Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLS1_HUMAN
Description:phospholipid scramblase 1 [Source:HGNC Symbol;Acc:9092]
Location:chr3 q24
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T161PSRPFtLRIIDScramblasePhosphoSitePlus
T161PSRPFtLRIIDPRKCDHPRD
T161PSRPFtLRIIDPKCdRegPhos
Y69PNQPVyNQPVYABL1HPRD; RegPhos
Y69PNQPVyNQPVYSRCphosphoELM
Y74YNQPVyNQPVGSRCphosphoELM
Y74YNQPVyNQPVGAblphosphoELM
Y74YNQPVyNQPVGSrcRegPhos
Y69PNQPVyNQPVYPhosphoSitePlus
Y69PNQPVyNQPVYSrcRegPhos
Y74YNQPVyNQPVGABL1HPRD; RegPhos
Y74YNQPVyNQPVGPhosphoSitePlus
T161PSRPFtLRIIDPKC_groupRegPhos
Y69PNQPVyNQPVYAblphosphoELM

Dephosphorylation site
PLS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000345494S103GCOSMICSkin Cancer21984974
ENSP00000345494A88VCOSMICOvarian Cancer21720365
ENSP00000345494D301HCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000345494Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
PLS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ABL1_HUMANPLS1_HUMANkinase -> substrateRegPhos
KPCD_HUMANPLS1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
PLS1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIDAcellular_component
GO:0045089positive regulation of innate immune responseIMPbiological_process
GO:0035456response to interferon-betaIMPbiological_process
GO:0006953acute-phase responseISSbiological_process
GO:0017128phospholipid scramblase activityIDAmolecular_function
GO:0033003regulation of mast cell activationISSbiological_process
GO:0017121phospholipid scramblingIDAbiological_process
GO:0051607defense response to virusIMPbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:2000373positive regulation of DNA topoisomerase (ATP-hydrIDAbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0006659phosphatidylserine biosynthetic processISSbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0006915apoptotic processIDAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0005509calcium ion bindingIDAmolecular_function
GO:0005154epidermal growth factor receptor bindingIPImolecular_function
GO:0030168platelet activationNASbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0060368regulation of Fc receptor mediated stimulatory sigISSbiological_process
GO:0045071negative regulation of viral genome replicationIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045121membrane raftIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005887integral to plasma membraneIDAcellular_component
GO:0042609CD4 receptor bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0001077RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0019899enzyme bindingIPImolecular_function


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