Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	LCK_HUMAN
Description:	lymphocyte-specific protein tyrosine kinase [Source:HGNC Symbol;Acc:6524]
Location:	chr1 p35.1
Node attribute:	kinase; substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y394	IEDNEyTAREG	LCK	HPRD; RegPhos
Y263	EVWMGyYNGHT	Pkinase_Tyr	PhosphoSitePlus
Y505	ATEGQyQPQP		RegPhos
S162	ESTAGsFSLSV		phosphoELM; RegPhos
S42	LIRNGsEVRDP	PKCa	RegPhos
Y394	IEDNEyTAREG	Pkinase_Tyr	PhosphoSitePlus
S102	WWKAQsLTTGQ	SH3_1	PhosphoSitePlus
Y505	ATEGQyQPQP	CSK	RegPhos
Y264	VWMGYyNGHTK	Pkinase_Tyr	PhosphoSitePlus
S59	SNPPAsPLQDN		PhosphoSitePlus; phosphoELM; RegPhos
S194	GGFYIsPRITF		phosphoELM; RegPhos
Y25	CENCHyPIVPL		PhosphoSitePlus
S59	SNPPAsPLQDN	Erk2	RegPhos
S42	LIRNGsEVRDP	Erk1(MAPK3	RegPhos
T50	RDPLVtYEGSN		PhosphoSitePlus
S42	LIRNGsEVRDP	PRKCA	HPRD
S59	SNPPAsPLQDN	Erk1	RegPhos
S42	LIRNGsEVRDP	Erk2(MAPK1	RegPhos
S158	IRESEsTAGSF	SH2	PhosphoSitePlus
S274	KVAVKsLKQGS	Pkinase_Tyr	PhosphoSitePlus
Y394	IEDNEyTAREG	Lck	phosphoELM; RegPhos
Y51	DPLVTyEGSNP		PhosphoSitePlus
S492	FDYLRsVLEDF	Pkinase_Tyr	PhosphoSitePlus
Y209	ELVRHyTNASD	SH2	PhosphoSitePlus
Y192	DNGGFyISPRI	SH2	PhosphoSitePlus
S42	LIRNGsEVRDP	PKACa	RegPhos
T35	LDGKGtLLIRN		PhosphoSitePlus
Y505	ATEGQyQP		HPRD; phosphoELM
Y505	ATEGQyQP	CSK	HPRD
S59	SNPPAsPLQDN	MAPK3	HPRD
S133	FFKNLsRKDAE		HPRD
S194	GGFYIsPRITF	SH2	PhosphoSitePlus
Y192	DNGGFyISPRI		HPRD; phosphoELM; RegPhos
Y414	PEAINyGTFTI	Pkinase_Tyr	PhosphoSitePlus
Y505	ATEGQyQP	Lck	phosphoELM
T210	LVRHYtNASDG		PhosphoSitePlus
S158	IRESEsTAGSF		phosphoELM; RegPhos
Y470	CPEELyQLMRL	Pkinase_Tyr	PhosphoSitePlus
Y394	IEDNEyTAREG	FCGR3A	HPRD
T395	EDNEYtAREGA	Pkinase_Tyr	PhosphoSitePlus
S156	FLIREsESTAG	SH2	PhosphoSitePlus
S162	ESTAGsFSLSV	SH2	PhosphoSitePlus
Y505	ATEGQyQPQP_		PhosphoSitePlus
Y394	IEDNEyTAREG	P08637(CD16	RegPhos
Y489	RPTFDyLRSVL	Pkinase_Tyr	PhosphoSitePlus
Y394	IEDNEyTAREG		HPRD; phosphoELM
T159	RESEStAGSFS	SH2	PhosphoSitePlus
T501	DFFTAtEGQYQ		PhosphoSitePlus; phosphoELM; RegPhos
S213	HYTNAsDGLCT		PhosphoSitePlus; phosphoELM; RegPhos
Y393	LIEDNeYTARE		HPRD
Y394	IEDNEyTAREG	autocatalysis	RegPhos
T416	AINYGtFTIKS	Pkinase_Tyr	PhosphoSitePlus
Y505	ATEGQyQPQP	Lck	RegPhos
T268	YYNGHtKVAVK	Pkinase_Tyr	PhosphoSitePlus
T375	ILVSDtLSCKI	Pkinase_Tyr	PhosphoSitePlus
S42	LIRNGsEVRDP	MAPK1	phosphoELM
S281	KQGSMsPDAFL	Pkinase_Tyr	PhosphoSitePlus
S42	LIRNGsEVRDP		PhosphoSitePlus
S59	SNPPAsPLQDN	MAPK1	HPRD
S42	LIRNGsEVRDP	MAPK3	phosphoELM
Y192	DNGGFyISPRI	SYK	HPRD; RegPhos
S42	LIRNGsEVRDP	PRKACA	HPRD
Y181	EVVKHyKIRNL	SH2	PhosphoSitePlus

Dephosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y505	FTATEGQyQPQP	PTPRC	HPRD
Y394	RLIEDNEyTAREGAK	PTPN6	HPRD
Y394	RLIEDNEyTAREGAK	PTPN22	HPRD
Y394	RLIEDNEyTAREGAK	PTPRC	HPRD

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000337825	P447L	HPI	Leukemia	8139546
ENSP00000337825	P331S	Ding2008	Lung Cancer	18948947
ENSP00000337825	A353V	HPI	Leukemia	8139546
ENSP00000337825	V28L	HPI	Leukemia	8139546

Differential expressed protein

LCK_HUMAN is not differential expressed protein.

Hyperphosphorylation site

LCK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
LCK_HUMAN	SPTN1_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
LCK_HUMAN	MUC1_HUMAN	kinase -> substrate	NetPath
LCK_HUMAN	CBL_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	ITK_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath; Robert H Newman (2013)
LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
LCK_HUMAN	NAR4_HUMAN	kinase -> substrate	HPRD; RegPhos
LCK_HUMAN	LIME1_HUMAN	kinase -> substrate	RegPhos; NetPath
LCK_HUMAN	SIG10_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	PLCG2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
LCK_HUMAN	KPCT_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
LCK_HUMAN	CD5_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
LCK_HUMAN	CD28_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	IRAK1_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	SHC1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
LCK_HUMAN	TRI16_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	VHL_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	LCP2_HUMAN	kinase -> substrate	RegPhos; NetPath
LCK_HUMAN	SMRC2_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	PTN6_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
LCK_HUMAN	VAV2_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	PPAC_HUMAN	kinase -> substrate	RegPhos
LCK_HUMAN	P85A_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
LCK_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
LCK_HUMAN	SIT1_HUMAN	kinase -> substrate	NetPath
LCK_HUMAN	VAV_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
LCK_HUMAN	SOCS3_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	LAX1_HUMAN	kinase -> substrate	NetPath
LCK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
LCK_HUMAN	ERF_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	MBNL3_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	ENC2_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	HNRPK_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	MTA1_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	KSYK_HUMAN	kinase -> substrate	NetPath
FCG3A_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD
LCK_HUMAN	EZRI_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
LCK_HUMAN	CIP4_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	PTEN_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	MAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
MK03_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
LCK_HUMAN	MED28_HUMAN	kinase -> substrate	HPRD
CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
LCK_HUMAN	SRC8_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	CD79B_HUMAN	kinase -> substrate	RegPhos; NetPath
LCK_HUMAN	CD3Z_HUMAN	kinase -> substrate	NetPath
KSYK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
LCK_HUMAN	SLAF1_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	DAPP1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
LCK_HUMAN	T22D3_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	PINX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	CTLA4_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
ZAGL2_HUMAN	LCK_HUMAN	kinase -> substrate	RegPhos
LCK_HUMAN	RFA2_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	DEFI6_HUMAN	kinase -> substrate	HPRD
LCK_HUMAN	WWP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	GAB2_HUMAN	kinase -> substrate	NetPath
LCK_HUMAN	IKBA_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
LCK_HUMAN	CD3E_HUMAN	kinase -> substrate	RegPhos
LCK_HUMAN	FGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	MK01_HUMAN	kinase -> substrate	NetPath
LCK_HUMAN	TRAT1_HUMAN	kinase -> substrate	NetPath
LCK_HUMAN	SH2B3_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath; Robert H Newman (2013)
KPCA_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD
LCK_HUMAN	CD33_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	MK12_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	HDAC8_HUMAN	kinase -> substrate	Robert H Newman (2013)
MK01_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
LCK_HUMAN	IL2RB_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
LCK_HUMAN	RASA1_HUMAN	kinase -> substrate	HPRD; RegPhos
LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	CD79A_HUMAN	kinase -> substrate	NetPath
PTPRH_HUMAN	LCK_HUMAN	phosphatase -> substrate	NetPath
PTN22_HUMAN	LCK_HUMAN	phosphatase -> substrate	HPRD
PTN6_HUMAN	LCK_HUMAN	phosphatase -> substrate	HPRD
PTPRC_HUMAN	LCK_HUMAN	phosphatase -> substrate	HPRD; KEGG

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05340	Primary immunodeficiency
hsa05166	HTLV-I infection
hsa04650	Natural killer cell mediated cytotoxicity
hsa04064	NF-kappa B signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04380	Osteoclast differentiation

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0042610	CD8 receptor binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0051209	release of sequestered calcium ion into cytosol	IEA	biological_process
GO:0030097	hemopoiesis	NAS	biological_process
GO:0042493	response to drug	ISS	biological_process
GO:0006882	cellular zinc ion homeostasis	ISS	biological_process
GO:0043548	phosphatidylinositol 3-kinase binding	IPI	molecular_function
GO:0042609	CD4 receptor binding	IPI	molecular_function
GO:0010628	positive regulation of gene expression	IEA	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0006919	activation of cysteine-type endopeptidase activity	ISS	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0018108	peptidyl-tyrosine phosphorylation	IEA	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0070474	positive regulation of uterine smooth muscle contr	IEA	biological_process
GO:0006917	induction of apoptosis	ISS	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0051249	regulation of lymphocyte activation	NAS	biological_process
GO:0050862	positive regulation of T cell receptor signaling p	NAS	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0003823	antigen binding	IEA	molecular_function
GO:0000242	pericentriolar material	ISS	cellular_component
GO:0016032	viral reproduction	TAS	biological_process
GO:0007596	blood coagulation	TAS	biological_process
GO:0008022	protein C-terminus binding	IPI	molecular_function
GO:0005515	protein binding	IEA	molecular_function
GO:0010038	response to metal ion	IEA	biological_process
GO:0007568	aging	IEA	biological_process
GO:0030217	T cell differentiation	ISS	biological_process
GO:0005524	ATP binding	IEA	molecular_function
GO:0050856	regulation of T cell receptor signaling pathway	IEA	biological_process
GO:0050870	positive regulation of T cell activation	ISS	biological_process
GO:0042169	SH2 domain binding	ISS	molecular_function
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0030139	endocytic vesicle	IEA	cellular_component
GO:0042523	positive regulation of tyrosine phosphorylation of	IEA	biological_process
GO:0032403	protein complex binding	IEA	molecular_function
GO:0005886	plasma membrane	IEA	cellular_component
GO:0004722	protein serine/threonine phosphatase activity	ISS	molecular_function
GO:0019048	virus-host interaction	IEA	biological_process
GO:0042542	response to hydrogen peroxide	IEA	biological_process
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0001948	glycoprotein binding	IPI	molecular_function
GO:0031295	T cell costimulation	TAS	biological_process
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0001772	immunological synapse	IDA	cellular_component
GO:0050690	regulation of defense response to virus by virus	TAS	biological_process
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0009612	response to mechanical stimulus	IEA	biological_process
GO:0045588	positive regulation of gamma-delta T cell differen	IEA	biological_process
GO:0046777	protein autophosphorylation	IEA	biological_process
GO:0019901	protein kinase binding	IPI	molecular_function
GO:0006915	apoptotic process	IEA	biological_process
GO:0051117	ATPase binding	IPI	molecular_function
GO:0010043	response to zinc ion	IEA	biological_process
GO:0045121	membrane raft	IEA	cellular_component
GO:0050853	B cell receptor signaling pathway	IEA	biological_process
GO:0007166	cell surface receptor signaling pathway	IEA	biological_process
GO:0004715	non-membrane spanning protein tyrosine kinase acti	IEA	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network