Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KS6B2_HUMAN
Description:ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Source:HGNC Symbol;Acc:10437]
Location:chr11 q13.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T228GAVTHtFCGTIPkinasePhosphoSitePlus
T388AFLGFtYVAPSMTORHPRD
T388AFLGFtYVAPSmTORphosphoELM
S473SGTKKsKRGRGPKC_gammaphosphoELM
S417RRLNSsPRAPVPhosphoSitePlus
T228GAVTHtFCGTIMTORHPRD
S473SGTKKsKRGRGPKCiRegPhos
T226HEGAVtHTFCGPkinasePhosphoSitePlus
S356SEEDVsQFDTRPkinase_CPhosphoSitePlus
S473SGTKKsKRGRGPKCd(PKC deltaRegPhos
S370QTPVDsPDDTAMTORHPRD
S473SGTKKsKRGRGPKC_deltaphosphoELM
Y136IVELAyAFQTGPkinasePhosphoSitePlus
S356SEEDVsQFDTRHPRD; phosphoELM; RegPhos
Y45EPVGHyEEVELPhosphoSitePlus
S473SGTKKsKRGRGPKCg(PKC gammaRegPhos
S410QPKLRsPRRLNPhosphoSitePlus
S473SGTKKsKRGRGPKC_iotaphosphoELM
S473SGTKKsKRGRGPKC_epsilonphosphoELM
S416PRRLNsSPRAPPhosphoSitePlus
T388AFLGFtYVAPSPDK1RegPhos
S473SGTKKsKRGRGPKC_zetaphosphoELM
S15ETEEGsEGEGEHPRD; phosphoELM; RegPhos
S473SGTKKsKRGRGPKCb(PKC betaRegPhos
T228GAVTHtFCGTIFRAPRegPhos
Y96NLGKIyAMKVLPkinasePhosphoSitePlus
S473SGTKKsKRGRGPKCe(PKC epsilonRegPhos
S370QTPVDsPDDTAPDK1RegPhos
T270GSPPFtAENRKPkinasePhosphoSitePlus
T388AFLGFtYVAPSFRAP(mTORRegPhos
S219GLCKEsIHEGAPkinasePhosphoSitePlus
T388AFLGFtYVAPSPDPK1HPRD
S266DMLTGsPPFTAPkinasePhosphoSitePlus
S370QTPVDsPDDTAFRAPRegPhos
S473SGTKKsKRGRGPKCz(PKC zetaRegPhos
T228GAVTHtFCGTIPDK1RegPhos
S473SGTKKsKRGRGPKC_betaphosphoELM
S473SGTKKsKRGRGPKCa(PKC alphaRegPhos
S473SGTKKsKRGRGPKC_alphaphosphoELM
S473SGTKKsKRGRGPhosphoSitePlus
S370QTPVDsPDDTAPDPK1HPRD
S423PRAPVsPLKFSPhosphoSitePlus
T388AFLGFtYVAPSFRAPRegPhos
T228GAVTHtFCGTIPDPK1HPRD

Dephosphorylation site
KS6B2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000308413T443MGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000308413I233TTCGAOvarian Cancer21720365, 18772890
ENSP00000308413S356GBIOMARTchronic lymphocytic leukemia21930507, 21930502

Differential expressed protein
KS6B2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KS6B2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6B2_HUMANK1C18_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANKS6B2_HUMANkinase -> substrateRobert H Newman (2013)
MTOR_HUMANKS6B2_HUMANkinase -> substrateRegPhos
KS6B2_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANKS6B2_HUMANkinase -> substrateRobert H Newman (2013)
KS6B2_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
KS6B2_HUMANHSPB1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANKS6B2_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANKS6B2_HUMANkinase -> substrateRobert H Newman (2013)
KS6B2_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKS6B2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANKS6B2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04012ErbB signaling pathway
hsa04350TGF-beta signaling pathway
hsa05221Acute myeloid leukemia

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0006412translationTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0042277peptide bindingIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0045948positive regulation of translational initiationIMPbiological_process
GO:0004711ribosomal protein S6 kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function


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