Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PP2AA_HUMAN
Description:protein phosphatase 2, catalytic subunit, alpha isozyme [Source:HGNC Symbol;Acc:9299]
Location:chr5 q31.1
Node attribute:phosphotase; substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y248LVMEGyNWCHDPhosphoSitePlus
T304HVTRRtPDYFLPhosphoSitePlus
Y91YVDRGyYSVETMetallophosPhosphoSitePlus
Y86LFMGDyVDRGYMetallophosPhosphoSitePlus
Y307RRTPDyFL___PhosphoSitePlus
Y92VDRGYySVETVMetallophosPhosphoSitePlus
Y265FSAPNyCYRCGPhosphoSitePlus
Y307RRTPDyphosphoELM
T304HVTRRtPDYphosphoELM
Y284DDTLKySFLQFPhosphoSitePlus

Dephosphorylation site
PP2AA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000418447Y130CCOSMICLung Cancer20668451
ENSP00000418447R49*COSMICOvarian Cancer21720365
ENSP00000418447R214*COSMICMelanoma21499247
ENSP00000418447R121TCOSMICOvarian Cancer21720365
ENSP00000418447*310SCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000418447Breast CancerNormal vs. CancertissueUp0.4620739354

Hyperphosphorylation site
PP2AA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SG494_HUMANPP2AA_HUMANkinase -> substrateRobert H Newman (2013)
CDK3_HUMANPP2AA_HUMANkinase -> substrateRobert H Newman (2013)
PP2AA_HUMANEF2_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANPACS1_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANAKT1_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANTAU_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANOPSD_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANRGAP1_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANIGSF5_HUMANphosphatase -> substrateKEGG
PP2AA_HUMANAXIN1_HUMANphosphatase -> substrateNetPath
PP2AA_HUMANKPCI_HUMANphosphatase -> substrateKEGG
PP2AA_HUMANKS6B1_HUMANphosphatase -> substrateKEGG
PP2AA_HUMANKPCD_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANGOGA2_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANTF65_HUMANphosphatase -> substrateNetPath
PP2AA_HUMANPYR1_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANDCE1_HUMANphosphatase -> substrateHPRD
TGFR2_HUMANPP2AA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04728Dopaminergic synapse
hsa04114Oocyte meiosis
hsa03015mRNA surveillance pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04730Long-term depression
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa05160Hepatitis C
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030111regulation of Wnt receptor signaling pathwayNASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0000188inactivation of MAPK activityNASbiological_process
GO:0005739mitochondrionNAScellular_component
GO:0006275regulation of DNA replicationNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0016020membraneNAScellular_component
GO:0000184nuclear-transcribed mRNA catabolic process, nonsenTASbiological_process
GO:0042518negative regulation of tyrosine phosphorylation ofNASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0040008regulation of growthNASbiological_process
GO:0030308negative regulation of cell growthNASbiological_process
GO:0007126meiosisIEAbiological_process
GO:0010719negative regulation of epithelial to mesenchymal tIMPbiological_process
GO:0000922spindle poleIEAcellular_component
GO:0000159protein phosphatase type 2A complexIEAcellular_component
GO:0045595regulation of cell differentiationNASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0046983protein dimerization activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0010469regulation of receptor activityIEAbiological_process
GO:0019932second-messenger-mediated signalingNASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0005634nucleusNAScellular_component
GO:0010033response to organic substanceNASbiological_process
GO:0030155regulation of cell adhesionNASbiological_process
GO:0008380RNA splicingNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031952regulation of protein autophosphorylationIEAbiological_process
GO:0006672ceramide metabolic processNASbiological_process
GO:0042176regulation of protein catabolic processIEAbiological_process
GO:0071902positive regulation of protein serine/threonine kiIMPbiological_process
GO:0006917induction of apoptosisTASbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0070208protein heterotrimerizationIEAbiological_process
GO:0015630microtubule cytoskeletonNAScellular_component
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0007498mesoderm developmentIEAbiological_process