| UniProt/SwissProt ID: | SSR4_HUMAN |
| Description: | somatostatin receptor 4 [Source:HGNC Symbol;Acc:11333] |
| Location: | chr20 p11.21 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T385 | IPLTRtTTF__ | PhosphoSitePlus | |
| Dephosphorylation site |
| SSR4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000255008 | V295L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000255008 | R319H | COSMIC | Ovarian Cancer | 20668451 |
| Differential expressed protein |
| SSR4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SSR4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SMS_HUMAN | SSR4_HUMAN | ligand -> receptor | HPMR |
| CORT_HUMAN | SSR4_HUMAN | ligand -> receptor | HPMR |
| SSR4_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| SSR4_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| SSR4_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| SSR4_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0043410 | positive regulation of MAPK cascade | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016477 | cell migration | IEA | biological_process |
| GO:0038170 | somatostatin signaling pathway | IEA | biological_process |
| GO:0071385 | cellular response to glucocorticoid stimulus | IEA | biological_process |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0030815 | negative regulation of cAMP metabolic process | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0004994 | somatostatin receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0019369 | arachidonic acid metabolic process | IEA | biological_process |