Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF2A_HUMAN
Description:eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [Source:HGNC Symbol;Acc:3265]
Location:chr14 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S49GMILLsELSRRPKR(EIF2AK2RegPhos
Y202VACYGyEGIDAEIF_2_alphaPhosphoSitePlus
S58RRRIRsINKLIS1PhosphoSitePlus
Y235IAPPRyVMTTTEIF_2_alphaPhosphoSitePlus
S52LLSELsRRRIRGCN2RegPhos
S52LLSELsRRRIRPKCdRegPhos
T281KVVTDtDETELPhosphoSitePlus
S52LLSELsRRRIRphosphoELM
T284TDTDEtELARQPhosphoSitePlus
S52LLSELsRRRIREIF2AK1HPRD
S52LLSELsRRRIREIF2AK2HPRD; phosphoELM
S52LLSELsRRRIREIF2AK3HPRD; phosphoELM; RegPhos
T185INRRLtPQAVKEIF_2_alphaPhosphoSitePlus
S52LLSELsRRRIRPRKCDHPRD
S49GMILLsELSRREIF2AK2phosphoELM
S49GMILLsELSRRHPRD; RegPhos
S52LLSELsRRRIRHRIphosphoELM; RegPhos
S58RRRIRsINKLIHPRD
S52LLSELsRRRIRPEKRegPhos
T279EPKVVtDTDETPhosphoSitePlus
S52LLSELsRRRIRS1PhosphoSitePlus
Y82DKEKGyIDLSKS1PhosphoSitePlus
Y200IEVACyGYEGIEIF_2_alphaPhosphoSitePlus
S52LLSELsRRRIRO43422(PRKRI repressorRegPhos
S52LLSELsRRRIRPRKRIRHPRD
Y147YKRPGyGAYDAEIF_2_alphaPhosphoSitePlus
S52LLSELsRRRIRPKR(EIF2AK2RegPhos
S26MVNVRsIAEMGS1PhosphoSitePlus
S49GMILLsELSRRHRIphosphoELM; RegPhos
S49GMILLsELSRRS1PhosphoSitePlus
Y150PGYGAyDAFKHEIF_2_alphaPhosphoSitePlus
S52LLSELsRRRIRPKRRegPhos

Dephosphorylation site
IF2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256383M1ICOSMICOvarian Cancer21720365
ENSP00000256383E15QCOSMICHead and Neck Cancer21798893
ENSP00000256383E221GBIOMARTBreast Cancer21930507, 21930502
ENSP00000425299E221GBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000256383Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.06318646787
ENSP00000256383Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.09818646787
ENSP00000256383Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
IF2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANIF2A_HUMANkinase -> substrateHPRD
E2AK4_HUMANIF2A_HUMANkinase -> substrateRegPhos
E2AK3_HUMANIF2A_HUMANkinase -> substrateHPRD; RegPhos
MARK2_HUMANIF2A_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANIF2A_HUMANkinase -> substrateRobert H Newman (2013)
E2AK1_HUMANIF2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
E2AK2_HUMANIF2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BMR1A_HUMANIF2A_HUMANkinase -> substrateRobert H Newman (2013)
TTK_HUMANIF2A_HUMANkinase -> substrateRobert H Newman (2013)
P52K_HUMANIF2A_HUMANkinase -> substrateHPRD
ZAGL2_HUMANIF2A_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection
hsa05160Hepatitis C
hsa04141Protein processing in endoplasmic reticulum
hsa05162Measles
hsa03013RNA transport
hsa05164Influenza A

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0043558regulation of translational initiation in responseIEAbiological_process
GO:0005844polysomeTAScellular_component
GO:0005851eukaryotic translation initiation factor 2B compleIDAcellular_component
GO:0006413translational initiationTASbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0006412translationIEAbiological_process
GO:0003743translation initiation factor activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0006412translationTASbiological_process
GO:0010494cytoplasmic stress granuleIEAcellular_component
GO:0046777protein autophosphorylationIEAbiological_process
GO:0043022ribosome bindingIDAmolecular_function
GO:0005850eukaryotic translation initiation factor 2 complexIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0010467gene expressionTASbiological_process


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