Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RS6_HUMAN
Description:ribosomal protein S6 [Source:HGNC Symbol;Acc:10429]
Location:chr9 p22.1
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S247SKSESsHPRD; phosphoELM
S235KRRRLsSLRASp70_groupRegPhos
S235KRRRLsSLRASHPRD; phosphoELM; RegPhos
S235KRRRLsSLRASDUF4055PhosphoSitePlus
S6MKLNIsFPATGRibosomal_S6ePhosphoSitePlus
S244ASTSKsESSQKRegPhos
T241SLRAStSKSESDUF4055PhosphoSitePlus; SysPTM
S244ASTSKsESSQKDUF4055PhosphoSitePlus
S78VRLLLsKGHSCRibosomal_S6ePhosphoSitePlus; SysPTM
S148KLFNLsKEDDVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S236RRRLSsLRASTPKCd(PKC deltaRegPhos; SysPTM
S235KRRRLsSLRASPAK2HPRD; RegPhos
S236RRRLSsLRASTp70S6K_groupphosphoELM; SysPTM
S240SSLRAsTSKSEDUF4055PhosphoSitePlus; SysPTM
S247SKSESsQKRegPhos
S236RRRLSsLRASTRSK_groupphosphoELM; SysPTM
S246TSKSEsSQK__DUF4055PhosphoSitePlus
S236RRRLSsLRASTPAK2HPRD; RegPhos; SysPTM
S236RRRLSsLRASTp70_groupRegPhos; SysPTM
S244ASTSKsESSHPRD; phosphoELM
S240SSLRAsTSKSEHPRD; phosphoELM; RegPhos; SysPTM
S240SSLRAsTSKSEPAK2HPRD; RegPhos; SysPTM
S78VRLLLsKGHSCHPRD; phosphoELM; RegPhos; SysPTM
S242LRASTsKSESSphosphoELM; RegPhos
S236RRRLSsLRASTp70S6KphosphoELM; SysPTM
S242LRASTsKSESSDUF4055PhosphoSitePlus
S235KRRRLsSLRASp70S6K_groupphosphoELM
T241SLRAStSKSESHPRD; phosphoELM; SysPTM
S246TSKSEsSQKRegPhos
S235KRRRLsSLRASPKCd(PKC deltaRegPhos
S235KRRRLsSLRASp70S6KphosphoELM
S236RRRLSsLRASTDUF4055PhosphoSitePlus; SysPTM
S235KRRRLsSLRASRSK_groupphosphoELM
S236RRRLSsLRASTHPRD; phosphoELM; RegPhos; SysPTM
S247SKSESsQK___DUF4055PhosphoSitePlus
S242LRASTsKSESSPAK2HPRD; RegPhos
Y209EEAAEyAKLLADUF4055PhosphoSitePlus
T181IQRLVtPRVLQDUF4055PhosphoSitePlus; SysPTM
Y28KLRTFyEKRMARibosomal_S6ePhosphoSitePlus

Dephosphorylation site
RS6_HUMAN do not have dephosphorylation site.

Mutation site
RS6_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000369757Pancreatic CancerNormal vs. CancertissueDown0.4416230073

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S244DUF4055LRASTSKsESSQK__adrenocortical carcinoma20484036PhosphoSitePlus
S240DUF4055RLSSLRAsTSKSESSadrenocortical carcinoma20484036PhosphoSitePlus
S244DUF4055LRASTSKsESSQK__tuberous sclerosis17671177PhosphoSitePlus
S240DUF4055RLSSLRAsTSKSESStuberous sclerosis17671177PhosphoSitePlus
S235DUF4055IAKRRRLsSLRASTSKaposi's sarcoma21819957PhosphoSitePlus
S236DUF4055AKRRRLSsLRASTSKKaposi's sarcoma21819957PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KS6B1_HUMANRS6_HUMANkinase -> substrateNetPath
ZAGL2_HUMANRS6_HUMANkinase -> substrateRegPhos
PAK2_HUMANRS6_HUMANkinase -> substrateRegPhos
KPCD_HUMANRS6_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANRS6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa03010Ribosome
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0019083viral transcriptionTASbiological_process
GO:0006412translationIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0019058viral infectious cycleTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0000184nuclear-transcribed mRNA catabolic process, nonsenTASbiological_process
GO:0005840ribosomeIEAcellular_component
GO:0006364rRNA processingIMPbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0015935small ribosomal subunitIDAcellular_component
GO:0003735structural constituent of ribosomeIEAmolecular_function
GO:0031929TOR signaling cascadeIDAbiological_process
GO:0000028ribosomal small subunit assemblyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042274ribosomal small subunit biogenesisIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006414translational elongationTASbiological_process
GO:0022627cytosolic small ribosomal subunitIEAcellular_component
GO:0042593glucose homeostasisIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005730nucleolusIDAcellular_component
GO:0006413translational initiationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0006415translational terminationTASbiological_process
GO:0006614SRP-dependent cotranslational protein targeting toTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23