| UniProt/SwissProt ID: | EF1A1_HUMAN |
| Description: | eukaryotic translation elongation factor 1 alpha 1 [Source:HGNC Symbol;Acc:3189] |
| Location: | chr6 q13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T82 | LWKFEtSKYYV | GTP_EFTU | PhosphoSitePlus |
| Y29 | TGHLIyKCGGI | HPRD; phosphoELM; RegPhos | |
| Y167 | YSQKRyEEIVK | GTP_EFTU | PhosphoSitePlus |
| Y85 | FETSKyYVTII | GTP_EFTU | PhosphoSitePlus |
| Y141 | HALLAyTLGVK | HPRD; phosphoELM; RegPhos | |
| T88 | SKYYVtIIDAP | GTP_EFTU | PhosphoSitePlus |
| S157 | VNKMDsTEPPY | GTP_EFTU | PhosphoSitePlus |
| S383 | KIDRRsGKKLE | GTP_EFTU_D3 | PhosphoSitePlus |
| T176 | VKEVStYIKKI | GTP_EFTU | PhosphoSitePlus |
| T432 | RDMRQtVAVGV | PRKCD | HPRD |
| Y177 | KEVSTyIKKIG | GTP_EFTU | PhosphoSitePlus |
| Y254 | PLQDVyKIGGI | PhosphoSitePlus; HPRD | |
| S300 | HHEALsEALPG | GTP_EFTU_D2 | PhosphoSitePlus |
| T24 | GKSTTtGHLIY | GTP_EFTU | PhosphoSitePlus |
| T22 | DSGKStTTGHL | GTP_EFTU | PhosphoSitePlus |
| T142 | ALLAYtLGVKQ | GTP_EFTU | PhosphoSitePlus |
| T269 | VGRVEtGVLKP | GTP_EFTU_D2 | PhosphoSitePlus |
| Y86 | ETSKYyVTIID | GTP_EFTU | PhosphoSitePlus |
| T242 | PPTRPtDKPLR | HPRD | |
| T23 | SGKSTtTGHLI | GTP_EFTU | PhosphoSitePlus |
| T432 | RDMRQtVAVGV | PKC_group | phosphoELM; RegPhos |
| T432 | RDMRQtVAVGV | GTP_EFTU_D3 | PhosphoSitePlus |
| T133 | SKNGQtREHAL | GTP_EFTU | PhosphoSitePlus |
| Y162 | STEPPySQKRY | GTP_EFTU | PhosphoSitePlus; SysPTM |
| Y357 | QISAGyAPVLD | GTP_EFTU_D3 | PhosphoSitePlus |
| T158 | NKMDStEPPYS | GTP_EFTU | PhosphoSitePlus |
| Y141 | HALLAyTLGVK | GTP_EFTU | PhosphoSitePlus |
| T6 | INIV | HPRD | |
| Y29 | TGHLIyKCGGI | GTP_EFTU | PhosphoSitePlus |
| S163 | TEPPYsQKRYE | GTP_EFTU | PhosphoSitePlus |
| S76 | ITIDIsLWKFE | GTP_EFTU | PhosphoSitePlus |
| S128 | FEAGIsKNGQT | GTP_EFTU | PhosphoSitePlus |
| T261 | IGGIGtVPVGR | GTP_EFTU_D2 | PhosphoSitePlus |
| T432 | RDMRQtVAVGV | PKCd | RegPhos |
| T24 | GKSTTtGHLIY | HPRD | |
| S21 | VDSGKsTTTGH | HPRD | |
| Y86 | ETSKYyVTIID | HPRD; phosphoELM | |
| Y162 | STEPPySQKRY | HPRD; phosphoELM; RegPhos; SysPTM | |
| S414 | PMCVEsFSDYP | GTP_EFTU_D3 | PhosphoSitePlus |
| T106 | NMITGtSQADC | GTP_EFTU | PhosphoSitePlus |
| Y418 | ESFSDyPPLGR | GTP_EFTU_D3 | PhosphoSitePlus |
| S21 | VDSGKsTTTGH | GTP_EFTU | PhosphoSitePlus |
| Dephosphorylation site |
| EF1A1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000330054 | G265D | COSMIC | Skin Cancer | 21984974 | ENSP00000339063 | G265D | COSMIC | Skin Cancer | 21984974 | ENSP00000339053 | G265D | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000330054 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 3.4 | 17627933 | ENSP00000330054 | Breast Cancer | Treatment (none vs. 17b-Estradiol treatment) | cell line | Up | 3.2 | 18491314 | ENSP00000330054 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | ENSP00000330054 | Neoplasms by Histologic Type | Cancer vs. Cancer | cell line | Up | 15750928 | ENSP00000330054 | Neoplasms by Histologic Type | Cancer vs. Cancer | cell line | Up | 15750928 | ENSP00000330054 | Breast Cancer | Cancer vs. Cancer (Non-TNBC vs. TNBC) | cell line | Up | 20596302 | ENSP00000330054 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000330054 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Up | 1.4 | 20625496 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S300 | GTP_EFTU_D2 | EMHHEALsEALPGDN | breast ductal carcinoma | 20832312 | PhosphoSitePlus | Y29 | GTP_EFTU | TTTGHLIyKCGGIDK | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | EF1A1_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | EF1A1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05134 | Legionellosis |
| hsa03013 | RNA transport |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006412 | translation | TAS | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0006414 | translational elongation | TAS | biological_process |
| GO:0003746 | translation elongation factor activity | IEA | molecular_function |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005853 | eukaryotic translation elongation factor 1 complex | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |