| UniProt/SwissProt ID: | NCF4_HUMAN |
| Description: | neutrophil cytosolic factor 4, 40kDa [Source:HGNC Symbol;Acc:7662] |
| Location: | chr22 q12.3 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T154 | RLRPRtRKVKS | PKC_group | phosphoELM; RegPhos |
| S315 | ARGLPsQKRLF | PKCa(PKC alpha | RegPhos |
| T154 | RLRPRtRKVKS | PKCa(PKC alpha | RegPhos |
| Y243 | NWLRCyYYEDT | PB1 | PhosphoSitePlus |
| T154 | RLRPRtRKVKS | PRKCD | HPRD |
| S315 | ARGLPsQKRLF | PKC_alpha | phosphoELM |
| Y245 | LRCYYyEDTIS | PB1 | PhosphoSitePlus |
| T154 | RLRPRtRKVKS | PhosphoSitePlus; RegPhos | |
| T154 | RLRPRtRKVKS | PKCd | RegPhos |
| S11 | QLRAEsDFEQL | PhosphoSitePlus | |
| S315 | ARGLPsQKRLF | PB1 | PhosphoSitePlus |
| S315 | ARGLPsQKRLF | RegPhos | |
| S23 | DDVAIsANIAD | PhosphoSitePlus | |
| T154 | RLRPRtRKVKS | PKC_alpha | phosphoELM |
| S161 | KVKSVsPQGNS | PhosphoSitePlus | |
| Dephosphorylation site |
| NCF4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000248899 | A102T | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000248899 | R105Q | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| NCF4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NCF4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | NCF4_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | NCF4_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | NCF4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SPI1_HUMAN | NCF4_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05140 | Leishmaniasis |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04380 | Osteoclast differentiation |
| hsa04145 | Phagosome |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0002474 | antigen processing and presentation of peptide ant | TAS | biological_process |
| GO:0051701 | interaction with host | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0032010 | phagolysosome | TAS | cellular_component |
| GO:0055114 | oxidation-reduction process | TAS | biological_process |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0042590 | antigen processing and presentation of exogenous p | TAS | biological_process |
| GO:0046983 | protein dimerization activity | TAS | molecular_function |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0090382 | phagosome maturation | TAS | biological_process |
| GO:0043020 | NADPH oxidase complex | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0002479 | antigen processing and presentation of exogenous p | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007154 | cell communication | IEA | biological_process |
| GO:0035091 | phosphatidylinositol binding | IEA | molecular_function |