Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK10_HUMAN
Description:mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:6872]
Location:chr4 q21.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T131LLNVFtPQKTLCDK5HPRD; RegPhos
T221TSFMMtPYVVTMAP2K_groupphosphoELM; RegPhos
Y223FMMTPyVVTRYMAP2K4HPRD; phosphoELM; RegPhos
S415VKGQPsPSAQVHPRD
S270VKGQPsPSAQVHPRD
Y78FMMTPyVVTRYMAP2K4HPRD
T76TSFMMtPYVVTMAP2K4HPRD
S193RDLKPsNIVVKPkinasePhosphoSitePlus
T93LLNVFtPQKTLCDK5HPRD
T183TSFMMtPYVVTMAP2K4HPRD
T281IEQLGtPCPEFPkinasePhosphoSitePlus
Y185FMMTPyVVTRYMAP2K4HPRD
T226TPYVVtRYYRAPkinasePhosphoSitePlus
T216ARTAGtSFMMTPkinasePhosphoSitePlus
Y223FMMTPyVVTRYPkinasePhosphoSitePlus
Y223FMMTPyVVTRYphosphoELM; RegPhos
T221TSFMMtPYVVTPkinasePhosphoSitePlus
T221TSFMMtPYVVTMAP2K7phosphoELM; RegPhos
T221TSFMMtPYVVTMAP2K4HPRD; RegPhos
T221TSFMMtPYVVTphosphoELM; RegPhos
S217RTAGTsFMMTPPkinasePhosphoSitePlus

Dephosphorylation site
MK10_HUMAN do not have dephosphorylation site.

Mutation site
MK10_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000378595Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.3415169874

Hyperphosphorylation site
MK10_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK10_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANA4_HUMANkinase -> substrateRegPhos
MK10_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANJIP3_HUMANkinase -> substrateRegPhos
MK10_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANJIP1_HUMANkinase -> substrateRegPhos
MK10_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANMP2K7_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANATF2_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANATN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK10_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANHNRPK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MP2K4_HUMANMK10_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK10_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANB2L11_HUMANkinase -> substrateRegPhos
MK10_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANMK10_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANMK10_HUMANkinase -> substrateRegPhos
MK10_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANMEF2A_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANMK10_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05132Salmonella infection
hsa05142Chagas disease (American trypanosomiasis)
hsa05168Herpes simplex infection
hsa04920Adipocytokine signaling pathway
hsa05210Colorectal cancer
hsa04141Protein processing in endoplasmic reticulum
hsa05169Epstein-Barr virus infection
hsa05133Pertussis
hsa04010MAPK signaling pathway
hsa04310Wnt signaling pathway
hsa04930Type II diabetes mellitus
hsa05200Pathways in cancer
hsa04380Osteoclast differentiation
hsa05166HTLV-I infection
hsa04723Retrograde endocannabinoid signaling
hsa04664Fc epsilon RI signaling pathway
hsa05160Hepatitis C
hsa04728Dopaminergic synapse
hsa04722Neurotrophin signaling pathway
hsa05131Shigellosis
hsa04621NOD-like receptor signaling pathway
hsa05152Tuberculosis
hsa05212Pancreatic cancer
hsa04622RIG-I-like receptor signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04914Progesterone-mediated oocyte maturation
hsa04510Focal adhesion
hsa04912GnRH signaling pathway
hsa05164Influenza A
hsa05145Toxoplasmosis
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004707MAP kinase activityIEAmolecular_function
GO:0007258JUN phosphorylationISSbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004705JUN kinase activityISSmolecular_function
GO:0005886plasma membraneISScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0000187activation of MAPK activityTASbiological_process
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004708MAP kinase kinase activityTASmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0005739mitochondrionISScellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007254JNK cascadeISSbiological_process
GO:0016020membraneIEAcellular_component
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0005737cytoplasmISScellular_component