| UniProt/SwissProt ID: | GRM5_HUMAN |
| Description: | glutamate receptor, metabotropic 5 [Source:HGNC Symbol;Acc:4597] |
| Location: | chr11 q14.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T607 | IIYRDtPVVKS | 7tm_3 | PhosphoSitePlus |
| T841 | AFTTStVVRMH | PRKCA | HPRD |
| S840 | SAFTTsTVVRM | PRKCZ | HPRD |
| S840 | SAFTTsTVVRM | PRKCG | HPRD |
| S840 | SAFTTsTVVRM | PRKCD | HPRD |
| S840 | SAFTTsTVVRM | PRKCB | HPRD |
| S840 | SAFTTsTVVRM | PRKCA | HPRD |
| S654 | IGIGLsPAMSY | 7tm_3; TM | PhosphoSitePlus |
| S256 | NAGEQsFDKLL | ANF_receptor | PhosphoSitePlus |
| T282 | FCEGMtVRGLL | ANF_receptor | PhosphoSitePlus |
| S1020 | RPRSPsPISTL | PhosphoSitePlus | |
| S840 | SAFTTsTVVRM | PRKCQ | HPRD |
| S840 | SAFTTsTVVRM | PRKCE | HPRD |
| S266 | LKKLTsHLPKA | ANF_receptor | PhosphoSitePlus |
| S250 | SYKIYsNAGEQ | ANF_receptor | PhosphoSitePlus |
| Y619 | SRELCyIILAG | 7tm_3; TM | PhosphoSitePlus |
| Dephosphorylation site |
| GRM5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000305905 | R574* | COSMIC | Breast Cancer | 20668451 | ENSP00000306138 | W354G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000305905 | A855T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000402912 | R435W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000305905 | W354G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000306138 | R435W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000305905 | P536L | COSMIC | Skin Cancer | 21984974 | ENSP00000306138 | E527K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000402912 | W354G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000305905 | G92R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000305905 | P32L | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000305905 | R78K | COSMIC | Skin Cancer | 21984974 | ENSP00000405690 | E527K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000402912 | E527K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000402912 | D545H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000305905 | R128H | COSMIC | Lung Cancer | 20668451 | ENSP00000405690 | D545H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000305905 | R435W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000305905 | F818L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000305905 | D545H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000305905 | K51E | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000405690 | W354G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000405690 | R435W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000305905 | E527K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000305905 | N769I | COSMIC | Lung Cancer | 20668451 | ENSP00000306138 | D545H | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GRM5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRM5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | GRM5_HUMAN | kinase -> substrate | HPRD |
| KPCT_HUMAN | GRM5_HUMAN | kinase -> substrate | HPRD |
| KPCB_HUMAN | GRM5_HUMAN | kinase -> substrate | HPRD |
| KPCA_HUMAN | GRM5_HUMAN | kinase -> substrate | HPRD |
| KPCZ_HUMAN | GRM5_HUMAN | kinase -> substrate | HPRD |
| KPCG_HUMAN | GRM5_HUMAN | kinase -> substrate | HPRD |
| KPCE_HUMAN | GRM5_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04724 | Glutamatergic synapse |
| hsa04540 | Gap junction |
| hsa04720 | Long-term potentiation |
| hsa04020 | Calcium signaling pathway |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa05016 | Huntington's disease |
| hsa04730 | Long-term depression |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0043198 | dendritic shaft | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007626 | locomotory behavior | IEA | biological_process |
| GO:0007205 | protein kinase C-activating G-protein coupled rece | IEA | biological_process |
| GO:0040013 | negative regulation of locomotion | IEA | biological_process |
| GO:0002029 | desensitization of G-protein coupled receptor prot | IEA | biological_process |
| GO:0007206 | phospholipase C-activating G-protein coupled gluta | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0043197 | dendritic spine | IEA | cellular_component |
| GO:0008066 | glutamate receptor activity | TAS | molecular_function |
| GO:0007268 | synaptic transmission | IEA | biological_process |
| GO:0000185 | activation of MAPKKK activity | IEA | biological_process |
| GO:0048169 | regulation of long-term neuronal synaptic plastici | IEA | biological_process |
| GO:0048170 | positive regulation of long-term neuronal synaptic | IEA | biological_process |
| GO:0014069 | postsynaptic density | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007612 | learning | IEA | biological_process |
| GO:0031687 | A2A adenosine receptor binding | IEA | molecular_function |