| UniProt/SwissProt ID: | ARI3A_HUMAN |
| Description: | AT rich interactive domain 3A (BRIGHT-like) [Source:HGNC Symbol;Acc:3031] |
| Location: | chr19 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y361 | GSLFAySPGGA | PhosphoSitePlus | |
| S362 | SLFAYsPGGAH | PhosphoSitePlus | |
| S309 | PTSITsAAFTL | ARID | PhosphoSitePlus |
| S81 | ASPGGsEDGPP | PhosphoSitePlus; HPRD; phosphoELM | |
| S584 | GLSTPsTSTSN | PhosphoSitePlus | |
| S77 | LGHPAsPGGSE | PhosphoSitePlus; HPRD; phosphoELM | |
| T98 | AAREGtPGSPG | PhosphoSitePlus | |
| T408 | SAIPItVPGRL | PhosphoSitePlus | |
| S353 | EGRRQsFGGSL | PhosphoSitePlus | |
| S88 | DGPPGsEEEDA | PhosphoSitePlus; HPRD; phosphoELM | |
| T568 | GRGGNtGTSGG | PhosphoSitePlus | |
| S591 | STSNNsLP___ | PhosphoSitePlus | |
| Y276 | DLFMLyVLVTE | ARID | PhosphoSitePlus |
| S119 | FEDMAsDEDMK | PhosphoSitePlus; HPRD | |
| T582 | PAGLStPSTST | PhosphoSitePlus | |
| S101 | EGTPGsPGRGR | PhosphoSitePlus; HPRD | |
| S492 | AQLPMsIRINS | PhosphoSitePlus | |
| Dephosphorylation site |
| ARI3A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263620 | Y530D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263620 | S357F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263620 | Y530D | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000263620 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 9.8 | 18646787 | ENSP00000263620 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.3 | 18646787 |
| Hyperphosphorylation site |
| ARI3A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A4_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AAPK2_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK3_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR4_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ARI3A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0045121 | membrane raft | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | NAS | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |