Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KAP0_HUMAN
Description:protein kinase, cAMP-dependent, regulatory, type I, alpha [Source:HGNC Symbol;Acc:9388]
Location:chr17 q24.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T75KAGTRtDSREDPhosphoSitePlus; HPRD; SysPTM
Y373RNIQQyNSFVSPhosphoSitePlus
S77GTRTDsREDEIPhosphoSitePlus; HPRD; RegPhos
S83REDEIsPPPPNCDK2HPRD; RegPhos; SysPTM
S101RRGAIsAEVYTHPRD; RegPhos
T209ALIYGtPRAATCDK2HPRD; RegPhos
Y207ELALIyGTPRAcNMP_bindingPhosphoSitePlus
T239ILMGStLRKRKcNMP_bindingPhosphoSitePlus; SysPTM
Y122VIPKDyKTMAAPhosphoSitePlus
T239ILMGStLRKRKHPRD; SysPTM
T73LQKAGtRTDSRPhosphoSitePlus; HPRD; SysPTM
S375IQQYNsFVSLSPhosphoSitePlus
S83REDEIsPPPPNPhosphoSitePlus; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
KAP0_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376474D229fs*12COSMICNeoplasms by Histologic Type16001434
ENSP00000351410K346TCOSMICHead and Neck Cancer21798893
ENSP00000376474Q275KCOSMICLung Cancer20668451
ENSP00000376474Q167*COSMICThyroid Carcinoma12203783
ENSP00000351410D229fs*12COSMICNeoplasms by Histologic Type16001434
ENSP00000351410Q167*COSMICThyroid Carcinoma12203783
ENSP00000376474S77*COSMICLung Cancer20668451
ENSP00000376475A213DCOSMICNeoplasms by Histologic Type16001434
ENSP00000445625K222ECOSMICAdrenal Gland Neoplasms14500362
ENSP00000351410Q275KCOSMICLung Cancer20668451
ENSP00000376474K222ECOSMICAdrenal Gland Neoplasms14500362
ENSP00000351410K222ECOSMICAdrenal Gland Neoplasms14500362
ENSP00000376474K346TCOSMICHead and Neck Cancer21798893
ENSP00000376475D229fs*12COSMICNeoplasms by Histologic Type16001434
ENSP00000376475S77*COSMICLung Cancer20668451
ENSP00000376475K346TCOSMICHead and Neck Cancer21798893
ENSP00000445625Q167*COSMICThyroid Carcinoma12203783
ENSP00000376474A213DCOSMICNeoplasms by Histologic Type16001434
ENSP00000445625A213DCOSMICNeoplasms by Histologic Type16001434
ENSP00000376475K222ECOSMICAdrenal Gland Neoplasms14500362
ENSP00000445625S77*COSMICLung Cancer20668451
ENSP00000376475Q167*COSMICThyroid Carcinoma12203783
ENSP00000351410S77*COSMICLung Cancer20668451
ENSP00000445625D229fs*12COSMICNeoplasms by Histologic Type16001434
ENSP00000445625Q275KCOSMICLung Cancer20668451
ENSP00000445625K346TCOSMICHead and Neck Cancer21798893
ENSP00000376475Q275KCOSMICLung Cancer20668451
ENSP00000351410A213DCOSMICNeoplasms by Histologic Type16001434

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376474hepatitis C virusNormal vs. CancertissueUp3.418715028
ENSP00000376474Prostate CancerMetastasiscell lineDown0.2115102926

Hyperphosphorylation site
KAP0_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WEE1_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
CDK2_HUMANKAP0_HUMANkinase -> substrateRegPhos
KPCD_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KAP0_HUMAN1A80_HUMANkinase -> substrateHPRD
MK01_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
PRKX_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKAP0_HUMANkinase -> substrateRegPhos
KKCC2_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04210Apoptosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0030552cAMP bindingIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0006833water transportTASbiological_process
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005952cAMP-dependent protein kinase complexIEAcellular_component
GO:0043234protein complexIDAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0031625ubiquitin protein ligase bindingIDAmolecular_function
GO:0050796regulation of insulin secretionTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0008603cAMP-dependent protein kinase regulator activityIEAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process


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