Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTN22_HUMAN
Description:protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [Source:HGNC Symbol;Acc:9652]
Location:chr1 p13.2
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y499SAELNySLPYDPhosphoSitePlus
S653VKIGTsLEWGGPhosphoSitePlus
S527ALGVYsYIPLVPhosphoSitePlus
T173DYIIRtLKVKFY_phosphatasePhosphoSitePlus
T447VPITRtKSTPFPhosphoSitePlus
S500AELNYsLPYDSPhosphoSitePlus
Y536LVENPyFSSWPPhosphoSitePlus
Y528LGVYSyIPLVEPhosphoSitePlus
S449ITRTKsTPFELPhosphoSitePlus
S414LQKHQsLDLGSPhosphoSitePlus; HPRD
Y526SALGVySYIPLPhosphoSitePlus
S35KLKRQsTKYKAPhosphoSitePlus; HPRD

Dephosphorylation site
PTN22_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352833A98TCOSMICSkin Cancer21984974
ENSP00000352833D558YCOSMICHead and Neck Cancer21798893
ENSP00000352833R70PCOSMICRenal Cancer20054297
ENSP00000352833R690HCOSMICRenal Cancer20054297

Differential expressed protein
PTN22_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTN22_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANPTN22_HUMANkinase -> substrateHPRD
PTN22_HUMANZAP70_HUMANphosphatase -> substrateHPRD
PTN22_HUMANLCK_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
PTN22_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035644phosphoanandamide dephosphorylationIEAbiological_process
GO:0019900kinase bindingISSmolecular_function
GO:0017124SH3 domain bindingISSmolecular_function
GO:0030217T cell differentiationIEAbiological_process
GO:0019900kinase bindingIEAmolecular_function
GO:0004725protein tyrosine phosphatase activityIDAmolecular_function
GO:0050868negative regulation of T cell activationIMPbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0035335peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0009898internal side of plasma membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0050860negative regulation of T cell receptor signaling pIDAbiological_process
GO:0050855regulation of B cell receptor signaling pathwayNASbiological_process
GO:0035644phosphoanandamide dephosphorylationISSbiological_process
GO:0006470protein dephosphorylationIDAbiological_process
GO:0032817regulation of natural killer cell proliferationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030217T cell differentiationISSbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0045088regulation of innate immune responseICbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0009898internal side of plasma membraneIDAcellular_component
GO:0050868negative regulation of T cell activationIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0016791phosphatase activityIEAmolecular_function
GO:0006470protein dephosphorylationIEAbiological_process


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