Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GNAZ_HUMAN
Description:guanine nucleotide binding protein (G protein), alpha z polypeptide [Source:HGNC Symbol;Acc:4395]
Location:chr22 q11.22
Node attribute:Gprotein; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S16EAARRsRRIDRG-alpha; DUF2951PhosphoSitePlus
S16EAARRsRRIDRPRKCDHPRD
S27HLRSEsQRQRRPKC_groupphosphoELM
S16EAARRsRRIDRPKC_alphaphosphoELM
S142AQACFsRSSEYG-alphaPhosphoSitePlus
S229FCVELsGYDLKG-alphaPhosphoSitePlus
S27HLRSEsQRQRRPKC_alphaphosphoELM
T341VFDAVtDVIIQG-alphaPhosphoSitePlus
T263NWFINtSLILFG-alphaPhosphoSitePlus
S264WFINTsLILFLG-alphaPhosphoSitePlus
S16EAARRsRRIDRPKC_groupphosphoELM
S27HLRSEsQRQRRG-alpha; DUF2951PhosphoSitePlus
Y231VELSGyDLKLYG-alphaPhosphoSitePlus
S27HLRSEsQRQRRPRKCDHPRD
S16EAARRsRRIDRPAK1phosphoELM

Dephosphorylation site
GNAZ_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000248996D151NCOSMICMelanoma21499247
ENSP00000248996N43SCOSMICMelanoma20424519
ENSP00000248996S80LCOSMICMelanoma20424519
ENSP00000248996P98SCOSMICMelanoma20424519

Differential expressed protein
GNAZ_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GNAZ_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
C3AR_HUMANGNAZ_HUMANGPCR -> GproteingpDB
FPR1_HUMANGNAZ_HUMANGPCR -> GproteingpDB
PKN1_HUMANGNAZ_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCD_HUMANGNAZ_HUMANkinase -> substrateHPRD
KPCA_HUMANGNAZ_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04730Long-term depression

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005834heterotrimeric G-protein complexIBAcellular_component
GO:0005783endoplasmic reticulumTAScellular_component
GO:0007188adenylate cyclase-modulating G-protein coupled recIEAbiological_process
GO:0031821G-protein coupled serotonin receptor bindingIBAmolecular_function
GO:0031683G-protein beta/gamma-subunit complex bindingIBAmolecular_function
GO:0007193adenylate cyclase-inhibiting G-protein coupled recIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0004871signal transducer activityIBAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0031234extrinsic to internal side of plasma membraneIBAcellular_component
GO:0007188adenylate cyclase-modulating G-protein coupled recIBAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0003924GTPase activityIBAmolecular_function
GO:0019001guanyl nucleotide bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0005635nuclear envelopeTAScellular_component
GO:0031821G-protein coupled serotonin receptor bindingIEAmolecular_function
GO:0006184GTP catabolic processIBAbiological_process
GO:0007165signal transductionIEAbiological_process


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