Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBA1A_HUMAN
Description:tubulin, alpha 1a [Source:HGNC Symbol;Acc:20766]
Location:chr12 q13.12
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y262TNLVPyPRIHFPhosphoSitePlus
T225ERPTYtNLNRLTubulinPhosphoSitePlus
T292SVAEItNACFETubulin_CPhosphoSitePlus
Y172LEFSIyPAPQVTubulinPhosphoSitePlus
Y451EEGEHPRD
S287YHEQLsVAEITHPRD
Y451EEGEEy_____PhosphoSitePlus
S379AVCMLsNTTAITubulin_CPhosphoSitePlus
T190YNSILtTHTTLTubulinPhosphoSitePlus
S198TTLEHsDCAFMTubulinPhosphoSitePlus
Y319ACCLLyRGDVVTubulin_CPhosphoSitePlus
Y432ALEKDyEEVGVPhosphoSitePlus
T73VDLEPtVIDEVTubulinPhosphoSitePlus
S277YAPVIsAEKAYTubulin_CPhosphoSitePlus
T109ARGHYtIGKEITubulinPhosphoSitePlus
Y210DNEAIyDICRRTubulinPhosphoSitePlus
S237GQIVSsITASLPhosphoSitePlus
Y408AFVHWyVGEGMPhosphoSitePlus
T80IDEVRtGTYRQTubulinPhosphoSitePlus
T193ILTTHtTLEHSTubulinPhosphoSitePlus
Y83VRTGTyRQLFHTubulinPhosphoSitePlus
T271HFPLAtYAPVITubulin_CPhosphoSitePlus
S187VEPYNsILTTHTubulinPhosphoSitePlus
T51DDSFNtFFSETHPRD
Y272FPLATyAPVISTubulin_CPhosphoSitePlus
T349VDWCPtGFKVGTubulin_CPhosphoSitePlus
T223DIERPtYTNLNTubulinPhosphoSitePlus
Y282SAEKAyHEQLSTubulin_CPhosphoSitePlus
S48GGGDDsFNTFFHPRD
Y312PRHGKyMACCLTubulin_CPhosphoSitePlus
S158LMERLsVDYGKTubulinPhosphoSitePlus
T337IATIKtKRTIQTubulin_CPhosphoSitePlus
T41MPSDKtIGGGDTubulinPhosphoSitePlus
T361NYQPPtVVPGGTubulin_CPhosphoSitePlus
Y103DAANNyARGHYTubulinPhosphoSitePlus
T94PEQLItGKEDATubulinPhosphoSitePlus
S236IGQIVsSITASPhosphoSitePlus
Y357KVGINyQPPTVTubulin_CPhosphoSitePlus
S48GGGDDsFNTFFTubulinPhosphoSitePlus
T334NAAIAtIKTKRTubulin_CPhosphoSitePlus
T82EVRTGtYRQLFTubulinPhosphoSitePlus
T56TFFSEtGAGKHTubulinPhosphoSitePlus
S54FNTFFsETGAGTubulinPhosphoSitePlus
S287YHEQLsVAEITTubulin_CPhosphoSitePlus
Y399KFDLMyAKRAFPhosphoSitePlus
Y161RLSVDyGKKSKTubulinPhosphoSitePlus
T51DDSFNtFFSETTubulinPhosphoSitePlus
S439EVGVDsVEGEGPhosphoSitePlus; HPRD; SysPTM
T191NSILTtHTTLETubulinPhosphoSitePlus
S151GSGFTsLLMERTubulinPhosphoSitePlus
Y108YARGHyTIGKETubulinPhosphoSitePlus
Y24ACWELyCLEHGTubulinPhosphoSitePlus
Y224IERPTyTNLNRTubulinPhosphoSitePlus
T194LTTHTtLEHSDTubulinPhosphoSitePlus
Y185AVVEPyNSILTTubulinPhosphoSitePlus

Dephosphorylation site
TBA1A_HUMAN do not have dephosphorylation site.

Mutation site
TBA1A_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000301071Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.418646787
ENSP00000301071Hepatocellular CarcinomaNormal vs. Cancercell lineUp3.518646787
ENSP00000301071Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp2.720804217
ENSP00000301071Gastric CancerNormal vs. CancertissueDown0.3419330469
ENSP00000301071Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
TBA1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS2_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GNAI2_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG5_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG3_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBB1_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG11_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GNAS1_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBB3_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG10_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG2_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG13_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBB5_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GNAQ_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG8_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GNAI1_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG1_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GNAI3_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBG12_HUMANTBA1A_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003924GTPase activityIEAmolecular_function
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0051301cell divisionTASbiological_process
GO:0007018microtubule-based movementIEAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005881cytoplasmic microtubuleIEAcellular_component
GO:0006457protein foldingTASbiological_process
GO:0030705cytoskeleton-dependent intracellular transportTASbiological_process
GO:0007017microtubule-based processTASbiological_process
GO:0051258protein polymerizationIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0005874microtubuleTAScellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0044267cellular protein metabolic processTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005200structural constituent of cytoskeletonIEAmolecular_function