UniProt/SwissProt ID: | CLAT_HUMAN |
Description: | choline O-acetyltransferase [Source:HGNC Symbol;Acc:1912] |
Location: | chr10 q11.23 |
Node attribute: | ligand; substrate |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
T373 | LVKDStNRDSL | PRKCA | HPRD |
T553 | RRLVPtYESAS | Carn_acyltransf | PhosphoSitePlus |
S476 | AAVPAsEKLLL | PRKCZ | HPRD |
S476 | AAVPAsEKLLL | PRKCB | HPRD |
S476 | AAVPAsEKLLL | PRKCG | HPRD |
S476 | AAVPAsEKLLL | PRKCD | HPRD |
T456 | NIRSAtPEALA | CAMK2G | HPRD |
T456 | NIRSAtPEALA | CAMK2A | HPRD |
T574 | NIRSAtPEALA | CAMK2G | HPRD |
T574 | NIRSAtPEALA | CAMK2A | HPRD |
T255 | LVKDStNRDSL | PRKCB | HPRD |
T255 | LVKDStNRDSL | PRKCA | HPRD |
T255 | LVKDStNRDSL | PRKCG | HPRD |
S475 | RADSVsELPAP | HPRD | |
S357 | RADSVsELPAP | HPRD | |
S558 | TYESAsIRRFQ | PRKCZ | HPRD |
S558 | TYESAsIRRFQ | PRKCB | HPRD |
S558 | TYESAsIRRFQ | PRKCG | HPRD |
S558 | TYESAsIRRFQ | PRKCD | HPRD |
S558 | TYESAsIRRFQ | PRKCE | HPRD |
S475 | RADSVsELPAP | Carn_acyltransf | PhosphoSitePlus |
S125 | AAKTPsSEESG | PhosphoSitePlus | |
S465 | HMTQSsRKLIR | PRKCG | HPRD |
S465 | HMTQSsRKLIR | PRKCA | HPRD |
S558 | TYESAsIRRFQ | PRKCA | HPRD |
S440 | TYESAsIRRFQ | PRKCA | HPRD |
S440 | TYESAsIRRFQ | PRKCB | HPRD |
S440 | TYESAsIRRFQ | PRKCD | HPRD |
S440 | TYESAsIRRFQ | PRKCE | HPRD |
S440 | TYESAsIRRFQ | PRKCG | HPRD |
S440 | TYESAsIRRFQ | PRKCZ | HPRD |
Y554 | RLVPTyESASI | Carn_acyltransf | PhosphoSitePlus |
T462 | LLKHVtQSSRK | Carn_acyltransf | PhosphoSitePlus |
S464 | KHMTQsSRKLI | PRKCB | HPRD |
S464 | KHMTQsSRKLI | PRKCA | HPRD |
S464 | KHMTQsSRKLI | PRKCG | HPRD |
S594 | AAVPAsEKLLL | PRKCG | HPRD |
S594 | AAVPAsEKLLL | PRKCE | HPRD |
S594 | AAVPAsEKLLL | PRKCB | HPRD |
S594 | AAVPAsEKLLL | PRKCA | HPRD |
S594 | AAVPAsEKLLL | PRKCZ | HPRD |
T123 | KMAAKtPSSEE | PhosphoSitePlus | |
S377 | STNRDsLDMIE | Carn_acyltransf | PhosphoSitePlus |
S473 | LIRADsVSELP | Carn_acyltransf | PhosphoSitePlus |
S346 | KHMTQsSRKLI | PRKCG | HPRD |
S346 | KHMTQsSRKLI | PRKCA | HPRD |
S346 | KHMTQsSRKLI | PRKCB | HPRD |
T373 | LVKDStNRDSL | PRKCB | HPRD |
T373 | LVKDStNRDSL | PRKCG | HPRD |
S594 | AAVPAsEKLLL | PRKCD | HPRD |
S476 | AAVPAsEKLLL | PRKCA | HPRD |
S476 | AAVPAsEKLLL | PRKCE | HPRD |
T25 | EEGGGtRGRRE | PhosphoSitePlus | |
S347 | HMTQSsRKLIR | PRKCA | HPRD |
S347 | HMTQSsRKLIR | PRKCB | HPRD |
S347 | HMTQSsRKLIR | PRKCG | HPRD |
S465 | HMTQSsRKLIR | PRKCB | HPRD |
Dephosphorylation site |
CLAT_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000337103 | G130E | COSMIC | Central Nervous System Neoplasms | 18772890 |
ENSP00000337103 | R323H | COSMIC | Central Nervous System Neoplasms | 18772890 |
ENSP00000343486 | G12E | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
ENSP00000345878 | R205H | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
ENSP00000345878 | G12E | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
ENSP00000378926 | R205H | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
ENSP00000343486 | R205H | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
ENSP00000378929 | *667Y | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000378926 | G12E | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
Differential expressed protein |
CLAT_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
CLAT_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
CLAT_HUMAN | ACM4_HUMAN | ligand -> receptor | HPMR |
CLAT_HUMAN | ACM1_HUMAN | ligand -> receptor | HPMR |
CLAT_HUMAN | ACM2_HUMAN | ligand -> receptor | HPMR |
CLAT_HUMAN | ACM5_HUMAN | ligand -> receptor | HPMR |
CLAT_HUMAN | ACM3_HUMAN | ligand -> receptor | HPMR |
KPCA_HUMAN | CLAT_HUMAN | kinase -> substrate | HPRD |
KPCG_HUMAN | CLAT_HUMAN | kinase -> substrate | HPRD |
KPCZ_HUMAN | CLAT_HUMAN | kinase -> substrate | HPRD |
KCC2A_HUMAN | CLAT_HUMAN | kinase -> substrate | HPRD |
KPCE_HUMAN | CLAT_HUMAN | kinase -> substrate | HPRD |
KPCD_HUMAN | CLAT_HUMAN | kinase -> substrate | HPRD |
KCC2G_HUMAN | CLAT_HUMAN | kinase -> substrate | HPRD |
KPCB_HUMAN | CLAT_HUMAN | kinase -> substrate | HPRD |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04725 | Cholinergic synapse |
hsa00564 | Glycerophospholipid metabolism |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0043025 | neuronal cell body | IEA | cellular_component |
GO:0005634 | nucleus | TAS | cellular_component |
GO:0007268 | synaptic transmission | IEA | biological_process |
GO:0007269 | neurotransmitter secretion | TAS | biological_process |
GO:0004102 | choline O-acetyltransferase activity | IEA | molecular_function |
GO:0030182 | neuron differentiation | IEA | biological_process |
GO:0007268 | synaptic transmission | TAS | biological_process |
GO:0005739 | mitochondrion | IEA | cellular_component |
GO:0006656 | phosphatidylcholine biosynthetic process | TAS | biological_process |
GO:0030424 | axon | IEA | cellular_component |
GO:0007517 | muscle organ development | IEA | biological_process |
GO:0044281 | small molecule metabolic process | TAS | biological_process |
GO:0006644 | phospholipid metabolic process | TAS | biological_process |
GO:0007628 | adult walking behavior | IEA | biological_process |
GO:0007274 | neuromuscular synaptic transmission | IEA | biological_process |
GO:0046474 | glycerophospholipid biosynthetic process | TAS | biological_process |
GO:0005829 | cytosol | TAS | cellular_component |
GO:0016358 | dendrite development | IEA | biological_process |
GO:0007529 | establishment of synaptic specificity at neuromusc | IEA | biological_process |
GO:0005737 | cytoplasm | TAS | cellular_component |
GO:0043179 | rhythmic excitation | IEA | biological_process |
GO:0042136 | neurotransmitter biosynthetic process | IEA | biological_process |
GO:0043005 | neuron projection | IEA | cellular_component |
GO:0016746 | transferase activity, transferring acyl groups | IEA | molecular_function |
GO:0007622 | rhythmic behavior | IEA | biological_process |