Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:4ET_HUMAN
Description:eukaryotic translation initiation factor 4E nuclear import factor 1 [Source:HGNC Symbol;Acc:16687]
Location:chr22 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S77PASGRsSPVESHPRD
S768QRSSCsTPLSQPhosphoSitePlus
S920HAAAVsVQTTPPhosphoSitePlus; HPRD; phosphoELM
S681RGNSSsPAPAAEIF4E-TPhosphoSitePlus
S138SRRSGsPLEKDHPRD; phosphoELM
S379SPGQNsGNYFAEIF4E-TPhosphoSitePlus
Y382QNSGNyFAPIPEIF4E-TPhosphoSitePlus
S568PSPPLsQVFQTHPRD
S301VLPEQsPGDFDHPRD
T482KDGDMtAFNKLHPRD
S914PPGSGsHAAAVPhosphoSitePlus; HPRD; phosphoELM
S417LLSSLsANKEKEIF4E-TPhosphoSitePlus
S587RPRIPsPIGFTHPRD; SysPTM
S797TPTLAsPVPTTPhosphoSitePlus
T924VSVQTtPQNVPPhosphoSitePlus
S414LKPLLsSLSANHPRD
S259RRRTAsVKEGIEIF4E-TPhosphoSitePlus
S69EKWHAsLYPASHPRD
T801ASPVPtTPFLRPhosphoSitePlus
Y214RRNDSyTEEEPEIF4E-TPhosphoSitePlus
S74SLYPAsGRSSPEIF4E-TPhosphoSitePlus
S77PASGRsSPVESEIF4E-TPhosphoSitePlus
S513ESHLMsPAEIPEIF4E-TPhosphoSitePlus
S120SPQRRsFGGGCEIF4E-TPhosphoSitePlus; SysPTM
S356SSSLGsTPHEEEIF4E-TPhosphoSitePlus
S345WFSNPsRSGSREIF4E-TPhosphoSitePlus; SysPTM
Y580AASADyLRPRIEIF4E-TPhosphoSitePlus
T215RNDSYtEEEPEEIF4E-TPhosphoSitePlus
T455QVKNStPFMAEEIF4E-TPhosphoSitePlus
T227FSAGPtSQSETEIF4E-TPhosphoSitePlus
S541QRPASsNLLSGEIF4E-TPhosphoSitePlus
S374EQAILsPGQNSHPRD
S5GETEHPRD; phosphoELM
S301VLPEQsPGDFDEIF4E-TPhosphoSitePlus
S82SSPVEsLKKELEIF4E-TPhosphoSitePlus
S467LEETLsAVTNNEIF4E-TPhosphoSitePlus
T496MKASGtLPSQPHPRD
Y983VDELEyRQ___PhosphoSitePlus
S564GQRAPsPPLSQEIF4E-TPhosphoSitePlus; SysPTM
T253KGRKRtRRRTAEIF4E-TPhosphoSitePlus
S577QTRAAsADYLREIF4E-TPhosphoSitePlus
S752ADRDSsPTTNSPhosphoSitePlus
S78ASGRSsPVESLHPRD
S670QRVTKsPAPVHHPRD
S618ITAQMsQLELQEIF4E-TPhosphoSitePlus
S568PSPPLsQVFQTEIF4E-TPhosphoSitePlus
S946LEHRPsQRSSSPhosphoSitePlus
S138SRRSGsPLEKDEIF4E-TPhosphoSitePlus
T592SPIGFtPGPQQEIF4E-TPhosphoSitePlus
S611MRKPMsPITAQEIF4E-TPhosphoSitePlus
S587RPRIPsPIGFTEIF4E-TPhosphoSitePlus; SysPTM
S223EPEWFsAGPTSEIF4E-TPhosphoSitePlus
S693ITSMLsPSFTPHPRD; phosphoELM
S494STMKAsGTLPSHPRD
S417LLSSLsANKEKHPRD
S513ESHLMsPAEIPHPRD; phosphoELM
S78ASGRSsPVESLEIF4E-TPhosphoSitePlus
T769RSSCStPLSQAPhosphoSitePlus; SysPTM
T465EHLEEtLSAVTEIF4E-TPhosphoSitePlus
S120SPQRRsFGGGCHPRD; phosphoELM; SysPTM
T257RTRRRtASVKEEIF4E-TPhosphoSitePlus
T614PMSPItAQMSQEIF4E-TPhosphoSitePlus
S136VSSRRsGSPLEEIF4E-TPhosphoSitePlus
S353GSRSSsLGSTPEIF4E-TPhosphoSitePlus
S374EQAILsPGQNSEIF4E-TPhosphoSitePlus
S213RRRNDsYTEEEEIF4E-TPhosphoSitePlus
S680HRGNSsSPAPAHPRD; phosphoELM
S564GQRAPsPPLSQHPRD; phosphoELM; SysPTM
S757SPTTNsKLSALHPRD; phosphoELM
S693ITSMLsPSFTPEIF4E-TPhosphoSitePlus
S680HRGNSsSPAPAEIF4E-TPhosphoSitePlus
Y71WHASLyPASGREIF4E-TPhosphoSitePlus
S136VSSRRsGSPLEHPRD; phosphoELM
S454QQVKNsTPFMAEIF4E-TPhosphoSitePlus
S951SQRSSsPVGLAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S670QRVTKsPAPVHEIF4E-TPhosphoSitePlus
T357SSLGStPHEELEIF4E-TPhosphoSitePlus
S772CSTPLsQANRYPhosphoSitePlus
S345WFSNPsRSGSRHPRD; phosphoELM; SysPTM
S342FSRWFsNPSRSEIF4E-TPhosphoSitePlus
S5_MDRRsMGETEPhosphoSitePlus
S74SLYPAsGRSSPHPRD; phosphoELM
S321VPCLAsMIEDVEIF4E-TPhosphoSitePlus

Dephosphorylation site
4ET_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380659G890fs*89COSMICOvarian Cancer21720365
ENSP00000380659R944CCOSMICOvarian Cancer21720365
ENSP00000380659F15CCOSMICSkin Cancer21984974
ENSP00000380659E363QCOSMICHead and Neck Cancer21798893

Differential expressed protein
4ET_HUMAN is not differential expressed protein.

Hyperphosphorylation site
4ET_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK2_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
4ET_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0003743translation initiation factor activityIEAmolecular_function
GO:0008565protein transporter activityTASmolecular_function
GO:0016605PML bodyIEAcellular_component
GO:0016607nuclear speckIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolIEAcellular_component
GO:0005737cytoplasmTAScellular_component


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