Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAR1_HUMAN
Description:coagulation factor II (thrombin) receptor [Source:HGNC Symbol;Acc:3537]
Location:chr5 q13.3
Node attribute:PPI(target); GPCR; receptor; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S396SSDPSsYNSSGHPRD; phosphoELM
S399PSSYNsSGQLMPhosphoSitePlus; HPRD; phosphoELM
S391LCCKEsSDPSSPhosphoSitePlus; HPRD; phosphoELM
S395ESSDPsSYNSSHPRD; phosphoELM
S400SSYNSsGQLMAPhosphoSitePlus; HPRD; phosphoELM
S384QRYVYsILCCKHPRD; phosphoELM
S418SNLNNsIYKKLPhosphoSitePlus; HPRD; phosphoELM
Y420LNNSIyKKLLTPhosphoSitePlus
S392CCKESsDPSSYPhosphoSitePlus; HPRD; phosphoELM
T425YKKLHPRD; phosphoELM
S413MDTCSsNLNNSHPRD; phosphoELM
Y383CQRYVySILCCPhosphoSitePlus; phosphoELM
S376YYYASsECQRYHPRD; phosphoELM
S375IYYYAsSECQRHPRD; phosphoELM
S406GQLMAsKMDTCPhosphoSitePlus; HPRD; phosphoELM
S412KMDTCsSNLNNPhosphoSitePlus; HPRD; phosphoELM
T410ASKMDtCSSNLHPRD; phosphoELM
Y397SDPSSyNSSGQPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
PAR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000321326S376FCOSMICOvarian Cancer21720365
ENSP00000321326H255YCOSMICOvarian Cancer21720365
ENSP00000321326H255YTCGAOvarian Cancer21720365, 18772890
ENSP00000321326S376FTCGAOvarian Cancer21720365, 18772890
ENSP00000321326L249FBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
PAR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PAR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
THRB_HUMANPAR1_HUMANligand -> receptorHPMR
PAR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNA13_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNAI2_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNA12_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNAQ_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNAI1_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNAI3_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNA11_HUMANGPCR -> GproteingpDB
CATG_HUMANPAR1_HUMANotherKEGG
PAR1_HUMANGNA13_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04144Endocytosis
hsa04610Complement and coagulation cascades
hsa04810Regulation of actin cytoskeleton
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007529establishment of synaptic specificity at neuromuscISSbiological_process
GO:0032496response to lipopolysaccharideISSbiological_process
GO:0031681G-protein beta-subunit bindingIEAmolecular_function
GO:0035025positive regulation of Rho protein signal transducIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0031681G-protein beta-subunit bindingISSmolecular_function
GO:0005794Golgi apparatusTAScellular_component
GO:0045907positive regulation of vasoconstrictionIEAbiological_process
GO:0051209release of sequestered calcium ion into cytosolISSbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0004930G-protein coupled receptor activityISSmolecular_function
GO:0005102receptor bindingIPImolecular_function
GO:0003105negative regulation of glomerular filtrationISSbiological_process
GO:0045987positive regulation of smooth muscle contractionISSbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0045211postsynaptic membraneISScellular_component
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0007262STAT protein import into nucleusIDAbiological_process
GO:0031094platelet dense tubular networkIDAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0030194positive regulation of blood coagulationIEAbiological_process
GO:0051281positive regulation of release of sequestered calcIDAbiological_process
GO:1900134negative regulation of renin secretion into blood ISSbiological_process
GO:1900134negative regulation of renin secretion into blood IEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0005901caveolaIDAcellular_component
GO:0000186activation of MAPKK activityISSbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0030194positive regulation of blood coagulationIDAbiological_process
GO:0070493thrombin receptor signaling pathwayIEAbiological_process
GO:0030193regulation of blood coagulationIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0016265deathIEAbiological_process
GO:0045907positive regulation of vasoconstrictionISSbiological_process
GO:0001965G-protein alpha-subunit bindingISSmolecular_function
GO:0032651regulation of interleukin-1 beta productionIEAbiological_process
GO:0035025positive regulation of Rho protein signal transducISSbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationISSbiological_process
GO:0046427positive regulation of JAK-STAT cascadeIDAbiological_process
GO:0043280positive regulation of cysteine-type endopeptidaseIDAbiological_process
GO:2000778positive regulation of interleukin-6 secretionIDAbiological_process
GO:0015057thrombin receptor activityIDAmolecular_function
GO:0048873homeostasis of number of cells within a tissueIEAbiological_process
GO:0002248connective tissue replacement involved in inflammaIDAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0032651regulation of interleukin-1 beta productionISSbiological_process
GO:0043524negative regulation of neuron apoptotic processISSbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIDAbiological_process
GO:0030168platelet activationIDAbiological_process
GO:0032967positive regulation of collagen biosynthetic proceIDAbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0051928positive regulation of calcium ion transportISSbiological_process
GO:0060155platelet dense granule organizationICbiological_process
GO:0048873homeostasis of number of cells within a tissueISSbiological_process
GO:0051930regulation of sensory perception of painISSbiological_process
GO:0006954inflammatory responseISSbiological_process
GO:2000484positive regulation of interleukin-8 secretionIDAbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0051482elevation of cytosolic calcium ion concentration iISSbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0007205protein kinase C-activating G-protein coupled receISSbiological_process
GO:0007260tyrosine phosphorylation of STAT proteinIDAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0031594neuromuscular junctionISScellular_component
GO:0009611response to woundingIDAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process