Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CLAT_HUMAN
Description:choline O-acetyltransferase [Source:HGNC Symbol;Acc:1912]
Location:chr10 q11.23
Node attribute:ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T373LVKDStNRDSLPRKCAHPRD
T553RRLVPtYESASCarn_acyltransfPhosphoSitePlus
S476AAVPAsEKLLLPRKCZHPRD
S476AAVPAsEKLLLPRKCBHPRD
S476AAVPAsEKLLLPRKCGHPRD
S476AAVPAsEKLLLPRKCDHPRD
T456NIRSAtPEALACAMK2GHPRD
T456NIRSAtPEALACAMK2AHPRD
T574NIRSAtPEALACAMK2GHPRD
T574NIRSAtPEALACAMK2AHPRD
T255LVKDStNRDSLPRKCBHPRD
T255LVKDStNRDSLPRKCAHPRD
T255LVKDStNRDSLPRKCGHPRD
S475RADSVsELPAPHPRD
S357RADSVsELPAPHPRD
S558TYESAsIRRFQPRKCZHPRD
S558TYESAsIRRFQPRKCBHPRD
S558TYESAsIRRFQPRKCGHPRD
S558TYESAsIRRFQPRKCDHPRD
S558TYESAsIRRFQPRKCEHPRD
S475RADSVsELPAPCarn_acyltransfPhosphoSitePlus
S125AAKTPsSEESGPhosphoSitePlus
S465HMTQSsRKLIRPRKCGHPRD
S465HMTQSsRKLIRPRKCAHPRD
S558TYESAsIRRFQPRKCAHPRD
S440TYESAsIRRFQPRKCAHPRD
S440TYESAsIRRFQPRKCBHPRD
S440TYESAsIRRFQPRKCDHPRD
S440TYESAsIRRFQPRKCEHPRD
S440TYESAsIRRFQPRKCGHPRD
S440TYESAsIRRFQPRKCZHPRD
Y554RLVPTyESASICarn_acyltransfPhosphoSitePlus
T462LLKHVtQSSRKCarn_acyltransfPhosphoSitePlus
S464KHMTQsSRKLIPRKCBHPRD
S464KHMTQsSRKLIPRKCAHPRD
S464KHMTQsSRKLIPRKCGHPRD
S594AAVPAsEKLLLPRKCGHPRD
S594AAVPAsEKLLLPRKCEHPRD
S594AAVPAsEKLLLPRKCBHPRD
S594AAVPAsEKLLLPRKCAHPRD
S594AAVPAsEKLLLPRKCZHPRD
T123KMAAKtPSSEEPhosphoSitePlus
S377STNRDsLDMIECarn_acyltransfPhosphoSitePlus
S473LIRADsVSELPCarn_acyltransfPhosphoSitePlus
S346KHMTQsSRKLIPRKCGHPRD
S346KHMTQsSRKLIPRKCAHPRD
S346KHMTQsSRKLIPRKCBHPRD
T373LVKDStNRDSLPRKCBHPRD
T373LVKDStNRDSLPRKCGHPRD
S594AAVPAsEKLLLPRKCDHPRD
S476AAVPAsEKLLLPRKCAHPRD
S476AAVPAsEKLLLPRKCEHPRD
T25EEGGGtRGRREPhosphoSitePlus
S347HMTQSsRKLIRPRKCAHPRD
S347HMTQSsRKLIRPRKCBHPRD
S347HMTQSsRKLIRPRKCGHPRD
S465HMTQSsRKLIRPRKCBHPRD

Dephosphorylation site
CLAT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000337103G130ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000337103R323HCOSMICCentral Nervous System Neoplasms18772890
ENSP00000343486G12ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000345878R205HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000345878G12ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000378926R205HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000343486R205HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000378929*667YCOSMICOvarian Cancer21720365
ENSP00000378926G12ETCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
CLAT_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CLAT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLAT_HUMANACM4_HUMANligand -> receptorHPMR
CLAT_HUMANACM1_HUMANligand -> receptorHPMR
CLAT_HUMANACM2_HUMANligand -> receptorHPMR
CLAT_HUMANACM5_HUMANligand -> receptorHPMR
CLAT_HUMANACM3_HUMANligand -> receptorHPMR
KPCA_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCG_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCZ_HUMANCLAT_HUMANkinase -> substrateHPRD
KCC2A_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCE_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCD_HUMANCLAT_HUMANkinase -> substrateHPRD
KCC2G_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCB_HUMANCLAT_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04725Cholinergic synapse
hsa00564Glycerophospholipid metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005634nucleusTAScellular_component
GO:0007268synaptic transmissionIEAbiological_process
GO:0007269neurotransmitter secretionTASbiological_process
GO:0004102choline O-acetyltransferase activityIEAmolecular_function
GO:0030182neuron differentiationIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0006656phosphatidylcholine biosynthetic processTASbiological_process
GO:0030424axonIEAcellular_component
GO:0007517muscle organ developmentIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0007628adult walking behaviorIEAbiological_process
GO:0007274neuromuscular synaptic transmissionIEAbiological_process
GO:0046474glycerophospholipid biosynthetic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0016358dendrite developmentIEAbiological_process
GO:0007529establishment of synaptic specificity at neuromuscIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0043179rhythmic excitationIEAbiological_process
GO:0042136neurotransmitter biosynthetic processIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0016746transferase activity, transferring acyl groupsIEAmolecular_function
GO:0007622rhythmic behaviorIEAbiological_process


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