| UniProt/SwissProt ID: | KKCC1_HUMAN |
| Description: | calcium/calmodulin-dependent protein kinase kinase 1, alpha [Source:HGNC Symbol;Acc:1469] |
| Location: | chr17 p13.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S452 | VILVKsMLRKR | PhosphoSitePlus | |
| S475 | EERSMsAPGNL | PhosphoSitePlus; HPRD | |
| S69 | ARPSLsARKLS | PhosphoSitePlus | |
| S458 | MLRKRsFGNPF | PhosphoSitePlus; HPRD; SysPTM | |
| S52 | RARAAsVIPGS | PhosphoSitePlus | |
| S513 | EERSMsAPGNL | HPRD | |
| S443 | VRLIPsWTTVI | PhosphoSitePlus | |
| S496 | MLRKRsFGNPF | HPRD | |
| S492 | GEGGKsPELPG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T108 | AWRRPtIESHH | PhosphoSitePlus; HPRD | |
| T446 | IPSWTtVILVK | PhosphoSitePlus | |
| S100 | PASHIsPRAWR | PhosphoSitePlus; HPRD | |
| S74 | SARKLsLQERP | PhosphoSitePlus; HPRD; SysPTM | |
| S97 | ATGPAsHISPR | HPRD | |
| T108 | AWRRPtIESHH | PKA_group | phosphoELM |
| Dephosphorylation site |
| KKCC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000158166 | P445L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000323118 | P407L | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| KKCC1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KKCC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | PHS_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKB_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | ASAP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | SRXN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK11_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | PAIRB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KCC2G_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK6_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | PRS6A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | CSDC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | CHSP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K8_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | CLK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | SMPX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DCLK1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | PSA6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | FHL2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | PSPC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | CP250_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DDR1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | AKT1_HUMAN | kinase -> substrate | HPRD |
| TGFR2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | PPP5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PINK1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K11_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PRP4B_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | BCL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A5_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | HDAC7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CSK22_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | IRF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | KCC1D_HUMAN | kinase -> substrate | HPRD |
| DYRK2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ACK1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | KCC4_HUMAN | kinase -> substrate | HPRD |
| KKCC1_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK7_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PI3R4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | PP1R8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NRBP2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | NDF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AAPK2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05034 | Alcoholism |
| hsa04920 | Adipocytokine signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004683 | calmodulin-dependent protein kinase activity | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |