| UniProt/SwissProt ID: | GNAI2_HUMAN |
| Description: | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [Source:HGNC Symbol;Acc:4385] |
| Location: | chrHG325_PATCH p21.3 |
| Node attribute: | Gprotein |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y155 | NDSAAyYLNDL | G-alpha | PhosphoSitePlus |
| S44 | LGAGEsGKSTI | G-alpha | PhosphoSitePlus |
| Y69 | EECRQyRAVVY | HPRD; phosphoELM | |
| Y69 | EECRQyRAVVY | G-alpha | PhosphoSitePlus |
| Y168 | IAQSDyIPTQQ | G-alpha | PhosphoSitePlus |
| Y61 | IHEDGySEEEC | G-alpha | PhosphoSitePlus |
| S144 | ACFGRsREYQL | G-alpha | PhosphoSitePlus |
| S302 | YDEAAsYIQSK | G-alpha | PhosphoSitePlus |
| Y321 | DTKEIyTHFTC | G-alpha | PhosphoSitePlus |
| Dephosphorylation site |
| GNAI2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000312999 | A114T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000312999 | L39F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000312999 | R179H | OMIM | Adrenal Gland Neoplasms | 21079996 | ENSP00000312999 | R179H | OMIM | Neoplasms by Histologic Type | 21079996 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000312999 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 3.3 | 18715028 | ENSP00000312999 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 5.4 | 16215274 | ENSP00000312999 | Gastric Cancer | Metastasis | cell line | Up | 1.3 | 17022644 | ENSP00000312999 | Gastric Cancer | Metastasis | cell line | Up | 1.3 | 17022644 |
| Hyperphosphorylation site |
| GNAI2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04540 | Gap junction |
| hsa04730 | Long-term depression |
| hsa04530 | Tight junction |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04727 | GABAergic synapse |
| hsa04971 | Gastric acid secretion |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa05133 | Pertussis |
| hsa05145 | Toxoplasmosis |
| hsa05034 | Alcoholism |
| hsa04726 | Serotonergic synapse |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04725 | Cholinergic synapse |
| hsa04728 | Dopaminergic synapse |
| hsa04360 | Axon guidance |
| hsa05030 | Cocaine addiction |
| hsa04062 | Chemokine signaling pathway |
| hsa04916 | Melanogenesis |
| hsa05032 | Morphine addiction |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04724 | Glutamatergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0045121 | membrane raft | IEA | cellular_component |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | biological_process |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | TAS | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0001664 | G-protein coupled receptor binding | IBA | molecular_function |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0000186 | activation of MAPKK activity | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0031234 | extrinsic to internal side of plasma membrane | IBA | cellular_component |
| GO:0007243 | intracellular protein kinase cascade | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | IBA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0030496 | midbody | IDA | cellular_component |
| GO:0019001 | guanyl nucleotide binding | IEA | molecular_function |
| GO:0003924 | GTPase activity | IBA | molecular_function |
| GO:0001973 | adenosine receptor signaling pathway | IEA | biological_process |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0006184 | GTP catabolic process | IBA | biological_process |
| GO:0051924 | regulation of calcium ion transport | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0051301 | cell division | IMP | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0007213 | G-protein coupled acetylcholine receptor signaling | IEA | biological_process |
| GO:0050805 | negative regulation of synaptic transmission | IEA | biological_process |
| GO:0005834 | heterotrimeric G-protein complex | IBA | cellular_component |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0007584 | response to nutrient | TAS | biological_process |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | IEA | biological_process |