIQDPtLPLTS | Pkinase | PhosphoSitePlus |
| S925 | VIPVLsSTILP | PhosphoSitePlus; phosphoELM | |
| Y1290 | SPSVSyYRKII | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| PI3R4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000349205 | Q934E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000349205 | I1255V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000349205 | V1045I | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000349205 | R936Q | BIOMART, HPI | Breast Cancer | 21930507, 21930502, 16959974 | ENSP00000349205 | R936Q | Sjoblom2006 | Breast Cancer | 16959974 |
| Differential expressed protein |
| PI3R4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PI3R4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PI3R4_HUMAN | PK3CG_HUMAN | kinase -> substrate | RegPhos |
| PI3R4_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PI3R4_HUMAN | KPCD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PI3R4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04140 | Regulation of autophagy |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0004672 | protein kinase activity | NAS | molecular_function |
| GO:0005770 | late endosome | IDA | cellular_component |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0006468 | protein phosphorylation | NAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |