Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:E2AK2_HUMAN
Description:eukaryotic translation initiation factor 2-alpha kinase 2 [Source:HGNC Symbol;Acc:9437]
Location:chr2 p22.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T451TRSKGtLRYMSPKRRegPhos
T535SEILRtLTVWKPkinasePhosphoSitePlus
S93TTTNSsEGLSMHPRD
T255PDMKEtKYTVDPKRRegPhos
T88SPLLLtTTNSSPKR(EIF2AK2RegPhos
T446NDGKRtRSKGTPKRRegPhos
T451TRSKGtLRYMSPkinasePhosphoSitePlus
Y101LSMGNyIGLINPKRRegPhos
T446NDGKRtRSKGTPkinasePhosphoSitePlus
S92LTTTNsSEGLSPhosphoSitePlus
S242RKAKRsLAPRFPhosphoSitePlus
T88SPLLLtTTNSSautocatalysis RegPhos
T88SPLLLtTTNSSEIF2AK2phosphoELM
T258KETKYtVDKRFPhosphoSitePlus
T90LLLTTtNSSEGPKR(EIF2AK2RegPhos
T89PLLLTtTNSSEEIF2AK2phosphoELM
T255PDMKEtKYTVDautocatalysis RegPhos
T451TRSKGtLRYMSautocatalysisRegPhos
S83EKKAVsPLLLTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y101LSMGNyIGLINEIF2AK2HPRD
S242RKAKRsLAPRFautocatalysis RegPhos
T451TRSKGtLRYMSPKR(EIF2AK2RegPhos
T255PDMKEtKYTVDEIF2AK2HPRD; phosphoELM
S181YLSSGsFATTCPhosphoSitePlus
Y162AAKLAyLQILSPKRRegPhos
T90LLLTTtNSSEGautocatalysis RegPhos
S83EKKAVsPLLLTautocatalysis RegPhos; SysPTM
Y293IDGKTyVIKRVPKRRegPhos
Y162AAKLAyLQILSEIF2AK2HPRD
S242RKAKRsLAPRFPKRRegPhos
T90LLLTTtNSSEGPhosphoSitePlus; HPRD; phosphoELM
Y293IDGKTyVIKRVPkinasePhosphoSitePlus
S242RKAKRsLAPRFEIF2AK2HPRD; phosphoELM
T89PLLLTtTNSSEPKR(EIF2AK2RegPhos
Y454KGTLRyMSPEQPkinasePhosphoSitePlus
T446NDGKRtRSKGTPKR(EIF2AK2RegPhos
T258KETKYtVDKRFautocatalysis RegPhos
S6MAGDLsAGFFMPhosphoSitePlus
Y101LSMGNyIGLINJAK1HPRD
T255PDMKEtKYTVDPhosphoSitePlus
S83EKKAVsPLLLTEIF2AK2phosphoELM; SysPTM
Y162AAKLAyLQILSdsrmPhosphoSitePlus
Y142MGQKEySIGTGdsrmPhosphoSitePlus
T255PDMKEtKYTVDPKR(EIF2AK2RegPhos
T451TRSKGtLRYMSEIF2AK2HPRD; phosphoELM
Y162AAKLAyLQILSphosphoELM; RegPhos
T446NDGKRtRSKGTEIF2AK2HPRD; phosphoELM
Y101LSMGNyIGLINphosphoELM; RegPhos
Y293IDGKTyVIKRVEIF2AK2HPRD
T258KETKYtVDKRFPKR(EIF2AK2RegPhos
Y101LSMGNyIGLINdsrmPhosphoSitePlus
T258KETKYtVDKRFEIF2AK2HPRD; phosphoELM
T88SPLLLtTTNSSPhosphoSitePlus
T90LLLTTtNSSEGEIF2AK2phosphoELM
T258KETKYtVDKRFPKRRegPhos
Y293IDGKTyVIKRVphosphoELM; RegPhos
T446NDGKRtRSKGTautocatalysisRegPhos
T89PLLLTtTNSSEautocatalysis RegPhos
S456TLRYMsPEQISHPRD; phosphoELM; SysPTM
S242RKAKRsLAPRFPKR(EIF2AK2RegPhos
S542TVWKKsPEKNEPhosphoSitePlus; HPRD
S456TLRYMsPEQISPkinasePhosphoSitePlus; SysPTM
T89PLLLTtTNSSEPhosphoSitePlus; HPRD
S179SDYLSsGSFATPhosphoSitePlus
S83EKKAVsPLLLTPKR(EIF2AK2RegPhos; SysPTM
Y293IDGKTyVIKRVJAK1HPRD

Dephosphorylation site
E2AK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378559L439VGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000378559I405TBIOMARTBreast Cancer21930507, 21930502
ENSP00000233057I405TBIOMARTBreast Cancer21930507, 21930502
ENSP00000233057L439VGreenman2007, HPILung Cancer17344846, 18428421

Differential expressed protein
E2AK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
E2AK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CHK2_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
IKKB_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANE2AK2_HUMANkinase -> substrateRegPhos
E2AK2_HUMANE2AK2_HUMANkinase -> substrateRegPhos
KC1E_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
E2AK2_HUMANIF2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
E2AK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
E2AK2_HUMANIKBA_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
M3K13_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
E2AK2_HUMANP53_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
TYK2_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
E2AK2_HUMANPLK1_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
JAK1_HUMANE2AK2_HUMANkinase -> substrateHPRD
E2AK2_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
E2AK2_HUMAN2A5A_HUMANkinase -> substrateHPRD; RegPhos
FYN_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05160Hepatitis C
hsa04141Protein processing in endoplasmic reticulum
hsa05168Herpes simplex infection
hsa05164Influenza A
hsa05169Epstein-Barr virus infection
hsa05162Measles
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003725double-stranded RNA bindingIEAmolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0004694eukaryotic translation initiation factor 2alpha kiTASmolecular_function
GO:0019058viral infectious cycleTASbiological_process
GO:0008601protein phosphatase type 2A regulator activityTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0030968endoplasmic reticulum unfolded protein responseIEAbiological_process
GO:0019048virus-host interactionTASbiological_process
GO:0030683evasion or tolerance by virus of host immune respoTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0019054modulation by virus of host cellular processTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0033689negative regulation of osteoblast proliferationIMPbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0006412translationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006926virus-infected cell apoptotic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0046777protein autophosphorylationIEAbiological_process


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