| UniProt/SwissProt ID: | HIPK1_HUMAN |
| Description: | homeodomain interacting protein kinase 1 [Source:HGNC Symbol;Acc:19006] |
| Location: | chr1 p13.2 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1001 | DCTVAtQASGL | HPRD | |
| S350 | SKAVCsTYLQS | Pkinase | PhosphoSitePlus |
| S967 | RGNSGsVLEGP | PhosphoSitePlus; HPRD | |
| T1027 | SGCCItPTGYR | PhosphoSitePlus | |
| Y357 | YLQSRyYRAPE | Pkinase | PhosphoSitePlus |
| T610 | GTGTRtIIVPP | HPRD | |
| S593 | RGNSGsVLEGP | HPRD | |
| S872 | SLVGSsPLRTT | PhosphoSitePlus | |
| S355 | STYLQsRYYRA | Pkinase | PhosphoSitePlus |
| T984 | GTGTRtIIVPP | HPRD | |
| Y358 | LQSRYyRAPEI | Pkinase | PhosphoSitePlus |
| S879 | LRTTSsYNSLV | PhosphoSitePlus | |
| T876 | SSPLRtTSSYN | PhosphoSitePlus | |
| T627 | DCTVAtQASGL | HPRD | |
| T607 | DCTVAtQASGL | HPRD | |
| S573 | RGNSGsVLEGP | HPRD | |
| T590 | GTGTRtIIVPP | HPRD | |
| S480 | SAPVSsKSSLD | HPRD | |
| Y352 | AVCSTyLQSRY | Pkinase | PhosphoSitePlus |
| T351 | KAVCStYLQSR | Pkinase | PhosphoSitePlus |
| S127 | GLKRKsEEVDS | PhosphoSitePlus | |
| S878 | PLRTTsSYNSL | PhosphoSitePlus | |
| S854 | SAPVSsKSSLD | PhosphoSitePlus; HPRD | |
| S460 | SAPVSsKSSLD | HPRD | |
| S1200 | TGYPLsPTKIS | PhosphoSitePlus | |
| Y1197 | TIYTGyPLSPT | PhosphoSitePlus | |
| T1202 | YPLSPtKISQY | PhosphoSitePlus | |
| Y352 | AVCSTyLQSRY | HPRD; phosphoELM | |
| T351 | KAVCStYLQSR | HPRD | |
| Dephosphorylation site |
| HIPK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358572 | K206E | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000340956 | I432V | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000358572 | A78D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000358572 | Y70* | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| HIPK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HIPK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HIPK1_HUMAN | CDK2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | CSN6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | BMX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | KPCD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | ECSIT_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | KS6A2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | MK01_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | HCLS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | CHK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | MAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | SPN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | NELFB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| HIPK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007224 | smoothened signaling pathway | IEA | biological_process |
| GO:0060216 | definitive hemopoiesis | ISS | biological_process |
| GO:0010842 | retina layer formation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042771 | intrinsic apoptotic signaling pathway in response | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045766 | positive regulation of angiogenesis | ISS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0030182 | neuron differentiation | IEA | biological_process |
| GO:0010803 | regulation of tumor necrosis factor-mediated signa | IDA | biological_process |
| GO:0061072 | iris morphogenesis | IEA | biological_process |
| GO:0060059 | embryonic retina morphogenesis in camera-type eye | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0060235 | lens induction in camera-type eye | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0009952 | anterior/posterior pattern specification | IEA | biological_process |
| GO:0048596 | embryonic camera-type eye morphogenesis | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0006915 | apoptotic process | IDA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |
| GO:0001654 | eye development | ISS | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |