Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TYRO3_HUMAN
Description:TYRO3 protein tyrosine kinase [Source:HGNC Symbol;Acc:12446]
Location:chr15 q15.1
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T427PPHSRtSWVPVPhosphoSitePlus
S682SRKIYsGDYYRPkinase_TyrPhosphoSitePlus
S428PHSRTsWVPVVPhosphoSitePlus
S835GAGDGsGMGAVPhosphoSitePlus
Y686YSGDYyRQGCAPkinase_TyrPhosphoSitePlus
S869EHQPEsPLNETHPRD
Y681LSRKIySGDYYPkinase_TyrPhosphoSitePlus
Y685IYSGDyYRQGCPkinase_TyrPhosphoSitePlus
Y828GRDQPySGAGDPhosphoSitePlus

Dephosphorylation site
TYRO3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263798G542STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000263798E348*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263798N623KDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263798A273GTCGAOvarian Cancer21720365, 18772890
ENSP00000263798P228STCGAOvarian Cancer21720365, 18772890
ENSP00000263798V580LCOSMICHead and Neck Cancer21798893
ENSP00000263798G675RCOSMICGastric Cancer21097718

Differential expressed protein
TYRO3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TYRO3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GAS6_HUMANTYRO3_HUMANligand -> receptorHPMR
PROS_HUMANTYRO3_HUMANligand -> receptorHPMR
TYRO3_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANPRIO_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANPLCG1_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TYRO3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0060068vagina developmentIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0070527platelet aggregationIEAbiological_process
GO:0021885forebrain cell migrationIEAbiological_process
GO:0042698ovulation cycleIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043548phosphatidylinositol 3-kinase bindingIPImolecular_function
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actNASmolecular_function
GO:0007283spermatogenesisIEAbiological_process
GO:0032940secretion by cellIEAbiological_process
GO:0070050neuron homeostasisIEAbiological_process
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0030168platelet activationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0014065phosphatidylinositol 3-kinase cascadeNASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0001779natural killer cell differentiationIEAbiological_process
GO:0005635nuclear envelopeISScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0030168platelet activationISSbiological_process
GO:0051250negative regulation of lymphocyte activationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0043277apoptotic cell clearanceIEAbiological_process
GO:0005887integral to plasma membraneNAScellular_component
GO:0045824negative regulation of innate immune responseIEAbiological_process
GO:0034122negative regulation of toll-like receptor signalinIEAbiological_process
GO:0004716receptor signaling protein tyrosine kinase activitNASmolecular_function
GO:0005789endoplasmic reticulum membraneISScellular_component
GO:0023014signal transduction by phosphorylationNASbiological_process
GO:0007165signal transductionNASbiological_process
GO:0007155cell adhesionNASbiological_process
GO:0005634nucleusISScellular_component
GO:0034446substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function


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