| UniProt/SwissProt ID: | ITA6_HUMAN |
| Description: | integrin, alpha 6 [Source:HGNC Symbol;Acc:6142] |
| Location: | chr2 q31.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T716 | IALEItVTNSP | PhosphoSitePlus | |
| T889 | NLGTAtLNIQW | PhosphoSitePlus | |
| S722 | VTNSPsNPRNP | PhosphoSitePlus | |
| Y470 | KGISPyFGYSI | PhosphoSitePlus | |
| T588 | SEPKYtQELTL | PhosphoSitePlus | |
| T887 | LTNLGtATLNI | PhosphoSitePlus | |
| S1043 | VTVFPsKTVAQ | PhosphoSitePlus | |
| T932 | NSLNLtESHNS | PhosphoSitePlus | |
| T1045 | VFPSKtVAQYS | PhosphoSitePlus | |
| T825 | NLAPItAKAKV | PhosphoSitePlus | |
| S13 | CLLYLsAGLLS | PhosphoSitePlus | |
| T592 | YTQELtLKRQK | PhosphoSitePlus | |
| Y1129 | NRNESyS____ | PhosphoSitePlus | |
| S632 | IQEPSsRRRVN | PhosphoSitePlus | |
| T460 | LSDSVtIFRSR | HPRD | |
| S446 | DLDRNsYPDVA | HPRD | |
| T560 | ISIVGtLEAEK | PhosphoSitePlus | |
| S899 | WPKEIsNGKWL | PhosphoSitePlus | |
| S624 | IPITAsVEIQE | PhosphoSitePlus | |
| S317 | EITFVsGAPRA | PhosphoSitePlus | |
| S648 | LPILNsDEPKT | PhosphoSitePlus | |
| T89 | YSCDItARGPC | PhosphoSitePlus | |
| S85 | TGGLYsCDITA | PhosphoSitePlus | |
| Y449 | GKVFIyHGSAN | FG-GAP | PhosphoSitePlus |
| S934 | LNLTEsHNSRK | PhosphoSitePlus | |
| Y473 | SPYFGySIAGN | FG-GAP | PhosphoSitePlus |
| T512 | INIQKtITVTP | PhosphoSitePlus | |
| S187 | HEKFGsCQQGV | PhosphoSitePlus | |
| S1064 | IHAQPsDKERL | HPRD | |
| S937 | TESHNsRKKRE | PhosphoSitePlus | |
| Y1110 | IKDEKyIDNLE | PhosphoSitePlus; SysPTM | |
| Dephosphorylation site |
| ITA6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264107 | Q485K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000264107 | K472* | COSMIC | Lung Cancer | ENSP00000386614 | A261V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264107 | A380V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264107 | Q485K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000364369 | A419V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000341078 | A375V | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000341078 | Gastric Cancer | Metastasis | cell line | Up | 3.3 | 17022644 | ENSP00000341078 | Oral Cancer | Normal vs. Cancer | tissue | Up | 2.7 | 19297561 | ENSP00000341078 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | ENSP00000341078 | Gastric Cancer | Metastasis | cell line | Up | 3.3 | 17022644 | ENSP00000341078 | Breast Cancer | Metastasis | cell line | Down | 0.42 | 18729497 | ENSP00000341078 | Breast Cancer | Metastasis | cell line | Up | 2.0-5.3 | 19321434 | ENSP00000341078 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.6 | 20543960 | ENSP00000341078 | Breast Cancer | Cancer vs. Cancer (Non-TNBC vs. TNBC) | cell line | Up | 20596302 | ENSP00000341078 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 3.7 | 19800108 | ENSP00000341078 | Gastric Cancer | Normal vs. Cancer | cell line | Up | 3.4 | 20812763 | ENSP00000341078 | Gastric Cancer | Normal vs. Cancer | cell line | Up | 5.3 | 20812763 |
| Hyperphosphorylation site |
| ITA6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | ITA6_HUMAN | kinase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04510 | Focal adhesion |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (A |
| hsa05145 | Toxoplasmosis |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04512 | ECM-receptor interaction |
| hsa05222 | Small cell lung cancer |
| hsa05414 | Dilated cardiomyopathy |
| hsa04640 | Hematopoietic cell lineage |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05200 | Pathways in cancer |
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0007160 | cell-matrix adhesion | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005178 | integrin binding | IEA | molecular_function |
| GO:0007044 | cell-substrate junction assembly | TAS | biological_process |
| GO:0031668 | cellular response to extracellular stimulus | IEA | biological_process |
| GO:0043065 | positive regulation of apoptotic process | IGI | biological_process |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0042475 | odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042327 | positive regulation of phosphorylation | IMP | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IMP | biological_process |
| GO:0050900 | leukocyte migration | IEA | biological_process |
| GO:0034329 | cell junction assembly | TAS | biological_process |
| GO:0009925 | basal plasma membrane | IEA | cellular_component |
| GO:0033627 | cell adhesion mediated by integrin | IEA | biological_process |
| GO:0007229 | integrin-mediated signaling pathway | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0008305 | integrin complex | IEA | cellular_component |
| GO:0030056 | hemidesmosome | IEA | cellular_component |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0022409 | positive regulation of cell-cell adhesion | IEA | biological_process |
| GO:0031581 | hemidesmosome assembly | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0046847 | filopodium assembly | IEA | biological_process |
| GO:0050873 | brown fat cell differentiation | IEA | biological_process |