Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF4A3_HUMAN
Description:eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:18683]
Location:chr17 q25.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T163HVVAGtPGRVFDEADPhosphoSitePlus
Y205QIYDVyRYLPPDEADPhosphoSitePlus
Y202FKEQIyDVYRYDEADPhosphoSitePlus
T4TMATHPRD
T9TATMAtSGSARPhosphoSitePlus; HPRD
S12MATSGsARKRLPhosphoSitePlus; HPRD
Y56RGIYAyGFEKPPhosphoSitePlus
Y155IRKLDyGQHVVDEADPhosphoSitePlus
T6ATSGHPRD
Y54LLRGIyAYGFEPhosphoSitePlus
T163HVVAGtPGRVFHPRD; phosphoELM
S10ATMATsGSARKPhosphoSitePlus; HPRD
T247KRDELtLEGIKPhosphoSitePlus

Dephosphorylation site
IF4A3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000269349R370QCOSMICHead and Neck Cancer21798893
ENSP00000269349A377PCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000269349Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000269349Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y54EDLLRGIyAYGFEKPcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
STK38_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
IF4A3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016071mRNA metabolic processTASbiological_process
GO:0004386helicase activityIEAmolecular_function
GO:0000289nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0017148negative regulation of translationIDAbiological_process
GO:0051028mRNA transportIEAbiological_process
GO:0006364rRNA processingIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048026positive regulation of mRNA splicing, via spliceosIEAbiological_process
GO:0016607nuclear speckIEAcellular_component
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0004004ATP-dependent RNA helicase activityIDAmolecular_function
GO:0000184nuclear-transcribed mRNA catabolic process, nonsenIMPbiological_process
GO:0008143poly(A) RNA bindingIDAmolecular_function
GO:0000288nuclear-transcribed mRNA catabolic process, deadenTASbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0035145exon-exon junction complexIDAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0045727positive regulation of translationIMPbiological_process


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