| UniProt/SwissProt ID: | BPL1_HUMAN |
| Description: | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) [Source:HGNC Symbol;Acc:4976] |
| Location: | chr21 q22.13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S124 | SVKFAsAENIP | PhosphoSitePlus | |
| S147 | VADETsPEREG | PhosphoSitePlus; HPRD; phosphoELM | |
| Y635 | PLRADyLIARV | PhosphoSitePlus | |
| T642 | IARVVtVLEKL | PhosphoSitePlus | |
| S79 | KQRRGsASGSE | PhosphoSitePlus | |
| S81 | RRGSAsGSEPA | PhosphoSitePlus | |
| Y236 | QKFMAyLSQGG | PhosphoSitePlus | |
| S238 | FMAYLsQGGKV | PhosphoSitePlus | |
| T146 | SVADEtSPERE | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| BPL1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000382071 | N563S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000382071 | E42D | Sjoblom2006 | Breast Cancer | 16959974 | ENSP00000382071 | E42D | COSMIC | Breast Cancer | 16959974 | ENSP00000382071 | S83N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000382071 | N156K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000382071 | L399H | COSMIC | Hepatocellular Carcinoma |
| Differential expressed protein |
| BPL1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BPL1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M3K14_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN3_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK6_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TBK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TSSK2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK38_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EPHB1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| E2AK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK7_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK40_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK3_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMX_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FYN_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NRBP_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| LIMK2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK25_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MKNK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK11_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MATK_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAF1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EF2K_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ITK_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K7_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A4_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WNK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KCC1B_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCD_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK36_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FAK2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK10_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NLK_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MYO3A_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1A_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| UHMK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAST1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| LYN_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK24_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK3_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK14_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KAPCB_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GSK3B_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A5_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HCK_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAP70_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK3_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1G2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EPHA3_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK12_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| YES_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ABL2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| BPL1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0009374 | biotin binding | IDA | molecular_function |
| GO:0005652 | nuclear lamina | IDA | cellular_component |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0006464 | cellular protein modification process | IEA | biological_process |
| GO:0016363 | nuclear matrix | IDA | cellular_component |
| GO:0004078 | biotin-[methylcrotonoyl-CoA-carboxylase] ligase ac | IEA | molecular_function |
| GO:0018271 | biotin-protein ligase activity | IMP | molecular_function |
| GO:0000785 | chromatin | IDA | cellular_component |
| GO:0008283 | cell proliferation | IMP | biological_process |
| GO:0004077 | biotin-[acetyl-CoA-carboxylase] ligase activity | IEA | molecular_function |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0070781 | response to biotin | IEA | biological_process |
| GO:0009305 | protein biotinylation | IDA | biological_process |
| GO:0004079 | biotin-[methylmalonyl-CoA-carboxytransferase] liga | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016570 | histone modification | IDA | biological_process |
| GO:0004080 | biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing | IEA | molecular_function |
| GO:0071110 | histone biotinylation | IDA | biological_process |