Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDK9_HUMAN
Description:cyclin-dependent kinase 9 [Source:HGNC Symbol;Acc:1780]
Location:chr9 q34.11
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S353QITQQsTNQSRPhosphoSitePlus; HPRD
S347PRRKGsQITQQPhosphoSitePlus; HPRD
Y338TSMFEyLAPPRPhosphoSitePlus
Y185SQPNRyTNRVVPkinasePhosphoSitePlus
S180SLAKNsQPNRYHPRD
T186QPNRYtNRVVTHPRD; phosphoELM
S175LARAFsLAKNSphosphoELM
T363RNPATtNQTEFPhosphoSitePlus
T366ATTNQtEFERVPhosphoSitePlus
T350KGSQItQQSTNPhosphoSitePlus
T362SRNPAtTNQTEPhosphoSitePlus
S357QSTNQsRNPATPhosphoSitePlus
T354ITQQStNQSRNPhosphoSitePlus
Y194VVTLWyRPPELPkinasePhosphoSitePlus
T186QPNRYtNRVVTPkinasePhosphoSitePlus
S175LARAFsLAKNSPkinasePhosphoSitePlus
T333LSTHLtSMFEYHPRD
S334STHLTsMFEYLHPRD
T330KGMLStHLTSMHPRD

Dephosphorylation site
CDK9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362361A215TBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000362361D323NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
CDK9_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDK9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK9_HUMANPTBP1_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANANDR_HUMANkinase -> substrateNetPath
BTK_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANHMGN3_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANRPB1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK9_HUMANP53_HUMANkinase -> substrateRegPhos
CDK9_HUMANSPT5H_HUMANkinase -> substrateRegPhos
CDK9_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0031056regulation of histone modificationIDAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0008353RNA polymerase II carboxy-terminal domain kinase aIDAmolecular_function
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0071157negative regulation of cell cycle arrestIDAbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:0016605PML bodyIDAcellular_component
GO:0007049cell cycleTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071345cellular response to cytokine stimulusIDAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0017069snRNA bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0043111replication fork arrestIDAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyTASbiological_process
GO:0006282regulation of DNA repairIDAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0008024positive transcription elongation factor complex bIDAcellular_component
GO:0016032viral reproductionTASbiological_process
GO:0008023transcription elongation factor complexTAScellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process


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