| UniProt/SwissProt ID: | MEP1B_HUMAN |
| Description: | meprin A, beta [Source:HGNC Symbol;Acc:7020] |
| Location: | chr18 q12.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T611 | DLCSKtTCKND | EGF | PhosphoSitePlus |
| S687 | YRERMsSNRPN | PKC_group | phosphoELM; RegPhos |
| S192 | NFNTYsDDISD | Astacin | PhosphoSitePlus |
| T620 | NDGVCtVRDGK | EGF | PhosphoSitePlus |
| S196 | YSDDIsDSLNV | Astacin | PhosphoSitePlus |
| S242 | QRMDFsDSDLL | Astacin | PhosphoSitePlus |
| S687 | YRERMsSNRPN | PKCd | RegPhos |
| S687 | YRERMsSNRPN | PhosphoSitePlus | |
| T612 | LCSKTtCKNDG | EGF | PhosphoSitePlus |
| S244 | MDFSDsDLLKL | Astacin | PhosphoSitePlus |
| S687 | YRERMsSNRPN | PRKCD | HPRD |
| S198 | DDISDsLNVPY | Astacin | PhosphoSitePlus |
| Dephosphorylation site |
| MEP1B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000269202 | T223I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000269202 | S560T | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| MEP1B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MEP1B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | MEP1B_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04974 | Protein digestion and absorption |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0007586 | digestion | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0008237 | metallopeptidase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0004222 | metalloendopeptidase activity | IEA | molecular_function |