Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SDC4_HUMAN
Description:syndecan 4 [Source:HGNC Symbol;Acc:10661]
Location:chr20 q13.12
Node attribute:receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y180KDEGSyDLGKKGlycophorin_A; Syndecan; PhosphoSitePlus
S179KKDEGsYDLGKPRKCDHPRD
S179KKDEGsYDLGKPRKCAHPRD
S179KKDEGsYDLGKPKCaRegPhos
S179KKDEGsYDLGKPKCdRegPhos
S179KKDEGsYDLGKphosphoELM; RegPhos
S179KKDEGsYDLGKGlycophorin_A; Syndecan; PhosphoSitePlus
T134VSMSStVQGSNGlycophorin_A; Syndecan; PhosphoSitePlus
Y197PTNEFHPRD; phosphoELM; SysPTM
Y197PTNEFyA____Herpes_gEPhosphoSitePlus; SysPTM

Dephosphorylation site
SDC4_HUMAN do not have dephosphorylation site.

Mutation site
SDC4_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000361818Breast CancerMetastasiscell lineDown18729497
ENSP00000361818Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
SDC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGF2_HUMANSDC4_HUMANligand -> receptorHPMR
ADA12_HUMANSDC4_HUMANligand -> receptorHPMR
ZAGL2_HUMANSDC4_HUMANkinase -> substrateRegPhos
KPCA_HUMANSDC4_HUMANkinase -> substrateHPRD
KPCD_HUMANSDC4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04512ECM-receptor interaction
hsa05144Malaria
hsa04514Cell adhesion molecules (CAMs)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045121membrane raftIEAcellular_component
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006027glycosaminoglycan catabolic processTASbiological_process
GO:0005925focal adhesionIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0043202lysosomal lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006024glycosaminoglycan biosynthetic processTASbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0008150biological_processNDbiological_process
GO:0051894positive regulation of focal adhesion assemblyIEAbiological_process
GO:0030204chondroitin sulfate metabolic processTASbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0001968fibronectin bindingIEAmolecular_function
GO:0001657ureteric bud developmentIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0008092cytoskeletal protein bindingIEAmolecular_function
GO:0030203glycosaminoglycan metabolic processTASbiological_process
GO:0051496positive regulation of stress fiber assemblyIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005080protein kinase C bindingIEAmolecular_function
GO:0005887integral to plasma membraneNAScellular_component
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0070053thrombospondin receptor activityIMPmolecular_function
GO:0043034costamereIEAcellular_component


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