Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITA6_HUMAN
Description:integrin, alpha 6 [Source:HGNC Symbol;Acc:6142]
Location:chr2 q31.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T716IALEItVTNSPPhosphoSitePlus
T889NLGTAtLNIQWPhosphoSitePlus
S722VTNSPsNPRNPPhosphoSitePlus
Y470KGISPyFGYSIPhosphoSitePlus
T588SEPKYtQELTLPhosphoSitePlus
T887LTNLGtATLNIPhosphoSitePlus
S1043VTVFPsKTVAQPhosphoSitePlus
T932NSLNLtESHNSPhosphoSitePlus
T1045VFPSKtVAQYSPhosphoSitePlus
T825NLAPItAKAKVPhosphoSitePlus
S13CLLYLsAGLLSPhosphoSitePlus
T592YTQELtLKRQKPhosphoSitePlus
Y1129NRNESyS____PhosphoSitePlus
S632IQEPSsRRRVNPhosphoSitePlus
T460LSDSVtIFRSRHPRD
S446DLDRNsYPDVAHPRD
T560ISIVGtLEAEKPhosphoSitePlus
S899WPKEIsNGKWLPhosphoSitePlus
S624IPITAsVEIQEPhosphoSitePlus
S317EITFVsGAPRAPhosphoSitePlus
S648LPILNsDEPKTPhosphoSitePlus
T89YSCDItARGPCPhosphoSitePlus
S85TGGLYsCDITAPhosphoSitePlus
Y449GKVFIyHGSANFG-GAPPhosphoSitePlus
S934LNLTEsHNSRKPhosphoSitePlus
Y473SPYFGySIAGNFG-GAPPhosphoSitePlus
T512INIQKtITVTPPhosphoSitePlus
S187HEKFGsCQQGVPhosphoSitePlus
S1064IHAQPsDKERLHPRD
S937TESHNsRKKREPhosphoSitePlus
Y1110IKDEKyIDNLEPhosphoSitePlus; SysPTM

Dephosphorylation site
ITA6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264107Q485KTCGAOvarian Cancer21720365, 18772890
ENSP00000264107K472*COSMICLung Cancer
ENSP00000386614A261VBIOMARTBreast Cancer21930507, 21930502
ENSP00000264107A380VBIOMARTBreast Cancer21930507, 21930502
ENSP00000264107Q485KCOSMICOvarian Cancer21720365
ENSP00000364369A419VBIOMARTBreast Cancer21930507, 21930502
ENSP00000341078A375VBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000341078Gastric CancerMetastasiscell lineUp3.317022644
ENSP00000341078Oral CancerNormal vs. CancertissueUp2.719297561
ENSP00000341078Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000341078Gastric CancerMetastasiscell lineUp3.317022644
ENSP00000341078Breast CancerMetastasiscell lineDown0.4218729497
ENSP00000341078Breast CancerMetastasiscell lineUp2.0-5.319321434
ENSP00000341078Breast CancerNormal vs. Cancercell lineUp1.620543960
ENSP00000341078Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000341078Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp3.719800108
ENSP00000341078Gastric CancerNormal vs. Cancercell lineUp3.420812763
ENSP00000341078Gastric CancerNormal vs. Cancercell lineUp5.320812763

Hyperphosphorylation site
ITA6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANITA6_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa05145Toxoplasmosis
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
hsa05222Small cell lung cancer
hsa05414Dilated cardiomyopathy
hsa04640Hematopoietic cell lineage
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05410Hypertrophic cardiomyopathy (HCM)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneIDAcellular_component
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0007044cell-substrate junction assemblyTASbiological_process
GO:0031668cellular response to extracellular stimulusIEAbiological_process
GO:0043065positive regulation of apoptotic processIGIbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0005604basement membraneIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042327positive regulation of phosphorylationIMPbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0050900leukocyte migrationIEAbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0009925basal plasma membraneIEAcellular_component
GO:0033627cell adhesion mediated by integrinIEAbiological_process
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0008305integrin complexIEAcellular_component
GO:0030056hemidesmosomeIEAcellular_component
GO:0050900leukocyte migrationTASbiological_process
GO:0022409positive regulation of cell-cell adhesionIEAbiological_process
GO:0031581hemidesmosome assemblyTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0046847filopodium assemblyIEAbiological_process
GO:0050873brown fat cell differentiationIEAbiological_process


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