Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADRB2_HUMAN
Description:adrenoceptor beta 2, surface [Source:HGNC Symbol;Acc:286]
Location:chr5 q32
Node attribute:substrate; GPCR; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S345LCLRRsSLKAYPhosphoSitePlus; phosphoELM
S411CSTNDsLLGPRK5(GRK5RegPhos
S346CLRRSsLKAYGPhosphoSitePlus; phosphoELM
S355YGNGYsSNGNTGRK_groupphosphoELM; RegPhos
Y219IMVFVySRVFQTM; 7tm_1PhosphoSitePlus
Y350SSLKAyGNGYSINSRHPRD; RegPhos
S262GLRRSsKFCLKPKA_groupphosphoELM; RegPhos
S401SDNIDsQGRNCPhosphoSitePlus
T393VGHQGtVPSDNGRK5HPRD
S396QGTVPsDNIDSBARK1(GRK2RegPhos
Y132IAVDRyFAITSIGF1RphosphoELM; RegPhos
S407QGRNCsTNDSLGPRK5(GRK5RegPhos
S261HGLRRsSKFCLPRKCDHPRD
S262GLRRSsKFCLKPKA_group RegPhos
Y354AYGNGySSNGNINSRHPRD; RegPhos
S401SDNIDsQGRNCGPRK5(GRK5RegPhos
S396QGTVPsDNIDSGRK5HPRD
S407QGRNCsTNDSGRK-5phosphoELM
Y326FNPLIyCRSPDHPRD; phosphoELM; RegPhos
S261HGLRRsSKFCLPKCdRegPhos
T393VGHQGtVPSDNGRK-5phosphoELM
S346CLRRSsLKAYGPRKCDHPRD
Y141TSPFKyQSLLTINSRHPRD; RegPhos
S262GLRRSsKFCLKPKCdRegPhos
T384EDLPGtEDFVGPhosphoSitePlus
S261HGLRRsSKFCLPKA_group RegPhos
S401SDNIDsQGRNCBARK1(GRK2RegPhos
T408GRNCStNDSLLPhosphoSitePlus
S407QGRNCsTNDSLBARK1(GRK2RegPhos
S262GLRRSsKFCLK7tm_1PhosphoSitePlus
S355YGNGYsSNGNTBARK_group RegPhos
S345LCLRRsSLKAYPKA_groupphosphoELM; RegPhos
S345LCLRRsSLKAYPKCdRegPhos
Y141TSPFKyQSLLTIGF1RphosphoELM; RegPhos
Y354AYGNGySSNGNPhosphoSitePlus
S346CLRRSsLKAYGAKT_groupRegPhos
S364NTGEQsGYHVEPhosphoSitePlus; HPRD; RegPhos
S411CSTNDsGRK5HPRD
T393VGHQGtVPSDNGPRK5(GRK5RegPhos
Y132IAVDRyFAITSINSRHPRD; RegPhos
S396QGTVPsDNIDSPhosphoSitePlus
S355YGNGYsSNGNTPhosphoSitePlus
S246HVQNLsQVEQD7tm_1PhosphoSitePlus
S407QGRNCsTNDSGRK-2phosphoELM
S396QGTVPsDNIDSGRK-2phosphoELM
S396QGTVPsDNIDSGRK-5phosphoELM
T68RLQTVtNYFIT7tm_1PhosphoSitePlus
S411CSTNDsLLGPRK5RegPhos
S396QGTVPsDNIDSGPRK5(GRK5RegPhos
S401SDNIDsQGRNCGRK-2phosphoELM
S401SDNIDsQGRNCGRK-5phosphoELM
S356GNGYSsNGNTGBARK_group RegPhos
S345LCLRRsSLKAYPRKCDHPRD
T384EDLPGtEDFVGGRK-5phosphoELM
T384EDLPGtEDFVGGRK-2phosphoELM
T360SSNGNtGEQSGPhosphoSitePlus
S411CSTNDsLL___PhosphoSitePlus
S261HGLRRsSKFCL7tm_1PhosphoSitePlus
S407QGRNCsTNDSLPhosphoSitePlus
S246HVQNLsQVEQDHPRD; phosphoELM; RegPhos
T393VGHQGtVPSDNGPRK5RegPhos
T393VGHQGtVPSDNPhosphoSitePlus
S411CSTNDsGRK-5phosphoELM
Y132IAVDRyFAITS7tm_1PhosphoSitePlus
Y350SSLKAyGNGYSPhosphoSitePlus
S407QGRNCsTNDSGRK5HPRD
T384EDLPGtEDFVGGPRK5RegPhos
S262GLRRSsKFCLKPRKCDHPRD
T384EDLPGtEDFVGGRK5HPRD
S401SDNIDsQGRNCGRK5HPRD
S401SDNIDsQGRNCGPRK5RegPhos
S356GNGYSsNGNTGPhosphoSitePlus
Y326FNPLIyCRSPDTM; 7tm_1PhosphoSitePlus
S407QGRNCsTNDSLGPRK5RegPhos
S346CLRRSsLKAYGPKCdRegPhos
S346CLRRSsLKAYGPKB_groupphosphoELM
T384EDLPGtEDFVGGPRK5(GRK5RegPhos
S356GNGYSsNGNTGGRK_groupphosphoELM; RegPhos
S396QGTVPsDNIDSGPRK5RegPhos
Y141TSPFKyQSLLT7tm_1PhosphoSitePlus
S262GLRRSsKFCLKphosphoELM
S346CLRRSsLKAYGPKA_groupphosphoELM; RegPhos
T384EDLPGtEDFVGBARK1(GRK2RegPhos

Dephosphorylation site
ADRB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305372N352fs>62COSMICOvarian Cancer21720365

Differential expressed protein
ADRB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADRB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DOPO_HUMANADRB2_HUMANligand -> receptorHPMR
ADRB2_HUMANGNAS2_HUMANGPCR -> GproteingpDB
ADRB2_HUMANGNAS1_HUMANGPCR -> GproteingpDB
INSR_HUMANADRB2_HUMANkinase -> substrateRegPhos
ARBK1_HUMANADRB2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GRK5_HUMANADRB2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCD_HUMANADRB2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANADRB2_HUMANkinase -> substrateRegPhos
IGF1R_HUMANADRB2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CREB1_HUMANADRB2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04970Salivary secretion
hsa04020Calcium signaling pathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0045453bone resorptionIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005887integral to plasma membraneIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0045986negative regulation of smooth muscle contractionIEAbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0008333endosome to lysosome transportTASbiological_process
GO:0008179adenylate cyclase bindingIEAmolecular_function
GO:0002032desensitization of G-protein coupled receptor protIDAbiological_process
GO:0031398positive regulation of protein ubiquitinationIMPbiological_process
GO:0001993regulation of systemic arterial blood pressure by IEAbiological_process
GO:0007190activation of adenylate cyclase activityIDAbiological_process
GO:0043235receptor complexIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0030501positive regulation of bone mineralizationIEAbiological_process
GO:0050873brown fat cell differentiationIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0015459potassium channel regulator activityIDAmolecular_function
GO:0006898receptor-mediated endocytosisIDAbiological_process
GO:0005768endosomeTAScellular_component
GO:0002025vasodilation by norepinephrine-epinephrine involveIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0002024diet induced thermogenesisIEAbiological_process
GO:0007171activation of transmembrane receptor protein tyrosTASbiological_process
GO:0004941beta2-adrenergic receptor activityIEAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0004941beta2-adrenergic receptor activityIDAmolecular_function
GO:0031649heat generationIEAbiological_process
GO:0051380norepinephrine bindingIDAmolecular_function
GO:0007189adenylate cyclase-activating G-protein coupled recIEAbiological_process
GO:0005764lysosomeTAScellular_component
GO:0040015negative regulation of multicellular organism growIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0009409response to coldIEAbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process


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