Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DAB2_HUMAN
Description:disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) [Source:HGNC Symbol;Acc:2662]
Location:chr5 p13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S24APKAPsKKEKKPKCgRegPhos
S24APKAPsKKEKKPKC_groupphosphoELM; RegPhos
T221FGDMStPPDLNEntA_ImmunPhosphoSitePlus
S100VNISLsGIKIIPIDPhosphoSitePlus
S98IWVNIsLSGIKPIDPhosphoSitePlus
S24APKAPsKKEKKPRKCBHPRD
T329SSSSStPLSNGPhosphoSitePlus; HPRD
S24APKAPsKKEKKPRKCGHPRD
S24APKAPsKKEKKPRKCDHPRD
Y170LFQVIyNVKKKPID; EntA_ImmunPhosphoSitePlus
S324QKKENsSSSSTPhosphoSitePlus; HPRD
T151FFAIKtGQQAERegPhos
S723APRQVsLPVTKPhosphoSitePlus; HPRD; SysPTM
T437PPPQStKPGRGPhosphoSitePlus
S401NPFVGsPPKGLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y342NGDVDyFGQQFPhosphoSitePlus; HPRD; RegPhos; SysPTM
T151FFAIKtGQQAEPIDPhosphoSitePlus
S394FSVKSsPNPFVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S227PPDLNsPTESKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S231NSPTEsKDILLHPRD
T229DLNSPtESKDIHPRD
T730PVTKStDNAFEPhosphoSitePlus; SysPTM
Y685SAFASyFNSKVPhosphoSitePlus
T473GQASPtGQPTAHPRD
S24APKAPsKKEKKPKCbRegPhos
S24APKAPsKKEKKPKCdRegPhos
Y170LFQVIyNVKKKRegPhos
T221FGDMStPPDLNHPRD; phosphoELM; RegPhos
S316FDSLKsPDQKKPhosphoSitePlus
S24APKAPsKKEKKPhosphoSitePlus; phosphoELM
Y761VSSEMyRDPFGPhosphoSitePlus
S393GFSVKsSPNPFPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S423SSVQSsPHDSIPhosphoSitePlus
S24APKAPsKKEKKPKCa(PKC alphaRegPhos
S422ESSVQsSPHDSHPRD; SysPTM
S326KENSSsSSTPLPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
DAB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000313391Q13*BIOMARTBreast Cancer21930507, 21930502
ENSP00000313391P403LCOSMICSkin Cancer21984974
ENSP00000313391S382FCOSMICMelanoma
ENSP00000313391E230KCOSMICSkin Cancer21984974
ENSP00000313391D46NCOSMICRenal Cancer
ENSP00000313391L724MCOSMICRenal Cancer21248752
ENSP00000313391R661LCOSMICHead and Neck Cancer21798893
ENSP00000345508Q13*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
DAB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DAB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCB_HUMANDAB2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANDAB2_HUMANkinase -> substrateRegPhos
KPCD_HUMANDAB2_HUMANkinase -> substrateHPRD
KPCG_HUMANDAB2_HUMANkinase -> substrateHPRD
KPCA_HUMANDAB2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2000096positive regulation of Wnt receptor signaling pathIMPbiological_process
GO:0070022transforming growth factor beta receptor homodimerIDAcellular_component
GO:0000904cell morphogenesis involved in differentiationIEAbiological_process
GO:2000370positive regulation of clathrin-mediated endocytosIEAbiological_process
GO:0030511positive regulation of transforming growth factor IDAbiological_process
GO:0045785positive regulation of cell adhesionIEAbiological_process
GO:0035615clathrin adaptor activityIEAmolecular_function
GO:0010718positive regulation of epithelial to mesenchymal tIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0038024cargo receptor activityIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030276clathrin bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0060766negative regulation of androgen receptor signalingIMPbiological_process
GO:0030665clathrin-coated vesicle membraneIEAcellular_component
GO:0045807positive regulation of endocytosisIMPbiological_process
GO:0005905coated pitIDAcellular_component
GO:0032436positive regulation of proteasomal ubiquitin-depenIMPbiological_process
GO:0006907pinocytosisIEAbiological_process
GO:1900026positive regulation of substrate adhesion-dependenIEAbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIEAbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0006898receptor-mediated endocytosisIEAbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0035091phosphatidylinositol bindingIEAmolecular_function
GO:0015031protein transportIEAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0001921positive regulation of receptor recyclingIEAbiological_process
GO:0048268clathrin coat assemblyIEAbiological_process
GO:0032091negative regulation of protein bindingIMPbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0030099myeloid cell differentiationIEAbiological_process
GO:0035612AP-2 adaptor complex bindingIEAmolecular_function
GO:0008022protein C-terminus bindingIPImolecular_function
GO:2001046positive regulation of integrin-mediated signalingIEAbiological_process
GO:0030132clathrin coat of coated pitIEAcellular_component
GO:0007588excretionIEAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0007492endoderm developmentIEAbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:2000643positive regulation of early endosome to late endoIMPbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0071560cellular response to transforming growth factor beIEAbiological_process
GO:0032968positive regulation of transcription elongation frIEAbiological_process
GO:0007257activation of JUN kinase activityIEAbiological_process
GO:0060391positive regulation of SMAD protein import into nuIDAbiological_process