Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARBK1_HUMAN
Description:adrenergic, beta, receptor kinase 1 [Source:HGNC Symbol;Acc:289]
Location:chr11 q13.2
Node attribute:kinase; effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y356VGTHGyMAPEVPkinasePhosphoSitePlus
Y206GFGEVyGCRKAPkinasePhosphoSitePlus
Y92EEIKKyEKLETRGSPhosphoSitePlus
S350KKPHAsVGTHGPkinasePhosphoSitePlus
S685LVQRGsANGLPKACaRegPhos
S685LVQRGsANGLPKA_groupRegPhos
S670KNKPRsPVVELPhosphoSitePlus; phosphoELM; SysPTM
S685LVQRGsANGL_PhosphoSitePlus
S685LVQRGsANPRKACAHPRD
S29PAARAsKKILLPKCgRegPhos
S29PAARAsKKILLPKCdRegPhos
S29PAARAsKKILLPKCaRegPhos
S670KNKPRsPVVELMAPK_groupphosphoELM; RegPhos; SysPTM
T248LSLVStGDCPFPkinasePhosphoSitePlus
S416VELPDsFSPELPkinasePhosphoSitePlus
T353HASVGtHGYMAPkinasePhosphoSitePlus
S29PAARAsKKILLPKC_alphaphosphoELM
S670KNKPRsPVVELErk1RegPhos; SysPTM
T263SYAFHtPDKLSPkinasePhosphoSitePlus
S685LVQRGsANPKA_groupphosphoELM
S29PAARAsKKILLPhosphoSitePlus
S670KNKPRsPVVELMAPK3HPRD; SysPTM
S29PAARAsKKILLPKCa(PKC alphaRegPhos
S247MLSLVsTGDCPPkinasePhosphoSitePlus
S29PAARAsKKILLPRKCGHPRD
S29PAARAsKKILLPRKCDHPRD
S29PAARAsKKILLPRKCAHPRD
Y506SDQELyRNFPLPhosphoSitePlus
T54DRGEVtFEKIFRGSPhosphoSitePlus
Y86PLVEFyEEIKKRGSPhosphoSitePlus
Y13LADVSyLMAMEPhosphoSitePlus

Dephosphorylation site
ARBK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312262M229VBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000312262R578QGreenman2007Intestines Cancer17344846, 18428421
ENSP00000312262R578QHPIColorectal Cancer17344846

Differential expressed protein
ARBK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ARBK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG12_HUMANARBK1_HUMANGprotein -> effectorgpDB
GNAQ_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBG5_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBG11_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBB5_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBG3_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBB1_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBB2_HUMANARBK1_HUMANGprotein -> effectorgpDB
GNA11_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBG1_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBG13_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBG2_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBG8_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBB3_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBG10_HUMANARBK1_HUMANGprotein -> effectorgpDB
ARBK1_HUMANPQBP1_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANOPRM_HUMANkinase -> substrateHPRD
ARBK1_HUMANSNF8_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANADRB2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCA_HUMANARBK1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ARBK1_HUMANOPRD_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ARBK1_HUMANSYUB_HUMANkinase -> substrateRegPhos
MK03_HUMANARBK1_HUMANkinase -> substrateHPRD
ARBK1_HUMANPGFRB_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ARBK1_HUMANHRH1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ARBK1_HUMANTBB3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ARBK1_HUMANSYUG_HUMANkinase -> substrateRegPhos
ARBK1_HUMANCNRG_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ARBK1_HUMANBKRB2_HUMANkinase -> substrateRegPhos
KPCG_HUMANARBK1_HUMANkinase -> substrateHPRD
ARBK1_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ARBK1_HUMANZN396_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANID2_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANRLA2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK11_HUMANARBK1_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANP53_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANADA2A_HUMANkinase -> substrateRegPhos
ARBK1_HUMANMC4R_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ARBK1_HUMANEZRI_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ARBK1_HUMANFPR1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ARBK1_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANARBK1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa05032Morphine addiction
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003108negative regulation of the force of heart contractIMPbiological_process
GO:0007217tachykinin receptor signaling pathwayIDAbiological_process
GO:0031623receptor internalizationIDAbiological_process
GO:0060048cardiac muscle contractionIMPbiological_process
GO:0031755Edg-2 lysophosphatidic acid receptor bindingIDAmolecular_function
GO:0004703G-protein coupled receptor kinase activityIEAmolecular_function
GO:0031694alpha-2A adrenergic receptor bindingISSmolecular_function
GO:0047696beta-adrenergic receptor kinase activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0033605positive regulation of catecholamine secretionISSbiological_process
GO:0002026regulation of the force of heart contractionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0045988negative regulation of striated muscle contractionIMPbiological_process
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0004672protein kinase activityISSmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0002029desensitization of G-protein coupled receptor protISSbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004703G-protein coupled receptor kinase activityISSmolecular_function
GO:0016020membraneISScellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0002029desensitization of G-protein coupled receptor protIEAbiological_process
GO:0018105peptidyl-serine phosphorylationISSbiological_process
GO:0007165signal transductionTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0007213G-protein coupled acetylcholine receptor signalingISSbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process