Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PI3R4_HUMAN
Description:phosphoinositide-3-kinase, regulatory subunit 4 [Source:HGNC Symbol;Acc:8982]
Location:chr3 q22.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S813SHLHDsSQKGVPhosphoSitePlus; HPRD
S740SKDITsLFRHLPhosphoSitePlus
S1287STSSPsVSYYRHPRD
S1282YVVAGsTSSPSHPRD
S865KSMFGsLDPPNPhosphoSitePlus; HPRD; SysPTM
S1079SKLPKsPKIHPPhosphoSitePlus
Y1291PSVSYyRKIIEPhosphoSitePlus; HPRD
Y1038RSILTySRIGGHPRD
S814HLHDSsQKGVIPhosphoSitePlus; HPRD
T680AVGFItVVARQPhosphoSitePlus
S926IPVLSsTILPSHPRD
S931STILPsTYQIRHPRD
S853HVKQDsNVNEEPhosphoSitePlus; HPRD; SysPTM
T942ITTCKtELQQLPhosphoSitePlus
S861NEEWKsMFGSLPhosphoSitePlus
T1316GPSDDtPRRGPPhosphoSitePlus; HPRD; SysPTM
S1074LGIEAsKLPKSPhosphoSitePlus
T927PVLSStILPSTPhosphoSitePlus; HPRD
Y1272FWDLAyPERSYPhosphoSitePlus
S894PPRSEsSAGICHPRD
T1283VVAGStSSPSVPhosphoSitePlus; HPRD
Y673NLWIRyGAVGFPhosphoSitePlus; HPRD
S808NIVDQsHLHDSPhosphoSitePlus
S1289SSPSVsYYRKIHPRD
T61AIQDPtLPLTSPkinasePhosphoSitePlus
S925VIPVLsSTILPPhosphoSitePlus; phosphoELM
Y1290SPSVSyYRKIIPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
PI3R4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000349205Q934EBIOMARTBreast Cancer21930507, 21930502
ENSP00000349205I1255VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000349205V1045IBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000349205R936QBIOMART, HPIBreast Cancer21930507, 21930502, 16959974
ENSP00000349205R936QSjoblom2006Breast Cancer16959974

Differential expressed protein
PI3R4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PI3R4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PI3R4_HUMANPK3CG_HUMANkinase -> substrateRegPhos
PI3R4_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
PI3R4_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
PI3R4_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04140Regulation of autophagy

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005488bindingIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0005524ATP bindingNASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0004672protein kinase activityNASmolecular_function
GO:0005770late endosomeIDAcellular_component
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0006468protein phosphorylationNASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function


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