Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MUC1_HUMAN
Description:mucin 1, cell surface associated [Source:HGNC Symbol;Acc:7508]
Location:chr1 q22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1202FPARDtYHPMSRhabdo_glycop; IncAPhosphoSitePlus
Y160SEYPTyHTHGRHPRD
Y209CRRKNyGQLDIHPRD
Y1209HPMSEyPTYHTphosphoELM
S1227SSTDRsPYEKVPhosphoSitePlus
Y1209HPMSEyPTYHTIncAPhosphoSitePlus
Y1229TDRSPyEKVSACSKRegPhos
Y1243GSSLSyTNPAVAblphosphoELM
Y230SEYPTyHTHGRHPRD
Y177TDRSPyEKVSAHPRD
S1240GNGGSsLSYTNPhosphoSitePlus
S1233PYEKVsAGNGGPhosphoSitePlus
S1227SSTDRsPYEKVGSK-3_betaphosphoELM
Y1191CRRKNyGQLDIRhabdo_glycop; IncAPhosphoSitePlus
Y1203PARDTyHPMSEphosphoELM; RegPhos
Y1203PARDTyHPMSEPDGFR_groupRegPhos
Y1212SEYPTyHTHGRIncAPhosphoSitePlus
T1224VPPSStDRSPYPhosphoSitePlus
Y221PARDTyHPMSEHPRD
Y1191CRRKNyGQLDIphosphoELM
T224TSAPDtRPAPGPKCdRegPhos
T242VPPSStDRSPYPRKCDHPRD
Y227HPMSEyPTYHTHPRD
T1214YPTYHtHGRYVIncAPhosphoSitePlus
Y1229TDRSPyEKVSAEGFRphosphoELM; RegPhos
Y1229TDRSPyEKVSASrcRegPhos
Y157HPMSEyPTYHTHPRD
Y139CRRKNyGQLDIHPRD
Y1229TDRSPyEKVSASRCphosphoELM; RegPhos
Y1229TDRSPyEKVSAZAP70RegPhos
Y191GSSLSyTNPAVHPRD
S1223YVPPSsTDRSPIncAPhosphoSitePlus
Y1203PARDTyHPMSEIncAPhosphoSitePlus
T1224VPPSStDRSPYPKCdRegPhos
Y1212SEYPTyHTHGRphosphoELM; RegPhos
Y1243GSSLSyTNPAVABL1RegPhos
S1242GGSSLsYTNPAPhosphoSitePlus
Y247TDRSPyEKVSAEGFRHPRD
T1224VPPSStDRSPYPKC_deltaphosphoELM
S245SSTDRsPYEKVGSK3BHPRD
S1227SSTDRsPYEKVGSK3B(GSK3 betaRegPhos
Y1243GSSLSyTNPAVPhosphoSitePlus; phosphoELM; RegPhos
S1222RYVPPsSTDRSIncAPhosphoSitePlus
Y261GSSLSyTNPAVHPRD
Y1218HTHGRyVPPSSIncAPhosphoSitePlus
T1244SSLSYtNPAVAPhosphoSitePlus
S1207TYHPMsEYPTYIncAPhosphoSitePlus
Y151PARDTyHPMSEHPRD
T1224VPPSStDRSPYPKCd(PKC deltaRegPhos
Y1218HTHGRyVPPSSPDGFR_groupRegPhos
T1211MSEYPtYHTHGIncAPhosphoSitePlus
Y1218HTHGRyVPPSSphosphoELM
Y1229TDRSPyEKVSAPhosphoSitePlus; phosphoELM
S1227SSTDRsPYEKVGSK3BRegPhos

Dephosphorylation site
MUC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000338983P79SCOSMICMelanoma21499247
ENSP00000338983R244HSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000338983T137KCOSMICPancreatic Cancer
ENSP00000338983V194ACOSMICBreast Cancer20668451

Differential expressed protein
MUC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y1212IncAPMSEYPTyHTHGRYVcholangiocellular carcinoma21253578PhosphoSitePlus
Y1209IncATYHPMSEyPTYHTHGcholangiocellular carcinoma21253578PhosphoSitePlus
Y1203IncAIFPARDTyHPMSEYPcholangiocellular carcinoma21253578PhosphoSitePlus
Y1229SSTDRSPyEKVSAGNcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANMUC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
LCK_HUMANMUC1_HUMANkinase -> substrateNetPath
CSK_HUMANMUC1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMUC1_HUMANkinase -> substrateRegPhos
PGFRB_HUMANMUC1_HUMANkinase -> substrateRegPhos
ZAP70_HUMANMUC1_HUMANkinase -> substrateHPRD; RegPhos; NetPath
SRC_HUMANMUC1_HUMANkinase -> substrateRegPhos
GSK3B_HUMANMUC1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ABL1_HUMANMUC1_HUMANkinase -> substrateRegPhos
EGFR_HUMANMUC1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
MUC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009986cell surfaceIBAcellular_component
GO:0000978RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0000790nuclear chromatinIDAcellular_component
GO:0003712transcription cofactor activityIDAmolecular_function
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0005737cytoplasmIBAcellular_component
GO:0002039p53 bindingIPImolecular_function
GO:0005796Golgi lumenTAScellular_component
GO:0010944negative regulation of transcription by competitivIDAbiological_process
GO:0036003positive regulation of transcription from RNA polyIDAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 clIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 clIDAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0090240positive regulation of histone H4 acetylationIDAbiological_process
GO:0016324apical plasma membraneIBAcellular_component
GO:0043687post-translational protein modificationTASbiological_process
GO:0016266O-glycan processingTASbiological_process
GO:0043618regulation of transcription from RNA polymerase IIIDAbiological_process


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