Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PPM1A_HUMAN
Description:protein phosphatase, Mg2+/Mn2+ dependent, 1A [Source:HGNC Symbol;Acc:9275]
Location:chr14 q23.1
Node attribute:phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y362VIEAVyNRLNPPP2C_CPhosphoSitePlus
S285SRDNMsVILICPP2C_CPhosphoSitePlus
S375NDDTDsTSTDDPhosphoSitePlus
S377DTDSTsTDDMWPhosphoSitePlus
Y311AELDKyLECRVPP2C_CPhosphoSitePlus
T373YKNDDtDSTSTPhosphoSitePlus

Dephosphorylation site
PPM1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378514P92LCOSMICMelanoma21499247
ENSP00000432966P92LCOSMICMelanoma21499247

Differential expressed protein
PPM1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PPM1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PPM1A_HUMANMOES_HUMANphosphatase -> substrateHPRD
PPM1A_HUMANP85A_HUMANphosphatase -> substrateHPRD
PPM1A_HUMANMP2K3_HUMANphosphatase -> substrateKEGG
PPM1A_HUMANGRM3_HUMANphosphatase -> substrateHPRD
PPM1A_HUMANMP2K6_HUMANphosphatase -> substrateKEGG
PPM1A_HUMANMP2K4_HUMANphosphatase -> substrateKEGG
PPM1A_HUMANKPCD_HUMANphosphatase -> substrateHPRD
PPM1A_HUMANMP2K7_HUMANphosphatase -> substrateKEGG
PPM1A_HUMANEF2_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010467gene expressionTASbiological_process
GO:0035970peptidyl-threonine dephosphorylationIDAbiological_process
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0016311dephosphorylationIDAbiological_process
GO:0030145manganese ion bindingIEAmolecular_function
GO:0030512negative regulation of transforming growth factor IDAbiological_process
GO:0033192calmodulin-dependent protein phosphatase activityIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0016055Wnt receptor signaling pathwayIDAbiological_process
GO:0010991negative regulation of SMAD protein complex assembIDAbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0070412R-SMAD bindingIPImolecular_function
GO:0005891voltage-gated calcium channel complexIEAcellular_component
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0004871signal transducer activityIMPmolecular_function
GO:0003824catalytic activityIEAmolecular_function
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0030177positive regulation of Wnt receptor signaling pathIDAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function


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