| UniProt/SwissProt ID: | CCR6_HUMAN |
| Description: | chemokine (C-C motif) receptor 6 [Source:HGNC Symbol;Acc:1607] |
| Location: | chr6 q27 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y352 | SCAGRySENIS | PhosphoSitePlus | |
| Dephosphorylation site |
| CCR6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339393 | D10N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000343952 | D10N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000343952 | D10N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000339393 | D10N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000383715 | D10N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000383715 | D10N | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CCR6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CCR6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CCR6_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| CCR6_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| CCR6_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| CCR6_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04062 | Chemokine signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0016493 | C-C chemokine receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0004950 | chemokine receptor activity | TAS | molecular_function |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0002407 | dendritic cell chemotaxis | TAS | biological_process |
| GO:0070098 | chemokine-mediated signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006935 | chemotaxis | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006968 | cellular defense response | TAS | biological_process |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0006959 | humoral immune response | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |