| UniProt/SwissProt ID: | KS6B2_HUMAN |
| Description: | ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Source:HGNC Symbol;Acc:10437] |
| Location: | chr11 q13.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T228 | GAVTHtFCGTI | Pkinase | PhosphoSitePlus |
| T388 | AFLGFtYVAPS | MTOR | HPRD |
| T388 | AFLGFtYVAPS | mTOR | phosphoELM |
| S473 | SGTKKsKRGRG | PKC_gamma | phosphoELM |
| S417 | RRLNSsPRAPV | PhosphoSitePlus | |
| T228 | GAVTHtFCGTI | MTOR | HPRD |
| S473 | SGTKKsKRGRG | PKCi | RegPhos |
| T226 | HEGAVtHTFCG | Pkinase | PhosphoSitePlus |
| S356 | SEEDVsQFDTR | Pkinase_C | PhosphoSitePlus |
| S473 | SGTKKsKRGRG | PKCd(PKC delta | RegPhos |
| S370 | QTPVDsPDDTA | MTOR | HPRD |
| S473 | SGTKKsKRGRG | PKC_delta | phosphoELM |
| Y136 | IVELAyAFQTG | Pkinase | PhosphoSitePlus |
| S356 | SEEDVsQFDTR | HPRD; phosphoELM; RegPhos | |
| Y45 | EPVGHyEEVEL | PhosphoSitePlus | |
| S473 | SGTKKsKRGRG | PKCg(PKC gamma | RegPhos |
| S410 | QPKLRsPRRLN | PhosphoSitePlus | |
| S473 | SGTKKsKRGRG | PKC_iota | phosphoELM |
| S473 | SGTKKsKRGRG | PKC_epsilon | phosphoELM |
| S416 | PRRLNsSPRAP | PhosphoSitePlus | |
| T388 | AFLGFtYVAPS | PDK1 | RegPhos |
| S473 | SGTKKsKRGRG | PKC_zeta | phosphoELM |
| S15 | ETEEGsEGEGE | HPRD; phosphoELM; RegPhos | |
| S473 | SGTKKsKRGRG | PKCb(PKC beta | RegPhos |
| T228 | GAVTHtFCGTI | FRAP | RegPhos |
| Y96 | NLGKIyAMKVL | Pkinase | PhosphoSitePlus |
| S473 | SGTKKsKRGRG | PKCe(PKC epsilon | RegPhos |
| S370 | QTPVDsPDDTA | PDK1 | RegPhos |
| T270 | GSPPFtAENRK | Pkinase | PhosphoSitePlus |
| T388 | AFLGFtYVAPS | FRAP(mTOR | RegPhos |
| S219 | GLCKEsIHEGA | Pkinase | PhosphoSitePlus |
| T388 | AFLGFtYVAPS | PDPK1 | HPRD |
| S266 | DMLTGsPPFTA | Pkinase | PhosphoSitePlus |
| S370 | QTPVDsPDDTA | FRAP | RegPhos |
| S473 | SGTKKsKRGRG | PKCz(PKC zeta | RegPhos |
| T228 | GAVTHtFCGTI | PDK1 | RegPhos |
| S473 | SGTKKsKRGRG | PKC_beta | phosphoELM |
| S473 | SGTKKsKRGRG | PKCa(PKC alpha | RegPhos |
| S473 | SGTKKsKRGRG | PKC_alpha | phosphoELM |
| S473 | SGTKKsKRGRG | PhosphoSitePlus | |
| S370 | QTPVDsPDDTA | PDPK1 | HPRD |
| S423 | PRAPVsPLKFS | PhosphoSitePlus | |
| T388 | AFLGFtYVAPS | FRAP | RegPhos |
| T228 | GAVTHtFCGTI | PDPK1 | HPRD |
| Dephosphorylation site |
| KS6B2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000308413 | T443M | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 | ENSP00000308413 | I233T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000308413 | S356G | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 |
| Differential expressed protein |
| KS6B2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KS6B2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6B2_HUMAN | K1C18_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCI_HUMAN | KS6B2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MTOR_HUMAN | KS6B2_HUMAN | kinase -> substrate | RegPhos |
| KS6B2_HUMAN | GNA12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | KS6B2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B2_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B2_HUMAN | HSPB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCD_HUMAN | KS6B2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | KS6B2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B2_HUMAN | ETS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | KS6B2_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | KS6B2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04150 | mTOR signaling pathway |
| hsa04910 | Insulin signaling pathway |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa04012 | ErbB signaling pathway |
| hsa04350 | TGF-beta signaling pathway |
| hsa05221 | Acute myeloid leukemia |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006412 | translation | TAS | biological_process |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0043491 | protein kinase B signaling cascade | IEA | biological_process |
| GO:0048015 | phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0042277 | peptide binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0045948 | positive regulation of translational initiation | IMP | biological_process |
| GO:0004711 | ribosomal protein S6 kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |