Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL6RB_HUMAN
Description:interleukin 6 signal transducer (gp130, oncostatin M receptor) [Source:HGNC Symbol;Acc:6021]
Location:chr5 q11.2
Node attribute:receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S780QVFSRsESTQPPhosphoSitePlus; HPRD; phosphoELM
S678RHNFNsKDQMYPhosphoSitePlus; HPRD
Y915VRQGGyMphosphoELM
S820FKQNCsQHESSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y759SSTVQySTVVHPhosphoSitePlus; phosphoELM; RegPhos
T783SRSEStQPLLDHPRD; phosphoELM
S667HIAQWsPHTPPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T890VERFEtVGMEAPhosphoSitePlus
T890VERFEtVGMEAPRKCDHPRD
T909SYLPQtVRQGGPKCdRegPhos
T909SYLPQtVRQGGPRKCDHPRD
Y915VRQGGyMPQRegPhos
T670QWSPHtPPRHNPhosphoSitePlus; HPRD; SysPTM
Y814LPRQQyFKQNCPhosphoSitePlus; phosphoELM; RegPhos
Y683SKDQMySDGNFphosphoELM; RegPhos
S782FSRSEsTQPLLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y322ASGITyEDRPSPhosphoSitePlus
S829SSPDIsHFERSHPRD; phosphoELM; RegPhos; SysPTM
Y905GMPKSyLPQTVPhosphoSitePlus; phosphoELM; RegPhos
T890VERFEtVGMEAPKCd(PKC deltaRegPhos
Y309EDGKGyWSDWSfn3PhosphoSitePlus
S839SKQVSsVNEEDPhosphoSitePlus; HPRD
Y915VRQGGyMPQ__PhosphoSitePlus
S824CSQHEsSPDISHPRD
S710PEDLKsLDLFKPhosphoSitePlus; HPRD
Y767VVHSGyRHQVPPhosphoSitePlus; phosphoELM; RegPhos
T897GMEAAtDEGMPPhosphoSitePlus
T890VERFEtVGMEAPKC_deltaphosphoELM
T890VERFEtVGMEAPKCdRegPhos
Y396LTNDRyLATLTPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y759NTSSTVQySTVVHSGPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000370698D585VCOSMICHead and Neck Cancer21798893
ENSP00000338799T415IHPIColorectal Cancer16959974
ENSP00000370698T415IHPIColorectal Cancer16959974
ENSP00000338799T415ISjoblom2006, COSMICIntestines Cancer16959974
ENSP00000370698T424ICOSMICHead and Neck Cancer21798893
ENSP00000338799D585VCOSMICHead and Neck Cancer21798893
ENSP00000370698T415ISjoblom2006, COSMICIntestines Cancer16959974
ENSP00000338799T424ICOSMICHead and Neck Cancer21798893

Differential expressed protein
IL6RB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL6RB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IL6_HUMANIL6RB_HUMANligand -> receptorHPMR
KPCD_HUMANIL6RB_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
JAK2_HUMANIL6RB_HUMANkinase -> substrateNetPath
ZAGL2_HUMANIL6RB_HUMANkinase -> substrateRegPhos
PTN11_HUMANIL6RB_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa05203Viral carcinogenesis
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0038165oncostatin-M-mediated signaling pathwayIDAbiological_process
GO:0019981interleukin-6 bindingIPImolecular_function
GO:0042803protein homodimerization activityTASmolecular_function
GO:0048711positive regulation of astrocyte differentiationIEAbiological_process
GO:0002675positive regulation of acute inflammatory responseICbiological_process
GO:0070106interleukin-27-mediated signaling pathwayIMPbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0070110ciliary neurotrophic factor receptor complexIDAcellular_component
GO:0004921interleukin-11 receptor activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0070104negative regulation of interleukin-6-mediated signIDAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0042102positive regulation of T cell proliferationIMPbiological_process
GO:0005138interleukin-6 receptor bindingIPImolecular_function
GO:0070120ciliary neurotrophic factor-mediated signaling patIDAbiological_process
GO:0005896interleukin-6 receptor complexIDAcellular_component
GO:0004915interleukin-6 receptor activityIGImolecular_function
GO:0010575positive regulation vascular endothelial growth faTASbiological_process
GO:0005977glycogen metabolic processIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0005900oncostatin-M receptor complexIDAcellular_component
GO:0002821positive regulation of adaptive immune responseICbiological_process
GO:0004924oncostatin-M receptor activityIDAmolecular_function
GO:0010613positive regulation of cardiac muscle hypertrophyTASbiological_process
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0004923leukemia inhibitory factor receptor activityIGImolecular_function
GO:0004897ciliary neurotrophic factor receptor activityIDAmolecular_function
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0019838growth factor bindingIPImolecular_function
GO:0034097response to cytokine stimulusIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008593regulation of Notch signaling pathwayIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0048861leukemia inhibitory factor signaling pathwayIGIbiological_process
GO:0070102interleukin-6-mediated signaling pathwayIGIbiological_process
GO:0045509interleukin-27 receptor activityICmolecular_function
GO:0044297cell bodyIEAcellular_component
GO:0005127ciliary neurotrophic factor receptor bindingIPImolecular_function
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0038154interleukin-11-mediated signaling pathwayIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0005576extracellular regionTAScellular_component
GO:0019970interleukin-11 bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0042511positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process