Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BMR1A_HUMAN
Description:bone morphogenetic protein receptor, type IA [Source:HGNC Symbol;Acc:1076]
Location:chr10 q23.2
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S215IDQSQsSGSGSHPRD
S216DQSQSsGSGSGHPRD
S218SQSSGsGSGLPHPRD
S220SSGSGsGLPLLHPRD

Dephosphorylation site
BMR1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361107F58YGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000224764T520MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000224764F58YGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000224764R486QGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000361107W487*Greenman2007Intestines Cancer17344846, 18428421
ENSP00000361107T520MDing2008Lung Cancer18948947
ENSP00000224764W487*Greenman2007Intestines Cancer17344846, 18428421
ENSP00000224764E104KCOSMICOvarian Cancer21720365
ENSP00000361107R486QGreenman2007, HPIGastric Cancer17344846, 18428421

Differential expressed protein
BMR1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BMR1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BMP2_HUMANBMR1A_HUMANligand -> receptorHPMR
BMP7_HUMANBMR1A_HUMANligand -> receptorHPMR
BMP4_HUMANBMR1A_HUMANligand -> receptorHPMR
BMP6_HUMANBMR1A_HUMANligand -> receptorHPMR
BMR1A_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANSMAD1_HUMANkinase -> substrateKEGG
BMR1A_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANIF2A_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030154cell differentiationIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0003272endocardial cushion formationISSbiological_process
GO:0060896neural plate pattern specificationIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0060391positive regulation of SMAD protein import into nuIDAbiological_process
GO:0048598embryonic morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0048378regulation of lateral mesodermal cell fate specifiIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0060021palate developmentIEAbiological_process
GO:0030501positive regulation of bone mineralizationIMPbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0060914heart formationIEAbiological_process
GO:0021983pituitary gland developmentIEAbiological_process
GO:0048368lateral mesoderm developmentIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0001756somitogenesisIEAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0007492endoderm developmentIEAbiological_process
GO:0014032neural crest cell developmentIEAbiological_process
GO:0006955immune responseIMPbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0048352paraxial mesoderm structural organizationIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0035137hindlimb morphogenesisIEAbiological_process
GO:0003272endocardial cushion formationIEAbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0019827stem cell maintenanceIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0048339paraxial mesoderm developmentIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0048568embryonic organ developmentIEAbiological_process
GO:0001880Mullerian duct regressionIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0021998neural plate mediolateral regionalizationIEAbiological_process
GO:0007398ectoderm developmentIEAbiological_process
GO:0004675transmembrane receptor protein serine/threonine kiTASmolecular_function
GO:0009950dorsal/ventral axis specificationIEAbiological_process
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0005901caveolaIMPcellular_component
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0003007heart morphogenesisIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0051216cartilage developmentIEAbiological_process
GO:0048382mesendoderm developmentIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0001707mesoderm formationIEAbiological_process
GO:0050768negative regulation of neurogenesisIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process