Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KCC2D_HUMAN
Description:calcium/calmodulin-dependent protein kinase II delta [Source:HGNC Symbol;Acc:1462]
Location:chr4 q26
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T331GVKEStESSNTCAMK2DHPRD; SysPTM
S3___MAsTTTCTPhosphoSitePlus; SysPTM
S472FHRSGsPTVPHPRD; SysPTM
T254INKMLtINPAKPkinase_CAMKPhosphoSitePlus
S404FENALsKSNKPCaMKII_ADPhosphoSitePlus
T311TTMLAtRNFSAPhosphoSitePlus
S319FSAAKsLLKKPPhosphoSitePlus; phosphoELM; SysPTM
S315ATRNFsAAKSLCAMK2DHPRD
T337ESSNTtIEDEDPhosphoSitePlus; phosphoELM
S441QYMDGsGMPKTCaMKII_ADPhosphoSitePlus
S333KESTEsSNTTICAMK2DHPRD
S280RSTVAsMMHRQPhosphoSitePlus
S490GKENFsGGTSLPhosphoSitePlus
S3TTCTHPRD; SysPTM
S276WICQRsTVASMPhosphoSitePlus
T307GAILTtMLATRPhosphoSitePlus
T337ESSNTtIEDEDCAMK2DHPRD
S334ESTESsNTTIEPhosphoSitePlus
S315ATRNFsAAKSLPhosphoSitePlus; phosphoELM
S334ESTESsNTTIECAMK2DHPRD
T287MHRQEtVDCLKPhosphoSitePlus; HPRD
Y231IKAGAyDFPSPPkinase_CAMKPhosphoSitePlus
T306KGAILtTMLATPhosphoSitePlus
S319FSAAKsLLKKPCAMK2DHPRD; SysPTM
S235AYDFPsPEWDTPkinase_CAMKPhosphoSitePlus
S472FHRSGsPTVPICaMKII_ADPhosphoSitePlus; SysPTM
S472FHRSGsPTVPIHPRD; SysPTM
T331GVKEStESSNTPhosphoSitePlus; SysPTM
S333KESTEsSNTTIPhosphoSitePlus
S330DGVKEsTESSNPhosphoSitePlus; HPRD
T336TESSNtTIEDEPhosphoSitePlus; HPRD

Dephosphorylation site
KCC2D_HUMAN do not have dephosphorylation site.

Mutation site
KCC2D_HUMAN do not have mutation site.

Differential expressed protein
KCC2D_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KCC2D_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2D_HUMANKCC2D_HUMANkinase -> substrateHPRD
KCC2D_HUMANNR0B2_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANCREM_HUMANkinase -> substrateHPRD
KCC2D_HUMANVIME_HUMANkinase -> substrateHPRD
KCC2D_HUMANLIMA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis
hsa04912GnRH signaling pathway
hsa04310Wnt signaling pathway
hsa05214Glioma
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04012ErbB signaling pathway
hsa05152Tuberculosis
hsa04020Calcium signaling pathway
hsa04114Oocyte meiosis
hsa04728Dopaminergic synapse
hsa04720Long-term potentiation
hsa04971Gastric acid secretion
hsa05031Amphetamine addiction
hsa04740Olfactory transduction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0031594neuromuscular junctionIEAcellular_component
GO:0004683calmodulin-dependent protein kinase activityIEAmolecular_function
GO:0043194axon initial segmentIEAcellular_component
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005954calcium- and calmodulin-dependent protein kinase cTAScellular_component
GO:0033017sarcoplasmic reticulum membraneIEAcellular_component
GO:0030315T-tubuleIEAcellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0001558regulation of cell growthNASbiological_process
GO:0010613positive regulation of cardiac muscle hypertrophyIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046777protein autophosphorylationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0010881regulation of cardiac muscle contraction by regulaTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0060314regulation of ryanodine-sensitive calcium-release TASbiological_process
GO:0060341regulation of cellular localizationIMPbiological_process
GO:0005524ATP bindingNASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0060048cardiac muscle contractionIEAbiological_process
GO:0008016regulation of heart contractionTASbiological_process
GO:0014704intercalated discIEAcellular_component
GO:0006468protein phosphorylationNASbiological_process
GO:0005829cytosolTAScellular_component
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component


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