| UniProt/SwissProt ID: | TRIB3_HUMAN |
| Description: | tribbles homolog 3 (Drosophila) [Source:HGNC Symbol;Acc:16228] |
| Location: | chr20 p13 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T64 | ATAVAtASRLG | PhosphoSitePlus | |
| Dephosphorylation site |
| TRIB3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000217233 | T60I | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000217233 | T60I | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 |
| Differential expressed protein |
| TRIB3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TRIB3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TRIB3_HUMAN | TSNAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | MTG8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | ZN692_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | KPCD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | ZN502_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | BCL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | EP400_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | ZN319_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | LUZP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | PBX2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | 2AAB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | CSN6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | NDF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | LDOC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | UHMK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TRIB3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0048015 | phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0010827 | regulation of glucose transport | IEA | biological_process |
| GO:0043405 | regulation of MAP kinase activity | IDA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0044255 | cellular lipid metabolic process | TAS | biological_process |
| GO:0055106 | ubiquitin-protein ligase regulator activity | IEA | molecular_function |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0045717 | negative regulation of fatty acid biosynthetic pro | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0070059 | intrinsic apoptotic signaling pathway in response | IDA | biological_process |
| GO:0019899 | enzyme binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006469 | negative regulation of protein kinase activity | IEA | biological_process |
| GO:0004860 | protein kinase inhibitor activity | IEA | molecular_function |
| GO:0003714 | transcription corepressor activity | IEA | molecular_function |
| GO:0034976 | response to endoplasmic reticulum stress | IDA | biological_process |
| GO:0051443 | positive regulation of ubiquitin-protein ligase ac | IEA | biological_process |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0031625 | ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0032869 | cellular response to insulin stimulus | IEA | biological_process |
| GO:0045599 | negative regulation of fat cell differentiation | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0032092 | positive regulation of protein binding | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0019901 | protein kinase binding | ISS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |