Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TWST1_HUMAN
Description:twist basic helix-loop-helix transcription factor 1 [Source:HGNC Symbol;Acc:12428]
Location:chr7 p21.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S123RQRTQsLNEAFToxin_trans; HLHPhosphoSitePlus
S102GGSPQsYEELQToxin_transPhosphoSitePlus
Y103GSPQSyEELQTToxin_transPhosphoSitePlus
T137RKIIPtLPSDKToxin_trans; HLHPhosphoSitePlus
S68GDEPGsPAQGKPhosphoSitePlus
S42RKRRSsRRSAGPhosphoSitePlus
S18ADDSLsNSEEEPhosphoSitePlus
S20DSLSNsEEEPDPhosphoSitePlus

Dephosphorylation site
TWST1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000242261E181*COSMICHead and Neck Cancer21798893
ENSP00000242261*203LCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
TWST1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S68GGGDEPGsPAQGKRGbreast cancer21502402PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANTWST1_HUMANkinase -> substrateRobert H Newman (2013)
TWST1_HUMANGLI1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TWST1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:2000773negative regulation of cellular senescenceIMPbiological_process
GO:0003253cardiac neural crest cell migration involved in ouIEAbiological_process
GO:0003180aortic valve morphogenesisIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:2000679positive regulation of transcription regulatory reIMPbiological_process
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:2000778positive regulation of interleukin-6 secretionIMPbiological_process
GO:0048642negative regulation of skeletal muscle tissue deveIEAbiological_process
GO:2000147positive regulation of cell motilityIEAbiological_process
GO:2000147positive regulation of cell motilityNASbiological_process
GO:0045766positive regulation of angiogenesisNASbiological_process
GO:0048704embryonic skeletal system morphogenesisIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0061029eyelid development in camera-type eyeIMPbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0001503ossificationTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0071639positive regulation of monocyte chemotactic proteiIMPbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:2000780negative regulation of double-strand break repairIMPbiological_process
GO:0003183mitral valve morphogenesisIEAbiological_process
GO:0060363cranial suture morphogenesisIEAbiological_process
GO:0042473outer ear morphogenesisTASbiological_process
GO:0032760positive regulation of tumor necrosis factor produIMPbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIDAmolecular_function
GO:0035359negative regulation of peroxisome proliferator actIEAbiological_process
GO:0044092negative regulation of molecular functionIEAbiological_process
GO:0035137hindlimb morphogenesisIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0003180aortic valve morphogenesisIEAbiological_process
GO:0042733embryonic digit morphogenesisTASbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIMPbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0035116embryonic hindlimb morphogenesisIEAbiological_process
GO:0001503ossificationIEAbiological_process
GO:0043425bHLH transcription factor bindingIPImolecular_function
GO:0003203endocardial cushion morphogenesisIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0045668negative regulation of osteoblast differentiationIMPbiological_process
GO:0014067negative regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0035115embryonic forelimb morphogenesisIEAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0060363cranial suture morphogenesisTASbiological_process
GO:0030500regulation of bone mineralizationIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0010718positive regulation of epithelial to mesenchymal tIEAbiological_process
GO:2000793cell proliferation involved in heart valve developIMPbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0032000positive regulation of fatty acid beta-oxidationIMPbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0043518negative regulation of DNA damage response, signalIMPbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIEAbiological_process
GO:0033128negative regulation of histone phosphorylationIMPbiological_process
GO:0035067negative regulation of histone acetylationIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0007517muscle organ developmentIEAbiological_process
GO:0060900embryonic camera-type eye formationIMPbiological_process
GO:0071456cellular response to hypoxiaIMPbiological_process
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0061309cardiac neural crest cell development involved in IEAbiological_process
GO:0032720negative regulation of tumor necrosis factor produIEAbiological_process
GO:2000802positive regulation of endocardial cushion to meseIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0048701embryonic cranial skeleton morphogenesisIMPbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0045843negative regulation of striated muscle tissue deveIEAbiological_process
GO:2000793cell proliferation involved in heart valve developIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:2000276negative regulation of oxidative phosphorylation uIEAbiological_process