Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NCF1_HUMAN
Description:neutrophil cytosolic factor 1 [Source:HGNC Symbol;Acc:7660]
Location:chr7 q11.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S315SIHQRsRKRLSPhosphoSitePlus
S345RPGPQsPGSPLMAPK3phosphoELM
S348PQSPGsPLEEECK2_groupphosphoELM; RegPhos
S288SGQDVsQAQRQPhosphoSitePlus
S348PQSPGsPLEEEp38a(MAPK14RegPhos
S348PQSPGsPLEEEMAPK14phosphoELM
S328AYRRNsVRFLQAKT_groupRegPhos
S348PQSPGsPLEEEp47_phox_CPhosphoSitePlus
Y139KKPETyLMPKDPhosphoSitePlus
S320SRKRLsQDAYRPKA_groupphosphoELM; RegPhos
S304PPRRSsIRNAHPKC_alphaphosphoELM
S320SRKRLsQDAYRPhosphoSitePlus; RegPhos
S359RQTQRsKPQPAPKC_alphaphosphoELM
S345RPGPQsPGSPLMAPK14phosphoELM
S370VPPRPsADLILPKCa(PKC alphaRegPhos
S303APPRRsSIRNAPhosphoSitePlus; RegPhos
S320SRKRLsQDAYRPKC_alphaphosphoELM
S345RPGPQsPGSPLErk1(MAPK3RegPhos
T133PTDNQtKKPETPhosphoSitePlus
S208GWIPAsFLEPLPhosphoSitePlus
S304PPRRSsIRNAHAKT_groupRegPhos
T153TATDItGPIILPhosphoSitePlus
S328AYRRNsVRFLQPKC_alphaphosphoELM
S208GWIPAsFLEPLCK2_groupphosphoELM; RegPhos
S348PQSPGsPLEEEErk1(MAPK3RegPhos
S304PPRRSsIRNAHPKB_groupphosphoELM
S328AYRRNsVRFLQPKB_groupphosphoELM
S348PQSPGsPLEEEPKA_groupphosphoELM
S304PPRRSsIRNAHPhosphoSitePlus; RegPhos
S348PQSPGsPLEEEPKC_alphaphosphoELM
S315SIHQRsRKRLSPKCa(PKC alphaRegPhos
S348PQSPGsPLEEERegPhos
S328AYRRNsVRFLQPKCa(PKC alphaRegPhos
S304PPRRSsIRNAHPKCa(PKC alphaRegPhos
S310IRNAHsIHQRSPhosphoSitePlus
S359RQTQRsKPQPAPKCa(PKC alphaRegPhos
S370VPPRPsADLILPKA_groupphosphoELM; RegPhos
S379ILNRCsESTKRphosphoELM; RegPhos
S359RQTQRsKPQPAphosphoELM
S320SRKRLsQDAYRPKCa(PKC alphaRegPhos
Y279YFPSMyLQKSGPhosphoSitePlus
S328AYRRNsVRFLQPhosphoSitePlus; RegPhos
S370VPPRPsADLILp47_phox_CPhosphoSitePlus
S328AYRRNsVRFLQPKA_groupphosphoELM; RegPhos
S315SIHQRsRKRLSPKC_alphaphosphoELM
S359RQTQRsKPQPAPKA_groupphosphoELM; RegPhos
S370VPPRPsADLILphosphoELM
S303APPRRsSIRNAPKCa(PKC alphaRegPhos
S345RPGPQsPGSPLp47_phox_CPhosphoSitePlus
S303APPRRsSIRNAPKA_groupphosphoELM
S345RPGPQsPGSPLphosphoELM; RegPhos
T138TKKPEtYLMPKPhosphoSitePlus
Y48RFTEIyEFHKTPXPhosphoSitePlus
S379ILNRCsESTKRp47_phox_CPhosphoSitePlus
T45VYRRFtEIYEFPXPhosphoSitePlus
S303APPRRsSIRNAPKC_alphaphosphoELM
Y41SEKVVyRRFTEPXPhosphoSitePlus
T356EEERQtQRSKPp47_phox_CPhosphoSitePlus
S370VPPRPsADLILPKC_alphaphosphoELM
S359RQTQRsKPQPAp47_phox_CPhosphoSitePlus
S283MYLQKsGQDVSCK2_groupphosphoELM; RegPhos
S345RPGPQsPGSPLp38a(MAPK14RegPhos
S283MYLQKsGQDVSPhosphoSitePlus
S348PQSPGsPLEEEMAPK3phosphoELM

Dephosphorylation site
NCF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000289473V30MCOSMICSkin Cancer21984974
ENSP00000289473S109FCOSMICSkin Cancer21984974
ENSP00000289473E218KCOSMICMelanoma21499247

Differential expressed protein
NCF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NCF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNCF1_HUMANkinase -> substrateRegPhos
MK14_HUMANNCF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANNCF1_HUMANkinase -> substrateNetPath
MK03_HUMANNCF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANNCF1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05140Leishmaniasis
hsa04666Fc gamma R-mediated phagocytosis
hsa04145Phagosome
hsa04670Leukocyte transendothelial migration
hsa04062Chemokine signaling pathway
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051701interaction with hostTASbiological_process
GO:0005525GTP bindingTASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0042554superoxide anion generationTASbiological_process
GO:0035091phosphatidylinositol bindingIDAmolecular_function
GO:0006968cellular defense responseIEAbiological_process
GO:0006612protein targeting to membraneIDAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0016175superoxide-generating NADPH oxidase activityIEAmolecular_function
GO:0009055electron carrier activityTASmolecular_function
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0017124SH3 domain bindingIPImolecular_function
GO:0045730respiratory burstIEAbiological_process
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0045730respiratory burstTASbiological_process
GO:0042742defense response to bacteriumIEAbiological_process
GO:0043020NADPH oxidase complexTAScellular_component
GO:0050832defense response to fungusIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0002679respiratory burst involved in defense responseIEAbiological_process
GO:0045986negative regulation of smooth muscle contractionIEAbiological_process
GO:0006691leukotriene metabolic processIEAbiological_process
GO:0070947neutrophil mediated killing of fungusIEAbiological_process
GO:0007154cell communicationIEAbiological_process
GO:0001909leukocyte mediated cytotoxicityIEAbiological_process
GO:0070946neutrophil mediated killing of gram-positive bacteIEAbiological_process
GO:0001878response to yeastIEAbiological_process
GO:0006184GTP catabolic processTASbiological_process
GO:0090382phagosome maturationTASbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0032010phagolysosomeTAScellular_component
GO:0006801superoxide metabolic processTASbiological_process
GO:0042554superoxide anion generationIEAbiological_process
GO:0050665hydrogen peroxide biosynthetic processIEAbiological_process


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