Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FSCN1_HUMAN
Description:fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) [Source:HGNC Symbol;Acc:11148]
Location:chr7 p22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T484KASAEtVDPASFascinPhosphoSitePlus
Y145PQVNIySVTRKFascinPhosphoSitePlus
S39NASASsLKKKQPKC_groupphosphoELM; RegPhos
T148NIYSVtRKRYAFascinPhosphoSitePlus
S120TEDRLsCFAQTFascinPhosphoSitePlus
S39NASASsLKKKQPKCdRegPhos
Y23NCGNKyLTAEAFascinPhosphoSitePlus
S39NASASsLKKKQPRKCDHPRD
S39NASASsLKKKQphosphoELM
S38VNASAsSLKKKHPRD; phosphoELM; SysPTM
S39NASASsLKKKQFascinPhosphoSitePlus
Y314THTGKyWTLTAFascinPhosphoSitePlus
S38VNASAsSLKKKFascinPhosphoSitePlus; SysPTM
T239SGPSGtLKAGKFascinPhosphoSitePlus

Dephosphorylation site
FSCN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000371798V323MCOSMICHead and Neck Cancer21798893

Differential expressed protein
FSCN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S39FascinKVNASASsLKKKQIWcancer, squamous cell carcinoma20713986PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANFSCN1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
FSCN1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030175filopodiumIEAcellular_component
GO:0030036actin cytoskeleton organizationIDAbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0051017actin filament bundle assemblyIEAbiological_process
GO:0071437invadopodiumIDAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0001725stress fiberIDAcellular_component
GO:0016477cell migrationIEAbiological_process
GO:0030674protein binding, bridgingIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0048870cell motilityIDAbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0051015actin filament bindingIEAmolecular_function
GO:0003779actin bindingIDAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0015629actin cytoskeletonIDAcellular_component
GO:0005515protein bindingIPImolecular_function


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