Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CASR_HUMAN
Description:calcium-sensing receptor [Source:HGNC Symbol;Acc:1514]
Location:chr3 q21.1
Node attribute:GPCR; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T906SLGGStGSTPSPhosphoSitePlus
T888VAARAtLRRSNPKC_alphaphosphoELM
T186KSFLRtIPNDEANF_receptorPhosphoSitePlus
S915PSSSIsSKSNSPhosphoSitePlus
T888VAARAtLRRSNPKCgRegPhos
T888VAARAtLRRSNPKCbRegPhos
T888VAARAtLRRSNPKC_groupphosphoELM; RegPhos
T888VAARAtLRRSNPKCaRegPhos
S899VSRKRsSSLGGPhosphoSitePlus
T888VAARAtLRRSNPKCa(PKC alphaRegPhos
S342VHPRKsVHNGFANF_receptorPhosphoSitePlus; SysPTM
T888VAARAtLRRSNPRKCGHPRD
T888VAARAtLRRSNPRKCAHPRD
T888VAARAtLRRSNPRKCBHPRD
T888VAARAtLRRSNPhosphoSitePlus
S892ATLRRsNVSRKPhosphoSitePlus
T195DEHQAtAMADIANF_receptorPhosphoSitePlus
S900SRKRSsSLGGSPhosphoSitePlus
S895RRSNVsRKRSSPhosphoSitePlus

Dephosphorylation site
CASR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296154A2ECOSMICSkin Cancer21984974
ENSP00000296154R1041WCOSMICOvarian Cancer21720365
ENSP00000296154D275NBIOMARTBreast Cancer21930507, 21930502
ENSP00000296154R66HCOSMICOvarian Cancer21720365
ENSP00000296154R678HCOSMICOvarian Cancer21720365
ENSP00000296154E475DTCGAOvarian Cancer21720365, 18772890
ENSP00000418685V424IBIOMARTGastric Cancer21930507, 21930502
ENSP00000296154R678HTCGAOvarian Cancer21720365, 18772890
ENSP00000296154R66HTCGAOvarian Cancer21720365, 18772890
ENSP00000418685E475DTCGAOvarian Cancer21720365, 18772890
ENSP00000296154E475DCOSMICOvarian Cancer21720365
ENSP00000418685D275NBIOMARTBreast Cancer21930507, 21930502
ENSP00000418685R678HTCGAOvarian Cancer21720365, 18772890
ENSP00000418685R66HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
CASR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CASR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CASR_HUMANGNA11_HUMANGPCR -> GproteingpDB
CASR_HUMANGNA12_HUMANGPCR -> GproteingpDB
CASR_HUMANGNA13_HUMANGPCR -> GproteingpDB
CASR_HUMANGNAO_HUMANGPCR -> GproteingpDB
CASR_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CASR_HUMANGNAI2_HUMANGPCR -> GproteingpDB
CASR_HUMANGNAQ_HUMANGPCR -> GproteingpDB
CASR_HUMANGNAI1_HUMANGPCR -> GproteingpDB
KPCG_HUMANCASR_HUMANkinase -> substrateHPRD
KPCB_HUMANCASR_HUMANkinase -> substrateHPRD
KPCA_HUMANCASR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
CASR_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007635chemosensory behaviorTASbiological_process
GO:0006874cellular calcium ion homeostasisTASbiological_process
GO:0001503ossificationTASbiological_process
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0070509calcium ion importIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005513detection of calcium ionTASbiological_process
GO:0004435phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function


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